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Microscopy is the workhorse of the physical and life sciences, producing crisp images of everything from atoms to cells well beyond the capabilities of the human eye. However, the analysis of these images is frequently little better than…

Soft Condensed Matter · Physics 2017-10-18 Matthew Bierbaum , Brian D. Leahy , Alexander A. Alemi , Itai Cohen , James P. Sethna

Inverse problems in image reconstruction are fundamentally complicated by unknown noise properties. Classical iterative deconvolution approaches amplify noise and require careful parameter selection for an optimal trade-off between…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Mikhail Papkov , Kaupo Palo , Leopold Parts

There is a high demand for fully automated methods for the analysis of primary particle size distributions of agglomerates on transmission electron microscopy images. Therefore, a novel method, based on the utilization of artificial neural…

Computer Vision and Pattern Recognition · Computer Science 2018-06-12 Max Frei , Frank Einar Kruis

The paper presents an alternative way to classical stereocorrelation. First, 2D image processing of random patterns is described. Sub-pixel displacements are determined using phase analysis. Then distortion evaluation is presented. The…

Classical Physics · Physics 2013-11-18 Jérôme Molimard , Gaetan Boyer , Hassan Zahouani

Due to the lack of a definitive ground truth for the image fusion problem, the loss functions are structured based on evaluation metrics, such as the structural similarity index measure (SSIM). However, in doing so, a bias is introduced…

Computer Vision and Pattern Recognition · Computer Science 2024-04-25 Aytekin Erdogan , Erdem Akagündüz

Automated label-free quantitative imaging of biological samples can greatly benefit high throughput diseases diagnosis. Digital holographic microscopy (DHM) is a powerful quantitative label-free imaging tool that retrieves structural…

Two-Photon Laser-Scanning Microscopy is a powerful tool for exploring biological structure and function because of its ability to optically section through a sample with a tight focus. While it is possible to obtain 3D image stacks by…

Biological Physics · Physics 2020-01-08 Courtney Johnson , Jack Exell , Jonathon Kuo , Kevin Welsher

Frozen sectioning (FS) is the preparation method of choice for microscopic evaluation of tissues during surgical operations. The high speed of the procedure allows pathologists to rapidly assess the key microscopic features, such as tumour…

To provide optimal depth resolution with a coded-aperture Laue diffraction microscope, an accurate position of the coded-aperture and its scanning geometry need to be known. However, finding the geometry by trial and error is a…

Image and Video Processing · Electrical Eng. & Systems 2023-02-02 Doga Gursoy , Dina Sheyfer , Michael Wojcik , Wenjun Liu , Jonathan Tischler

We propose an efficient algorithm to analyze $3D$ atomic resolution crystal images based on a fast $3D$ synchrosqueezed wave packet transform. The proposed algorithm can automatically extract microscopic information from $3D$ atomic…

Numerical Analysis · Mathematics 2018-11-14 Tao Zhang , Ling Li , Haizhao Yang

In the imaging process of an astronomical telescope, the deconvolution of its beam or Point Spread Function (PSF) is a crucial task. However, deconvolution presents a classical and challenging inverse computation problem. In scenarios where…

Instrumentation and Methods for Astrophysics · Physics 2024-03-05 Shulei Ni , Yisheng Qiu , Yunchun Chen , Zihao Song , Hao Chen , Xuejian Jiang , Huaxi Chen

Flow-Imaging Microscopy (FIM) is commonly used in both academia and industry to characterize subvisible particles (those $\le 25 \mu m$ in size) in protein therapeutics. Pharmaceutical companies are required to record vast volumes of FIM…

Quantitative Methods · Quantitative Biology 2017-09-04 Christopher P. Calderon , Austin L. Daniels , Theodore W. Randolph

Existing methods for image alignment struggle in cases involving feature-sparse regions, extreme scale and field-of-view differences, and large deformations, often resulting in suboptimal accuracy. Robustness to these challenges can be…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Kanggeon Lee , Soochahn Lee , Kyoung Mu Lee

Scanning transmission electron microscopy is a common tool used to study the atomic structure of materials. It is an inherently multimodal tool allowing for the simultaneous acquisition of multiple information channels. Despite its…

Fourier ptychographic (FP) microscope is a coherent imaging method that can synthesize an image with a higher bandwidth using multiple low-bandwidth images captured at different spatial frequency regions. The method's demand for multiple…

Optics · Physics 2016-03-25 Jaebum Chung , Hangwen Lu , Xiaoze Ou , Haojiang Zhou , Changhuei Yang

The quality control of fetal sonographic (FS) images is essential for the correct biometric measurements and fetal anomaly diagnosis. However, quality control requires professional sonographers to perform and is often labor-intensive. To…

Computer Vision and Pattern Recognition · Computer Science 2019-12-12 Hong Luo , Han Liu , Kejun Li , Bo Zhang

Modern data analysis frequently involves variables with highly non-Gaussian marginal distributions. However, commonly used analysis methods are most effective with roughly Gaussian data. This paper introduces an automatic transformation…

Methodology · Statistics 2016-01-11 Qing Feng , Jan Hannig , J. S. Marron

In x-ray microscopy, traditional raster-scanning techniques are used to acquire a microscopic image in a series of step-scans. Alternatively, scanning the x-ray probe along a continuous path, called a fly-scan, reduces scan time and…

Image and Video Processing · Electrical Eng. & Systems 2025-09-23 Yu Lu , Thomas F. Lynn , Ming Du , Zichao Di , Sven Leyffer

Microscopy is one of the most essential imaging techniques in life sciences. High-quality images are required in order to solve (potentially life-saving) biomedical research problems. Many microscopy techniques do not achieve sufficient…

Computer Vision and Pattern Recognition · Computer Science 2018-10-24 Joris Roels , Jan Aelterman , Jonas De Vylder , Hiep Luong , Yvan Saeys , Wilfried Philips

The science of solving clinical problems by analyzing images generated in clinical practice is known as medical image analysis. The aim is to extract information in an effective and efficient manner for improved clinical diagnosis. The…

Computer Vision and Pattern Recognition · Computer Science 2019-05-22 Syed Muhammad Anwar , Muhammad Majid , Adnan Qayyum , Muhammad Awais , Majdi Alnowami , Muhammad Khurram Khan