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Persistent homology (PH) is a popular tool for topological data analysis that has found applications across diverse areas of research. It provides a rigorous method to compute robust topological features in discrete experimental…

Machine Learning · Computer Science 2023-07-19 Manu Aggarwal , Vipul Periwal

A suitable feature representation that can both preserve the data intrinsic information and reduce data complexity and dimensionality is key to the performance of machine learning models. Deeply rooted in algebraic topology, persistent…

Algebraic Topology · Mathematics 2018-11-02 Chi Seng Pun , Kelin Xia , Si Xian Lee

Proteins are the most important biomolecules for living organisms. The understanding of protein structure, function, dynamics and transport is one of most challenging tasks in biological science. In the present work, persistent homology is,…

Biomolecules · Quantitative Biology 2014-12-10 Kelin Xia , Guo-Wei Wei

Self-assembly of polymers at liquid interfaces using non-covalent interactions has emerged as a promising technique to reversibly produce self-healing membranes. Besides the assembly process, it is also crucial to control the mechanical…

Machine learning for point clouds has been attracting much attention, with many applications in various fields, such as shape recognition and material science. For enhancing the accuracy of such machine learning methods, it is often…

Machine Learning · Computer Science 2023-12-29 Naoki Nishikawa , Yuichi Ike , Kenji Yamanishi

Persistent homology computes the multiscale topology of a data set by using a sequence of discrete complexes. In this paper, we propose that persistent homology may be a useful tool for studying the structure of the landscape of string…

High Energy Physics - Theory · Physics 2019-04-24 Alex Cole , Gary Shiu

Spatial relationships in multi-species data can indicate and affect system outcomes and behaviors, ranging from disease progression in cancer to coral reef resilience in ecology; therefore, quantifying these relationships is an important…

Granular materials exhibit intricate force networks, often concentrated in chains rather than being uniformly distributed. These meso-scale structures are complex to characterize, owing to their heterogeneous and anisotropic nature. We…

Soft Condensed Matter · Physics 2025-08-06 S Vishali , Abrar Naseer , Vijay Natarajan , Tejas G Murthy

Motivation: Site directed mutagenesis is widely used to understand the structure and function of biomolecules. Computational prediction of protein mutation impacts offers a fast, economical and potentially accurate alternative to laboratory…

Quantitative Methods · Quantitative Biology 2017-04-03 Zixuan Cang , Guo-Wei Wei

In medical image analysis, feature engineering plays an important role in the design and performance of machine learning models. Persistent homology (PH), from the field of topological data analysis (TDA), demonstrates robustness and…

Computer Vision and Pattern Recognition · Computer Science 2025-06-05 Dashti A. Ali , Richard K. G. Do , William R. Jarnagin , Aras T. Asaad , Amber L. Simpson

Polymer physics models suggest that chromatin spontaneously folds into loop networks with transcription units (TUs), such as enhancers and promoters, as anchors. Here we use combinatoric arguments to enumerate the emergent chromatin loop…

Biological Physics · Physics 2023-12-20 Andrea Bonato , Dom Corbett , Sergey Kitaev , Davide Marenduzzo , Alexander Morozov , Enzo Orlandini

Persistent Homology (PH) is a fundamental tool in computational topology, designed to uncover the intrinsic geometric and topological features of data across multiple scales. Originating within the broader framework of Topological Data…

Algebraic Topology · Mathematics 2025-05-13 Aurelie Jodelle Kemme , Collins Amburo Agyingi

Persistent homology is a powerful tool for characterizing the topology of a data set at various geometric scales. When applied to the description of molecular structures, persistent homology can capture the multiscale geometric features and…

Quantitative Methods · Quantitative Biology 2018-07-31 Zixuan Cang , Guo-Wei Wei

Persistent homology (PH) is a recently developed theory in the field of algebraic topology to study shapes of datasets. It is an effective data analysis tool that is robust to noise and has been widely applied. We demonstrate a general…

Signal Processing · Electrical Eng. & Systems 2020-05-05 Yu-Min Chung , Chuan-Shen Hu , Yu-Lun Lo , Hau-Tieng Wu

Topological data analysis can reveal higher-order structure beyond pairwise connections between vertices in complex networks. We present a new method based on discrete Morse theory to study topological properties of unweighted and…

Discrete Mathematics · Computer Science 2019-10-01 Harish Kannan , Emil Saucan , Indrava Roy , Areejit Samal

As amorphous materials get jammed, both geometric and dynamic heterogeneity are observed. We investigate the correlation between the local geometric heterogeneity and local rearrangements in a slowly compressed bidisperse…

Soft Condensed Matter · Physics 2024-03-21 Xin Du , Eric R. Weeks

Topological constraints (TCs) between polymers determine the behaviour of complex fluids such as creams, oils and plastics. Most of the polymer solutions used every day life employ linear chains; their behaviour is accurately captured by…

Soft Condensed Matter · Physics 2020-10-07 Fabio Landuzzi , Takenobu Nakamura , Davide Michieletto , Takahiro Sakaue

This paper concerns a theoretical approach that combines topological data analysis (TDA) and sheaf theory. Topological data analysis, a rising field in mathematics and computer science, concerns the shape of the data and has been proven…

Computer Vision and Pattern Recognition · Computer Science 2020-12-04 Chuan-Shen Hu , Yu-Min Chung

As complex networks find applications in a growing range of disciplines, the diversity of naturally occurring and model networks being studied is exploding. The adoption of a well-developed collection of network taxonomies is a natural…

Combinatorics · Mathematics 2016-01-25 Ann Sizemore , Chad Giusti , Danielle Bassett

We have carried out experiments to probe the static and dynamic interfacial properties of $\beta$--casein monolayers spread at the air-buffer interface, and analysed these results in the context of models of weak polyampholytes.…

Soft Condensed Matter · Physics 2009-11-07 Pietro Cicuta , Ian Hopkinson