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Mycobacterium leprae is a bacteria that causes the disease Leprosy (Hansen's disease), which is a neglected tropical disease. More than 200000 cases are being reported per year world wide. This disease leads to a chronic stage known as…
The renal vasculature, acting as a resource distribution network, plays an important role in both the physiology and pathophysiology of the kidney. However, no imaging techniques allow an assessment of the structure and function of the…
Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is…
Early and accurate diagnosis of pulmonary hypertension (PH) is essential for optimal patient management. Differentiating between pre-capillary and post-capillary PH is critical for guiding treatment decisions. This study develops and…
Vagus Nerve Stimulation (VNS) is an established palliative treatment for drug resistant epilepsy. While effective for many patients, its mechanism of action is incompletely understood. Predicting individuals' response, or optimum…
Information about autonomic nervous system (ANS) activity may be valuable for personalized atrial fibrillation (AF) treatment but is not easily accessible from the ECG. In this study, we propose a new approach for ECG-based assessment of…
Human and humanoid posture control models usually rely on single or multiple degrees of freedom inverted pendulum representation of upright stance associated with a feedback controller. In models typically focused on the action between…
We present a Cortical Neural Pool (CNP) architecture featuring a high-speed, resource-efficient CORDIC based Hodgkin-Huxley (RCHH) neuron model. Unlike shared CORDIC-based DNN approaches, the proposed neuron leverages modular and…
Background: Acute kidney injury (AKI) is a common complication in hospitalized patients and a common cause for chronic kidney disease (CKD) and increased hospital cost and mortality. By timely detection of AKI and AKI progression, effective…
Noise-delayed decay (NDD) phenomenon emerges when the first-spike latency of a periodically forced stochastic neuron exhibits a maximum for a particular range of noise intensity. Here, we investigate the latency response dynamics of a…
Many central neurons, and in particular certain brainstem aminergic neurons exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz. A large number of ion channel types contribute to such spiking so that accurate…
In this work, we investigated the effect of varying strength of Hyperkalemia and Hypoxia, in human cardiac tissue with a local ischemic subregion, on the electrical and mechanical activity of healthy and ischemic zones of the cardiac…
This investigation aims to assess the effect of different types of actuator forcing on the feedback loop of an under-expanded Mach 1.27 planar impinging jet using a resolvent framework. To this end, we employ a Large Eddy Simulation…
Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…
Existing methods for arterial blood pressure (BP) estimation directly map the input physiological signals to output BP values without explicitly modeling the underlying temporal dependencies in BP dynamics. As a result, these models suffer…
This study investigates the speech articulatory coordination in schizophrenia subjects exhibiting strong positive symptoms (e.g. hallucinations and delusions), using two distinct channel-delay correlation methods. We show that the…
Focal cortical dysplasia (FCD) type II is a major cause of drug-resistant epilepsy, often curable only by surgery. Despite its clinical importance, the diagnosis of FCD is very difficult in MRI because of subtle abnormalities, leading to…
We have performed Co-nuclear quadrupole resonance (NQR) studies on Na$_{x}$CoO$_{2}\cdot y$H$_{2}$O compounds with different Na ($x$) and hydrate ($y$) contents. Two samples with different Na contents but nearly the same $T_c$ values ($x$ =…
Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as a consequence of chronic liver disease. Alterations in energy metabolism have been suggested in type C HE, but $\textit{in vivo}$ studies on this matter…
Objective: To increase the impedance signal amplitude produced during neural activity using a novel approach of implementing a parallel resistor inductor capacitor (RLC) circuit across the current source used in electrical impedance…