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This overview article makes the case for how topological concepts can enrich research in machine learning. Using the Euler Characteristic Transform (ECT), a geometrical-topological invariant, as a running example, I present different use…

Machine Learning · Computer Science 2026-01-16 Bastian Rieck

Deep Learning methods, specifically convolutional neural networks (CNNs), have seen a lot of success in the domain of image-based data, where the data offers a clearly structured topology in the regular lattice of pixels. This…

Machine Learning · Statistics 2018-05-31 Thomas Teh , Chaiyawan Auepanwiriyakul , John Alexander Harston , A. Aldo Faisal

We perform topological data analysis on the internal states of convolutional deep neural networks to develop an understanding of the computations that they perform. We apply this understanding to modify the computations so as to (a) speed…

Machine Learning · Computer Science 2018-11-06 Gunnar Carlsson , Rickard Brüel Gabrielsson

Connectomics is an emerging field in neuroscience that aims to reconstruct the 3-dimensional morphology of neurons from electron microscopy (EM) images. Recent studies have successfully demonstrated the use of convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2017-02-27 Shibani Santurkar , David Budden , Alexander Matveev , Heather Berlin , Hayk Saribekyan , Yaron Meirovitch , Nir Shavit

Representation learning on large-scale unstructured volumetric and surface meshes poses significant challenges in neuroimaging, especially when models must incorporate diverse vertex-level morphometric descriptors, such as cortical…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Yujian Xiong , Mohammad Farazi , Yanxi Chen , Wenhui Zhu , Xuanzhao Dong , Natasha Lepore , Yi Su , Raza Mushtaq , Stephen Foldes , Andrew Yang , Yalin Wang

Recent 2D-to-3D human pose estimation works tend to utilize the graph structure formed by the topology of the human skeleton. However, we argue that this skeletal topology is too sparse to reflect the body structure and suffer from serious…

Computer Vision and Pattern Recognition · Computer Science 2023-04-05 Han Li , Bowen Shi , Wenrui Dai , Yabo Chen , Botao Wang , Yu Sun , Min Guo , Chenlin Li , Junni Zou , Hongkai Xiong

In the study of neurons, morphology influences function. The complexity in the structure of neurons poses a challenge in the identification and analysis of similar and dissimilar neuronal cells. Existing methodologies carry out structural…

Image and Video Processing · Electrical Eng. & Systems 2018-02-21 Tamal Batabyal , Scott T. Acton

Many biological and medical tasks require the delineation of 3D curvilinear structures such as blood vessels and neurites from image volumes. This is typically done using neural networks trained by minimizing voxel-wise loss functions that…

Computer Vision and Pattern Recognition · Computer Science 2022-12-27 Doruk Oner , Hussein Osman , Mateusz Kozinski , Pascal Fua

Reconstructing a map of neuronal connectivity is a critical challenge in contemporary neuroscience. Recent advances in high-throughput serial section electron microscopy (EM) have produced massive 3D image volumes of nanoscale brain tissue…

Various structures in human physiology follow a treelike morphology, which often expresses complexity at very fine scales. Examples of such structures are intrathoracic airways, retinal blood vessels, and hepatic blood vessels. Large…

Image and Video Processing · Electrical Eng. & Systems 2022-09-23 Hao Li , Zeyu Tang , Yang Nan , Guang Yang

This paper focuses on the statistical analysis of shapes of data objects called shape graphs, a set of nodes connected by articulated curves with arbitrary shapes. A critical need here is a constrained registration of points (nodes to…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Shenyuan Liang , Mauricio Pamplona Segundo , Sathyanarayanan N. Aakur , Sudeep Sarkar , Anuj Srivastava

High-dimensional neural activity often reside in a low-dimensional subspace, referred to as neural manifolds. Grid cells in the medial entorhinal cortex provide a periodic spatial code that are organized near a toroidal manifold,…

Neurons and Cognition · Quantitative Biology 2025-10-22 Yuxing Jared Yao , Iris H. R. Yoon

We propose an approach for the generation of topology-optimized structures with text-guided appearance stylization. This methodology aims to enrich the concurrent design of a structure's physical functionality and aesthetic appearance.…

Computational Engineering, Finance, and Science · Computer Science 2023-10-25 Shengze Zhong , Parinya Punpongsanon , Daisuke Iwai , Kosuke Sato

Topology optimization is computationally demanding that requires the assembly and solution to a finite element problem for each material distribution hypothesis. As a complementary alternative to the traditional physics-based topology…

Machine Learning · Computer Science 2018-08-23 Saurabh Banga , Harsh Gehani , Sanket Bhilare , Sagar Patel , Levent Kara

Topology is a powerful tool for categorizing magnetization textures by defining a topological index in both two-dimensional (2D) systems, such as thin films or curved surfaces, and in 3D bulk systems. In the emerging field of 3D…

Automatic segmentation of neuronal topology is critical for handling large scale neuroimaging data, as it can greatly accelerate neuron annotation and analysis. However, the intricate morphology of neuronal branches and the occlusions among…

Image and Video Processing · Electrical Eng. & Systems 2025-08-01 Huayu Fu , Jiamin Li , Haozhi Qu , Xiaolin Hu , Zengcai Guo

The connectome, a map of the structural and/or functional connections in the brain, provides a complex representation of the neurobiological phenotypes on which it supervenes. This information-rich data modality has the potential to…

The complexity and non-Euclidean structure of graph data hinder the development of data augmentation methods similar to those in computer vision. In this paper, we propose a feature augmentation method for graph nodes based on topological…

Machine Learning · Computer Science 2021-04-07 Rui Song , Fausto Giunchiglia , Ke Zhao , Hao Xu

This work presents a procedure to extract morphological information from neuronal cells based on the variation of shape functionals as the cell geometry undergoes a dilation through a wide interval of spatial scales. The targeted shapes are…

This paper introduces the geodesics of triangulated image object shapes. Both rectilinear and curvilinear triangulations of shapes are considered. The triangulation of image object shapes leads to collections of what are known as nerve…

Computational Geometry · Computer Science 2017-08-25 M. Z. Ahmad , J. F. Peters
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