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We present a computational modeling framework for data-driven simulations and analysis of infectious disease spread in large populations. For the purpose of efficient simulations, we devise a parallel solution algorithm targeting…

Populations and Evolution · Quantitative Biology 2018-02-19 Pavol Bauer , Stefan Engblom , Stefan Widgren

Most contemporary neural learning systems rely on epoch-based optimization and repeated access to historical data, implicitly assuming reversible computation. In contrast, real-world environments often present information as irreversible…

Neural and Evolutionary Computing · Computer Science 2026-02-26 Amama Pathan

Neural networks can synchronize by learning from each other. In the case of discrete weights full synchronization is achieved in a finite number of steps. Additional networks can be trained by using the inputs and outputs generated during…

Disordered Systems and Neural Networks · Physics 2007-11-16 Andreas Ruttor

Parallel dataflow systems are a central part of most analytic pipelines for big data. The iterative nature of many analysis and machine learning algorithms, however, is still a challenge for current systems. While certain types of bulk…

Databases · Computer Science 2012-08-02 Stephan Ewen , Kostas Tzoumas , Moritz Kaufmann , Volker Markl

Spiking Neural P systems, SNP systems for short, are biologically inspired computing devices based on how neurons perform computations. SNP systems use only one type of symbol, the spike, in the computations. Information is encoded in the…

Neural and Evolutionary Computing · Computer Science 2012-10-24 Francis George C. Cabarle , Kelvin C. Buño , Henry N. Adorna

Stochastic models of biochemical reaction networks are widely used to capture intrinsic noise in cellular systems. The typical formulation of these models are based on Markov processes for which there is extensive research on efficient…

Molecular Networks · Quantitative Biology 2025-12-03 Thomas P. Steele , David J. Warne

Volunteer computing is being used successfully for large scale scientific computations. This research is in the context of Volpex, a programming framework that supports communicating parallel processes in a volunteer environment. Redundancy…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-03-14 Mohammad Tanvir Rahman , Hien Nguyen , Jaspal Subhlok , Gopal Pandurangan

Spiking Neural Networks (SNNs) are extensively utilized in brain-inspired computing and neuroscience research. To enhance the speed and energy efficiency of SNNs, several many-core accelerators have been developed. However, maintaining the…

Neural and Evolutionary Computing · Computer Science 2024-07-31 Zhuo Chen , De Ma , Xiaofei Jin , Qinghui Xing , Ouwen Jin , Xin Du , Shuibing He , Gang Pan

For simulating large networks of neurons Hines proposed a method which uses extensively the structure of the arising systems of ordinary differential equations in order to obtain an efficient implementation. The original method requires…

Numerical Analysis · Mathematics 2017-03-27 Michael Hanke

The training of deep neural networks is inherently a nonconvex optimization problem, yet standard approaches such as stochastic gradient descent (SGD) require simultaneous updates to all parameters, often leading to unstable convergence and…

Machine Learning · Computer Science 2025-08-07 Chengcheng Yan , Jiawei Xu , Zheng Peng , Qingsong Wang

Neural synchrony in the brain at rest is usually variable and intermittent, thus intervals of predominantly synchronized activity are interrupted by intervals of desynchronized activity. Prior studies suggested that this temporal structure…

Quantitative Methods · Quantitative Biology 2021-04-26 Joel Zirkle , Leonid L Rubchinsky

We study the synchronous dynamics of the Hopfield model when a random antisymmetric part is added to the otherwise symmetric synaptic matrix. We use a generating functional technique to derive analytical expressions for the order parameters…

Disordered Systems and Neural Networks · Physics 2007-05-23 Manoranjan P. Singh

Bayesian networks (BNs) are a widely used graphical model in machine learning for representing knowledge with uncertainty. The mainstream BN structure learning methods require performing a large number of conditional independence (CI)…

Machine Learning · Computer Science 2022-12-09 Jiantong Jiang , Zeyi Wen , Ajmal Mian

Networks of neural mass nodes with delayed interactions are increasingly being used as models for large-scale brain activity. To complement the growing number of computational studies of such networks, it is timely to develop new…

Dynamical Systems · Mathematics 2025-09-29 S Coombes , H G E Meijer

The availability of large-scale neuronal population datasets necessitates new methods to model population dynamics and extract interpretable, scientifically translatable insights. Existing deep learning methods often overlook the biological…

Neurons and Cognition · Quantitative Biology 2024-11-14 Parsa Delavari , Ipek Oruc , Timothy H Murphy

As the artificial intelligence community advances into the era of large models with billions of parameters, distributed training and inference have become essential. While various parallelism strategies-data, model, sequence, and…

Machine Learning · Computer Science 2025-03-13 Ruifeng She , Bowen Pang , Kai Li , Zehua Liu , Tao Zhong

We introduce a natively distributed mini-application benchmark representative of plastic spiking neural network simulators. It can be used to measure performances of existing computing platforms and to drive the development of future…

The modeling and simulation of coupled neuromusculoskeletal-exoskeletal systems play a crucial role in human biomechanical analysis, as well as in the design and control of exoskeletons. However, conventional dynamic simulation frameworks…

Robotics · Computer Science 2023-11-07 Wei Jin , Jiaqi Liu , Qiwei Zhang , Xiaoxu Zhang , Qining Wang , Hongbin Fang , Jian Xu

In the last century, most sensorimotor studies of cortical neurons relied on average firing rates. Rate coding is efficient for fast sensorimotor processing that occurs within a few seconds. Much less is known about the neural mechanisms…

Neurons and Cognition · Quantitative Biology 2026-05-01 Terrence J. Sejnowski

Maximum entropy methods provide a principled path connecting measurements of neural activity directly to statistical physics models, and this approach has been successful for populations of $N\sim 100$ neurons. As $N$ increases in new…

Biological Physics · Physics 2023-10-18 Christopher W. Lynn , Qiwei Yu , Rich Pang , William Bialek , Stephanie E. Palmer