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Most existing cross-modal generative methods based on diffusion models use guidance to provide control over the latent space to enable conditional generation across different modalities. Such methods focus on providing guidance through…

Machine Learning · Computer Science 2023-05-31 Zizhao Hu , Mohammad Rostami

This paper focuses on the analysis of sequential image data, particularly brain imaging data such as MRI, fMRI, CT, with the motivation of understanding the brain aging process and neurodegenerative diseases. To achieve this goal, we…

Machine Learning · Statistics 2024-07-22 Zhenghao Li , Sanyou Wu , Long Feng

Positron emission tomography (PET) is a medical imaging method based on the measurement of concentrations of positron-emitting radionuclides in a living body. In the PET imaging system, glucose is labeled with a positron-emitting…

Signal Processing · Electrical Eng. & Systems 2022-09-27 Mehmet Akif Ozdemir , Ali Tangel

Magnetic resonance imaging (MRI) and positron emission tomography (PET) are increasingly used in multimodal analysis of neurodegenerative disorders. While MRI is broadly utilized in clinical settings, PET is less accessible. Many studies…

Image and Video Processing · Electrical Eng. & Systems 2024-11-13 Minhui Yu , Mengqi Wu , Ling Yue , Andrea Bozoki , Mingxia Liu

Sub-visible particle analysis using flow imaging microscopy combined with deep learning has proven effective in identifying particle types, enabling the distinction of harmless components such as silicone oil from protein particles.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Utku Ozbulak , Michaela Cohrs , Hristo L. Svilenov , Joris Vankerschaver , Wesley De Neve

As PET imaging is accompanied by substantial radiation exposure and cancer risk, reducing radiation dose in PET scans is an important topic. Recently, diffusion models have emerged as the new state-of-the-art generative model to generate…

Image and Video Processing · Electrical Eng. & Systems 2023-11-30 Huidong Xie , Weijie Gan , Bo Zhou , Xiongchao Chen , Qiong Liu , Xueqi Guo , Liang Guo , Hongyu An , Ulugbek S. Kamilov , Ge Wang , Chi Liu

Early and accurate detection of Alzheimer's disease (AD) is crucial for enabling timely intervention and improving outcomes. However, developing reliable machine learning (ML) models for AD diagnosis is challenging due to limited labeled…

Machine Learning · Computer Science 2025-11-27 Abolfazl Moslemi , Hossein Peyvandi

Accurate PET imaging increasingly requires methods that support unconstrained detector layouts from walk-through designs to long-axial rings where gaps and open sides lead to severely undersampled sinograms. Instead of constraining the…

Machine Learning · Computer Science 2025-11-13 Rüveyda Yilmaz , Julian Thull , Johannes Stegmaier , Volkmar Schulz

Synthetic PET images are valuable for quantitative imaging workflow development, scalable virtual imaging trials, and deep learning model training, but conventional physics-based simulation approaches are computationally intensive, limited…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Suya Li , Kaushik Dutta , Debojyoti Pal , Jingqin Luo , Kooresh I. Shoghi

Class-conditional image generation using generative adversarial networks (GANs) has been investigated through various techniques; however, it continues to face challenges such as mode collapse, training instability, and low-quality output…

Computer Vision and Pattern Recognition · Computer Science 2023-06-07 Taesun Yeom , Minhyeok Lee

Image reconstruction from computed tomography (CT) measurement is a challenging statistical inverse problem since a high-dimensional conditional distribution needs to be estimated. Based on training data obtained from high-quality…

Image and Video Processing · Electrical Eng. & Systems 2020-06-12 Alexander Denker , Maximilian Schmidt , Johannes Leuschner , Peter Maass , Jens Behrmann

Generating positron emission tomography (PET) images from computed tomography (CT) scans via deep learning offers a promising pathway to reduce radiation exposure and costs associated with PET imaging, improving patient care and…

Image and Video Processing · Electrical Eng. & Systems 2026-02-16 Valerio Guarrasi , Francesco Di Feola , Rebecca Restivo , Lorenzo Tronchin , Paolo Soda

Diagnosing dementia, particularly for Alzheimer's Disease (AD) and frontotemporal dementia (FTD), is complex due to overlapping symptoms. While magnetic resonance imaging (MRI) and positron emission tomography (PET) data are critical for…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Yitong Li , Morteza Ghahremani , Youssef Wally , Christian Wachinger

Positron emission tomography (PET) imaging is widely used in a number of clinical applications, including cancer and Alzheimer's disease (AD) diagnosis, monitoring of disease development, and treatment effect evaluation. Statistical…

Tissues and Organs · Quantitative Biology 2025-11-07 Akhil Ambekar , Robert Zielinski , Ani Eloyan

Deep learning models have emerged as a powerful tool for various medical applications. However, their success depends on large, high-quality datasets that are challenging to obtain due to privacy concerns and costly annotation. Generative…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Milad Yazdani , Yasamin Medghalchi , Pooria Ashrafian , Ilker Hacihaliloglu , Dena Shahriari

PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is time-consuming by PET-MRI systems. We aim to accelerate MRI and improve PET image quality. This paper proposed a novel joint…

Computer Vision and Pattern Recognition · Computer Science 2024-08-23 Taofeng Xie , Zhuoxu Cui , Congcong Liu , Chen Luo , Huayu Wang , Yuanzhi Zhang , Xuemei Wang , Yihang Zhou , Qiyu Jin , Guoqing Chen , Dong Liang , Haifeng Wang

Zero-shot MRI reconstruction relies on generative priors, but single-modality unconditional priors produce hallucinations under severe ill-posedness. In many clinical workflows, complementary MRI acquisitions (e.g. high-quality structural…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Seunghoi Kim , Chen Jin , Henry F. J. Tregidgo , Matteo Figini , Daniel C. Alexander

$Objective$. Obtaining the intrinsic dose distributions in particle therapy is a challenging problem that needs to be addressed by imaging algorithms to take advantage of secondary particle detectors. In this work, we investigate the…

Instrumentation and Detectors · Physics 2022-09-28 Atiq. Ur. Rahman , Mythra Varun. Nemallapudi , Cheng-Ying. Chou , Shih-Chang Lee , Chih-Hsun. Lin

Deep learning is widely applied in computer-aided pathological diagnosis, which alleviates the pathologist workload and provide timely clinical analysis. However, most models generally require large-scale annotated data for training, which…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Zeyu Liu , Tianyi Zhang , Yufang He , Yunlu Feng , Yu Zhao , Guanglei Zhang

Generative models have gained popularity for their potential applications in imaging science, such as image reconstruction, posterior sampling and data sharing. Flow-based generative models are particularly attractive due to their ability…

Machine Learning · Computer Science 2023-12-14 Varun A. Kelkar , Rucha Deshpande , Arindam Banerjee , Mark A. Anastasio