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Time series of conformational dynamics in proteins are usually evaluated with hidden Markov models (HMMs). This approach works well if the number of states and their connectivity is known. However, for the multi-domain protein Hsp90, a…

This paper presents a distributed stochastic model predictive control (SMPC) approach for large-scale linear systems with private and common uncertainties in a plug-and-play framework. Using the so-called scenario approach, the centralized…

Optimization and Control · Mathematics 2019-01-09 V. Rostampour , T. Keviczky

The well-established methodology for the estimation of hidden semi-Markov models (HSMMs) as hidden Markov models (HMMs) with extended state spaces is further developed to incorporate covariate influences across all aspects of the state…

Methodology · Statistics 2024-05-24 Jan-Ole Koslik

Markov chains provide a foundational framework for modeling sequential stochastic processes, with the transition probability matrix characterizing the dynamics of state evolution. While classical estimation methods such as maximum…

Methodology · Statistics 2025-07-11 Agamani Saha , Souvik Roy

Hidden Markov Models (HMMs) are a ubiquitous tool to model time series data, and have been widely used in two main tasks of Automatic Music Transcription (AMT): note segmentation, i.e. identifying the played notes after a multi-pitch…

Machine Learning · Statistics 2017-04-13 D. Cazau , G. Nuel

Recent years have seen substantial advances in the development of biofunctional materials using synthetic polymers. The growing problem of elusive sequence-functionality relations for most biomaterials has driven researchers to seek more…

Quantitative Methods · Quantitative Biology 2022-07-06 Yun Zhou , Boying Gong , Tao Jiang , Ting Xu , Haiyan Huang

We provide a comprehensive overview of latent Markov (LM) models for the analysis of longitudinal categorical data. The main assumption behind these models is that the response variables are conditionally independent given a latent process…

Statistics Theory · Mathematics 2010-03-16 F. Bartolucci , A. Farcomeni , F. Pennoni

High amplitude impulsive noise (IN) occurrence over power line channels severely degrades the performance of Orthogonal Frequency Division Multiplexing (OFDM)systems. One of the simplest methods to reduce IN is to precede the OFDM…

Signal Processing · Electrical Eng. & Systems 2018-07-18 Ferheen Ayaz , Khaled Rabie , Bamidele Adebisi

This report describes a new technique for inducing the structure of Hidden Markov Models from data which is based on the general `model merging' strategy (Omohundro 1992). The process begins with a maximum likelihood HMM that directly…

cmp-lg · Computer Science 2008-02-03 Andreas Stolcke , Stephen M. Omohundro

This paper studies the robustness of quasi-maximum-likelihood (QML) estimation in hidden Markov models (HMMs) when the regime-switching structure is misspecified. Specifically, we examine the case where the true data-generating process…

Econometrics · Economics 2026-01-14 Demian Pouzo , Martin Sola , Zacharias Psaradakis

The paper is devoted to studies of perturbed Markov chains commonly used for description of information networks. In such models, the matrix of transition probabilities for the corresponding Markov chain is usually regularised by adding a…

B-spline-based hidden Markov models employ B-splines to specify the emission distributions, offering a more flexible modelling approach to data than conventional parametric HMMs. We introduce a Bayesian framework for inference, enabling the…

Methodology · Statistics 2023-10-03 Sida Chen , Bärbel Finkenstädt Rand

We present a data-driven model predictive control scheme for chance-constrained Markovian switching systems with unknown switching probabilities. Using samples of the underlying Markov chain, ambiguity sets of transition probabilities are…

Optimization and Control · Mathematics 2020-10-02 Mathijs Schuurmans , Panagiotis Patrinos

Markov population models (MPMs) are a widely used modelling formalism in the area of computational biology and related areas. The semantics of a MPM is an infinite-state continuous-time Markov chain. In this paper, we use the established…

Numerical Analysis · Computer Science 2014-06-10 David Spieler , Ernst Moritz Hahn , Lijun Zhang

We present a learning model predictive control (MPC) scheme for chance-constrained Markov jump systems with unknown switching probabilities. Using samples of the underlying Markov chain, ambiguity sets of transition probabilities are…

Optimization and Control · Mathematics 2023-01-06 Mathijs Schuurmans , Panagiotis Patrinos

This paper proposes a computationally efficient method of solving evaluation problem of Hidden Markov Model (HMM) with a given set of discrete observation symbols, number of states and probability distribution matrices. The observation…

Data Structures and Algorithms · Computer Science 2012-02-29 R. Gnanajeyaraman , G. Seenivasan

We are interested in enabling autonomous agents to learn and reason about systems with hidden states, such as locking mechanisms. We cast this problem as learning the parameters of a discrete Partially Observable Markov Decision Process…

Machine Learning · Computer Science 2026-02-04 Seiji Shaw , Travis Manderson , Chad Kessens , Nicholas Roy

Stochastic gradient MCMC (SG-MCMC) algorithms have proven useful in scaling Bayesian inference to large datasets under an assumption of i.i.d data. We instead develop an SG-MCMC algorithm to learn the parameters of hidden Markov models…

Machine Learning · Statistics 2017-06-16 Yi-An Ma , Nicholas J. Foti , Emily B. Fox

A state space representation of an environment is a classic and yet powerful tool used by many autonomous robotic systems for efficient and often optimal solution planning. However, designing these representations with high performance is…

Machine Learning · Computer Science 2020-12-23 Andrew Wilhelm , Aaron Wilhelm , Garrett Fosdick

Embarrassingly (communication-free) parallel Markov chain Monte Carlo (MCMC) methods are commonly used in learning graphical models. However, MCMC cannot be directly applied in learning topic models because of the quasi-ergodicity problem…

Machine Learning · Computer Science 2017-08-11 Lee Gao , Ronghuo Zheng