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Magnetoencephalography and electroencephalography (M/EEG) are non-invasive modalities that measure the weak electromagnetic fields generated by neural activity. Estimating the location and magnitude of the current sources that generated…

Machine Learning · Statistics 2019-10-16 Hicham Janati , Thomas Bazeille , Bertrand Thirion , Marco Cuturi , Alexandre Gramfort

In multi-condition EEG experiments, brain activity is recorded as subjects perform various tasks or are exposed to different stimuli. The recorded signals are commonly transformed into time-frequency representations, which often display…

Methodology · Statistics 2025-07-29 Xiaomeng Ju , Thaddeus Tarpey , Hyung G Park

Background: Dementia, marked by cognitive decline, is a global health challenge. Alzheimer's disease (AD), the leading type, accounts for ~70% of cases. Electroencephalography (EEG) measures show promise in identifying AD risk, but…

Signal Processing · Electrical Eng. & Systems 2024-11-28 Veronica Henao Isaza , David Aguillon , Carlos Andres Tobon Quintero , Francisco Lopera , John Fredy Ochoa Gomez

Recently, we reported an emotion self-regulation study (Zotev et al., 2020), in which patients with major depressive disorder (MDD) used simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) to upregulate two fMRI and two EEG…

Neurons and Cognition · Quantitative Biology 2020-10-23 Vadim Zotev , Jerzy Bodurka

Reliable diagnosis of depressive disorder is essential for both optimal treatment and prevention of fatal outcomes. In this study, we aimed to elucidate the effectiveness of two non-linear measures, Higuchi Fractal Dimension (HFD) and…

A methodology for binary classification of EEG records which correspond to different mental states is proposed. This model-free methodology is based on our theory of the $\epsilon$-complexity of continuous functions which is extended here…

Applications · Statistics 2016-10-07 Boris Darkhovsky , Alexandra Piryatinska , Alexander Kaplan

The Early diagnosis and treatment of depression is essential for effective treatment. Depression, while being one of the most common mental illnesses, is still poorly understood in both research and clinical practice. Among different…

Signal Processing · Electrical Eng. & Systems 2023-03-13 Abdolkarim Saeedi , Arash Maghsoudi , Fereidoun Nowshiravan Rahatabad

Depression is a common mental disorder worldwide which causes a range of serious outcomes. The diagnosis of depression relies on patient-reported scales and psychiatrist interview which may lead to subjective bias. In recent years, more and…

Audio and Speech Processing · Electrical Eng. & Systems 2020-03-02 Zhenyu Liu , Dongyu Wang , Lan Zhang , Bin Hu

This work presents a new approach, called MISFIT, for fitting generalized functional linear regression models with sparsely and irregularly sampled data. Current methods do not allow for consistent estimation unless one assumes that the…

Methodology · Statistics 2022-05-10 Justin Petrovich , Matthew Reimherr , Carrie Daymont

This study aims to identify a set of indicators to estimate cognitive workload using a multimodal sensing approach and machine learning. A set of three cognitive tests were conducted to induce cognitive workload in twelve participants at…

Neurons and Cognition · Quantitative Biology 2022-05-10 Niraj Hirachan , Anita Mathews , Julio Romero , Raul Fernandez Rojas

Embedded in any speech signal is a rich combination of cognitive, neuromuscular and physiological information. This richness makes speech a powerful signal in relation to a range of different health conditions, including major depressive…

Sound · Computer Science 2022-04-04 Salvatore Fara , Stefano Goria , Emilia Molimpakis , Nicholas Cummins

As the aging population grows, particularly for the baby boomer generation, the United States is witnessing a significant increase in the elderly population experiencing multifunctional disabilities. These disabilities, stemming from a…

Machine Learning · Computer Science 2024-04-09 Suiyao Chen , Xinyi Liu , Yulei Li , Jing Wu , Handong Yao

For nonparametric inference about a function, multiscale testing procedures resolve the need for bandwidth selection and achieve asymptotically optimal detection performance against a broad range of alternatives. However, critical values…

Statistics Theory · Mathematics 2025-06-06 Johann Köhne , Fabian Mies

Data analysis based on information from several sources is common in economic and biomedical studies. This setting is often referred to as the data fusion problem, which differs from traditional missing data problems since no complete data…

Methodology · Statistics 2022-04-07 Wei Li , Shanshan Luo , Wangli Xu

This study integrates causal inference, graph analysis, temporal complexity measures, and machine learning to examine whether individual symptom trajectories can reveal meaningful diagnostic patterns. Testing on a longitudinal dataset of…

Applications · Statistics 2025-07-22 Eleonora Vitanza , Pietro DeLellis , Chiara Mocenni , Manuel Ruiz Marin

As the number of automatic tools based on machine learning (ML) and resting-state electroencephalography (rs-EEG) for Parkinson's disease (PD) detection keeps growing, the assessment of possible exacerbation of health disparities by means…

Signal Processing · Electrical Eng. & Systems 2023-03-14 Anna Kurbatskaya , Alberto Jaramillo-Jimenez , John Fredy Ochoa-Gomez , Kolbjørn Brønnick , Alvaro Fernandez-Quilez

Parkinsons disease (PD) alters cortical neural dynamics, yet reliable non-invasive electrophysiological biomarkers remain elusive. This study examined whether interpretable EEG features capturing complementary aspects of neural dynamics can…

Neurons and Cognition · Quantitative Biology 2026-04-14 Antonios G. Dougalis

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

Methodology · Statistics 2023-12-04 Anass B. El-Yaagoubi , Hernando Ombao

Depression has been a leading cause of mental-health illnesses across the world. While the loss of lives due to unmanaged depression is a subject of attention, so is the lack of diagnostic tests and subjectivity involved. Using behavioural…

Artificial Intelligence · Computer Science 2020-10-07 Shivani Shimpi , Shyam Thombre , Snehal Reddy , Ritik Sharma , Srijan Singh

Although approaches for handling missing data from longitudinal studies are well-developed when the patterns of missingness are monotone, fewer methods are available for non-monotone missingness. Moreover, the conventional missing at random…

Methodology · Statistics 2023-02-28 Boyu Ren , Stuart R. Lipsitz , Roger D. Weiss , Garrett M. Fitzmaurice