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Accurate, label-free quantification of multiple analytes in complex biological media remains a major challenge due to limited multiplexing, signal cross-correlations, and inconsistency across sensor samples and measurement runs. We…

Whispering gallery mode (WGM) laser sensors, utilizing the interaction between the in-plane evanescent field and the surface vicinity, provide enhanced sensitivity in label-free sensing for bioanalysis and disease screening. However, the…

Optics · Physics 2025-08-25 Xiaolu Cui , Jiyang Ma , Hao Wu , Shuoying Zhao , Xubiao Peng , Chuyu Li , Ruiqi Ming , Qing Zhao

Whispering gallery mode (WGM) microtoroid resonators are one of the most sensitive biochemical sensors in existence, capable of detecting single molecules. The main barrier for translating these devices out of the laboratory is that light…

Optics · Physics 2024-03-18 Sartanee Suebka , Euan McLeod , Judith Su

Optical whispering gallery mode (WGM) microresonators, confining resonant photons in a microscale resonator for long periods of time, could strongly enhance light-matter interaction, making it an ideal platform for all kinds of sensors. In…

Optics · Physics 2021-07-06 Xuefeng Jiang , Abraham J. Qavi , Steven H. Huang , Lan Yang

We develop a compact whispering-gallery-mode (WGM) sensing system by integrating multiple components, including a tunable laser, a temperature controller, a function generator, an oscilloscope, a photodiode detector, and a testing computer,…

Optics · Physics 2016-11-23 Xiangyi Xu , Xuefeng Jiang , Guangming Zhao , Lan Yang

Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive realtime observation of motor molecule motion. However, to date…

Fiber based whispering-gallery-mode (WGM) microprobe, combining both the high optical field enhancement of the WGMs and the practicability of the fiber probe, is highly demanded in sensing and imaging. Here in this paper, we experimentally…

Optics · Physics 2018-08-21 Fangjie Shu , Xuefeng Jiang , Guangming Zhao , Lan Yang

The whispering gallery modes (WGMs) of optical resonators have prompted intensive research efforts due to their usefulness in the field of biological sensing, and their employment in nonlinear optics. While much information is available in…

In this work, we present the design and fabrication of a packaged whispering gallery mode (WGM) device based on an optical nanoantenna as the coupler and a glass microsphere as the resonator. The microspheres were fabricated from SiO$_2$…

Studies of biochemical liquids require precise determination of their complex permittivity. We developed a microwave characterization technique on the basis of a high-quality whispering-gallery mode (WGM) sapphire resonator with a…

Recently optical whispering-gallery-mode resonators (WGMRs) have emerged as promising platforms to achieve label-free detection of nanoscale objects and to reach single molecule sensitivity. The ultimate detection performance of WGMRs are…

A microfluidic whispering gallery mode (WGM) biosensing system is proposed for enhanced delivery and detection of target molecules. A microtoroid resonator coupled to a tapered optical fiber is immersed within a microfluidic channel, and…

Optics · Physics 2018-04-09 Kiran Khosla , Jon D. Swaim , Joachim Knittel , Warwick P. Bowen

In this study, an integrated low-cost and complexity mm-wave structure of Whispering Gallery Mode (WGM) is proposed for sensing the glucose levels in mimicking aquatic solutions of concentrations similar to type 2 diabetics. The bio-sensor…

Applied Physics · Physics 2019-09-30 Ala Eldin Omer , George Shaker , Safieddin Safavi-Naeini

Micro and nanoscale particles are crucial in various fields, from biomedical imaging to environmental processes. While conventional spectroscopy and microscopy methods for characterizing these particles often involve bulky equipment and…

Biological Physics · Physics 2024-11-26 Jie Liao , Maxwell Adolphson , Hangyue Li , Dipayon Kumar Sikder , Chenyang Lu , Lan Yang

Whispering gallery mode (WGM) optical resonators utilizing resonance shift (RS) and mode splitting (MS) techniques have emerged as highly sensitive platforms for label-free detection of nano-scale objects. RS method has been demonstrated in…

Optics · Physics 2015-03-19 Kim Woosung , Sahin Kaya Ozdemir , Jiangang Zhu , Lan Yang

Whispering gallery mode (WGM) optomechanical resonators are a promising technology for the simultaneous control and measurement of optical and mechanical degrees of freedom at the nanoscale. They offer potential for use across a wide range…

Discerning the neurotransmitter dysregulation is a hallmark of neurological disorders and diseases, including Alzheimer's, Parkinson's, and multiple sclerosis. The concentration of neurotransmitters in the synaptic cleft is particularly…

Similar to microspheres, thin-walled microbubble resonators support whispering gallery modes (WGMs) that combine ultrahigh Q-factors and small effective mode volumes. In contrast, their hollow nature enables enhanced interactions with…

Biophotonics - and more recently, biointegrated photonics - offer transformative tools for probing cellular processes with unprecedented precision. Among these, whispering gallery mode (WGM) resonators - optical microcavities formed in…

Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring and molecu-lar biology research, by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on…

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