Related papers: Respiratory sympathetic modulation is augmented in…
In this paper, we present a unified framework for various bio-inspired models to better understand their structural and functional differences. We show that liquid-capacitance-extended models lead to interpretable behavior even in dense,…
Type 2 diabetes (T2D) is closely linked with non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance, but the involved mechanisms are still elusive. Using DNA methylome and transcriptome analyses of livers from obese…
Objective: To improve prediction of Chronic Kidney Disease (CKD) progression to End Stage Renal Disease (ESRD) using machine learning (ML) and deep learning (DL) models applied to an integrated clinical and claims dataset of varying…
Serotonergic, noradrenergic and dopaminergic brainstem (including midbrain) neurons, often exhibit spontaneous and fairly regular spiking with frequencies of order a few Hz, though dopaminergic and noradrenergic neurons only exhibit such…
Acute Kidney Injury (AKI), the abrupt decline in kidney function due to temporary or permanent injury, is associated with increased mortality, morbidity, length of stay, and hospital cost. Sometimes, simple interventions such as medication…
Pump-probe experiments performed on $\mathrm{K}_3\mathrm{C}_{60}$ have unveiled both optical and transport signatures of metastable light-induced superconductivity up to room temperature, far above $T_c$. Recent experiments have uncovered…
Chronic Kidney Disease (CKD), where delayed recognition implies premature mortality, is currently experiencing a globally increasing incidence and high cost to health systems. Data mining allows discovering subtle patterns in CKD indicators…
Autonomic nervous system is important for cardiac function regulation. Modeling of autonomic cardiac regulation can contribute to health tracking and disease management. This study proposed a mathematical model that simulates autonomic…
Recent trials of a neuronal pacemaker have shown that cardiac pumping efficiency increases when respiratory sinus arrhythmia (RSA) is artificially restored in animal models of heart failure. This novel device sheds new light on the…
Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease that leads to increased pulmonary pressures, vascular remodeling, and eventual right ventricular (RV) failure. Pediatric PAH remains understudied due to limited…
Objective: Hepatic encephalopathy (HE) is a potentially reversible brain dysfunction caused by liver failure. Altered synaptic plasticity is supposed to play a major role in the pathophysiology of HE. Here, we used paired associative…
BACKGROUND: An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic…
The complexity of a signal can be measured by the Recurrence period density entropy (RPDE) from the reconstructed phase space. We have chosen a window based RPDE method for the classification of signals, as RPDE is an average entropic…
Background. Clinical parameters measured from gated single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) have value in predicting cardiac resynchronization therapy (CRT) patient outcomes, but still show…
Parkinson's disease is marked by altered and increased firing characteristics of pathological oscillations in the brain. In other words, it causes abnormal synchronous oscillations and suppression during neurological processing. In order to…
The neuron consumes energy from ATP hydrolysis to maintain a far-from-equilibrium steady state inside the cell, thus all physiological functions inside the cell are modulated by thermodynamics. The neurons that manage information encoding,…
Neurovascular coupling (NVC) refers to the process by which local neural activity, through energy consumption, induces changes in regional cerebral blood flow to meet the metabolic demands of neurons. Event-related studies have shown that…
Atomic-scale disorder is conventionally regarded as detrimental to superconductivity; however, under specific conditions, it can enhance superconducting properties. Here, we investigate the role of substitutional disorder in Remeika-type…
Chronic kidney disease (CKD) affects millions worldwide and progresses irreversibly through stages culminating in end-stage renal disease (ESRD) and death. Outcome trials in CKD traditionally employ time-to-first-event analyses using the…
Cardiovascular diseases (CVDs) are notably prevalent among patients with obstructive sleep apnea (OSA), posing unique challenges in predicting CVD progression due to the intricate interactions of comorbidities. Traditional models typically…