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Consolidation of synaptic changes in response to neural activity is thought to be fundamental for memory maintenance over a timescale of hours. In experiments, synaptic consolidation can be induced by repeatedly stimulating presynaptic…

Neurons and Cognition · Quantitative Biology 2019-11-14 Chiara Gastaldi , Samuel P. Muscinelli , Wulfram Gerstner

The efficiency of modern machine intelligence depends on high accuracy with minimal computational cost. In spiking neural networks (SNNs), synaptic delays are crucial for encoding temporal structure, yet existing models treat them as fully…

Neural and Evolutionary Computing · Computer Science 2025-12-19 Lennart P. L. Landsmeer , Amirreza Movahedin , Mario Negrello , Said Hamdioui , Christos Strydis

We report new statistical time-series analysis tools providing significant improvements in the rapid, precision extraction of discrete state dynamics from large databases of experimental observations of molecular machines. By building…

Quantitative Methods · Quantitative Biology 2019-10-23 Max A. Little , Bradley C. Steel , Fan Bai , Yoshiyuki Sowa , Thomas Bilyard , David M. Mueller , Richard M. Berry , Nick S. Jones

Empirical Dynamic Modeling (EDM) is a nonlinear time series causal inference framework. The latest implementation of EDM, cppEDM, has only been used for small datasets due to computational cost. With the growth of data collection…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-11-24 Wassapon Watanakeesuntorn , Keichi Takahashi , Kohei Ichikawa , Joseph Park , George Sugihara , Ryousei Takano , Jason Haga , Gerald M. Pao

In this paper we combine the Parareal parallel-in-time method together with spatial parallelization and investigate this space-time parallel scheme by means of solving the three-dimensional incompressible Navier-Stokes equations.…

Computational Engineering, Finance, and Science · Computer Science 2017-05-18 Roberto Croce , Daniel Ruprecht , Rolf Krause

We revisit the planning problem in the blocks world, and we implement a known heuristic for this task. Importantly, our implementation is biologically plausible, in the sense that it is carried out exclusively through the spiking of…

Artificial Intelligence · Computer Science 2022-11-22 Francesco d'Amore , Daniel Mitropolsky , Pierluigi Crescenzi , Emanuele Natale , Christos H. Papadimitriou

Spiking neural networks (SNNs) promise low-power event-driven computation for temporally rich tasks, but commonly used neuron models often trade off gradient-based trainability, dynamical richness, and high activity sparsity. These…

Neural and Evolutionary Computing · Computer Science 2026-05-13 Alex Fulleda-Garcia , Saray Soldado-Magraner , Josep Maria Margarit-Taulé

This paper presents a comparative analysis of distributed training strategies for large-scale neural networks, focusing on data parallelism, model parallelism, and hybrid approaches. We evaluate these strategies on image classification…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-01 Vishnu Vardhan Baligodugula , Fathi Amsaad

Learning is based on synaptic plasticity, which affects and is driven by neural activity. Because pre- and postsynaptic spiking activity is shaped by randomness, the synaptic weights follow a stochastic process, requiring a probabilistic…

Neurons and Cognition · Quantitative Biology 2026-01-14 Jakob Stubenrauch , Naomi Auer , Richard Kempter , Benjamin Lindner

Filtered shot noise processes have proven to be very effective in modelling the evolution of systems exposed to stochastic shot noise sources, and have been applied to a wide variety of fields ranging from electronics through biology. In…

Neurons and Cognition · Quantitative Biology 2015-09-15 Marco Brigham , Alain Destexhe

Emerging workloads, such as graph processing and machine learning are approximate because of the scale of data involved and the stochastic nature of the underlying algorithms. These algorithms are often distributed over multiple machines…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-12-28 Asim Kadav , Erik Kruus

The computational inefficiency of spiking neural networks (SNNs) is primarily due to the sequential updates of membrane potential, which becomes more pronounced during extended encoding periods compared to artificial neural networks (ANNs).…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Hanqi Chen , Lixing Yu , Shaojie Zhan , Penghui Yao , Jiankun Shao

Massively parallel hardware (GPUs) and long sequence data have made parallel algorithms essential for machine learning at scale. Yet dynamical systems, like recurrent neural networks and Markov chain Monte Carlo, were thought to suffer from…

Numerical Analysis · Mathematics 2026-03-18 Xavier Gonzalez

Neural activity exhibits a vast range of timescales that can be several fold larger than the membrane time constant of individual neurons. Two types of mechanisms have been proposed to explain this conundrum. One possibility is that large…

Neurons and Cognition · Quantitative Biology 2019-03-26 Manuel Beiran , Srdjan Ostojic

Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands…

Dynamical systems are often time-varying, whose modeling requires a function that evolves with respect to time. Recent studies such as the neural ordinary differential equation proposed a time-dependent neural network, which provides a…

Machine Learning · Computer Science 2024-05-24 Bum Jun Kim , Yoshinobu Kawahara , Sang Woo Kim

Anisotropic mesh adaptation is a powerful way to directly minimise the computational cost of mesh based simulation. It is particularly important for multi-scale problems where the required number of floating-point operations can be reduced…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-08-13 Georgios Rokos , Gerard J. Gorman , James Southern , Paul H. J. Kelly

The experimental study of neural networks requires simultaneous measurements of a massive number of neurons, while monitoring properties of the connectivity, synaptic strengths and delays. Current technological barriers make such a mission…

Neurons and Cognition · Quantitative Biology 2016-01-12 Amir Goldental , Pinhas Sabo , Shira Sardi , Roni Vardi , Ido Kanter

Continuous-time models are a natural choice for irregular and asynchronous data. A central design choice is how to embed discrete observations into continuous time. Interpolation- and imputation-based embeddings reconstruct a continuous…

Machine Learning · Computer Science 2026-05-29 Benjamin Walker , Alexandre Bloch , Lingyi Yang , Sam Morley , Terry Lyons

Neuromorphic computing systems comprise networks of neurons that use asynchronous events for both computation and communication. This type of representation offers several advantages in terms of bandwidth and power consumption in…

Hardware Architecture · Computer Science 2017-11-07 Saber Moradi , Ning Qiao , Fabio Stefanini , Giacomo Indiveri