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A source of high-energy photons, ions, and positrons can be attained with the interaction of ultra-intense femtosecond laser pulses with advanced nanostructured targets. We present and characterise a numerical model that mimics the foam…
Using two-dimensional (2D) and three-dimensional (3D) kinetic simulations, we examine the impact of simulation dimensionality on the laser-driven electron acceleration and the emission of collimated $\gamma$-ray beams from hollow…
Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In…
Liquid-argon scintillation detectors are used in fundamental physics experiments and are being considered for security applications. Previous studies have suggested that the addition of small amounts of xenon dopant improves performance in…
Purpose: To describe a concept of a compact electron accelerator for external radiation therapy with variable energy in the range of 6 - 20 MeV, based on linotron principle. Methods: Beam dynamics simulation using the CST and MAD-X code.…
Non-coplanar Intensity-Modulated Radiation Therapy (IMRT) goes a step further by orienting the gantry carrying the radiation beam and the patient couch in a non-coplanar manner to accurately target the cancer region and better avoid…
In this study, two proton beam delivery designs, passive scattering proton therapy (PSPT) and pencil beam scanning (PBS), were quantitatively compared in terms of dosimetric indices. The GATE Monte Carlo code was used to simulate the proton…
Particle therapy is an established method to treat deep-seated tumours using accelerator-produced ion beams. For treatment planning, the precise knowledge of the relative stopping power (RSP) within the patient is vital. Conversion errors…
Plasma-based parametric amplification using stimulated Brillouin scattering offers a route to coherent x-ray pulses orders-of-magnitude more intense than those of the brightest available sources. Brillouin amplification permits…
Purpose: The FLASH effect, which reduces the radiosensitivity of healthy tissue while maintaining tumor control at high dose rates, has shown potential for improving radiation therapy. Conformal FLASH proton therapy involves advanced…
Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription…
To improve the quality of cancer treatment with protons, a translation of X-ray Computed Tomography (CT) images into a map of the proton stopping powers needs to be more accurate. Proton stopping powers determined from CT images have…
Pencil x-ray beam imaging provides superior spatial resolution than other imaging geometries like sheet beam and cone beam geometries due to the illumination of a line instead of an area or volume. However, the pencil beam geometry suffers…
Purpose: To assess the effects of brain movements induced by heartbeat on dose distributions in synchrotron micro- and mini-beam radiaton therapy and to develop a model to help guide decisions and planning for future clinical trials.…
Compared with the start-of-art energy integration detectors (EIDs), photon-counting detectors (PCDs) with energy discrimination capabilities have demonstrated great potentials in various applications of medical x-ray radiography and…
Charge-transfer (CT) exciton effects are investigated for the optical absorption spectra of crosslinked C60 systems by using the intermediate exciton theory. We consider the C60-dimers, and the two (and three) molecule systems of the…
In order to enhance LIDAR performance metrics such as target detection sensitivity, noise resilience and ranging accuracy, we exploit the strong temporal correlation within the photon pairs generated in continuous-wave pumped semiconductor…
We investigated plasma heating enhancement using a high-intensity, high-contrast laser and a cone-attached target. Fast electron spectra and X-ray emission were measured with an electron spectrometer and a Bragg crystal spectrometer. The…
The XCAT phantom is a realistic 4D digital torso phantom that is widely used in imaging and therapy research. However, lung mass is not conserved between respiratory phases of the phantom, making detailed dosimetric simulations and dose…
Radiotherapy using very high-energy electron (VHEE) beams generated by a laser-plasma accelerator has garnered significant interest due to its dose distribution capabilities and potential to address limitations of traditional photon-based…