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Cell-cell adhesion is an inherently nonlocal phenomenon. Numerous partial differential equation models with nonlocal term have been recently presented to describe this phenomenon, yet the mathematical properties of nonlocal adhesion model…

Analysis of PDEs · Mathematics 2021-03-17 Jaewook Ahn , Myeongju Chae , Jihoon Lee

In this manuscript, we consider the modelling of cellular adhesions, which is a key interaction between biological cells. Continuum models of the diffusion-advection-reaction type have long been used in tissue modelling. In 2006, Armstrong,…

Analysis of PDEs · Mathematics 2020-01-03 Andreas Buttenschön , Thomas Hillen

Cell-cell adhesion is one the most fundamental mechanisms regulating collective cell migration during tissue development, homeostasis and repair, allowing cell populations to self-organize and eventually form and maintain complex tissue…

Cell Behavior · Quantitative Biology 2022-11-16 Carles Falcó , Ruth E. Baker , José A. Carrillo

Cell-cell adhesion plays a vital role in the development and maintenance of multicellular organisms. One of its functions is regulation of cell migration, such as occurs, e.g. during embryogenesis or in cancer. In this work, we develop a…

Tissues and Organs · Quantitative Biology 2024-03-08 Anna Zhigun , Mabel Lizzy Rajendran

Over the past decades, nonlocal models have been widely used to describe aggregation phenomena in biology, physics, engineering, and the social sciences. These are often derived as mean-field limits of attraction-repulsion agent-based…

Cell Behavior · Quantitative Biology 2025-05-14 Carles Falcó , Ruth E. Baker , José A. Carrillo

Local well-posedness is established for a highly nonlocal nonlinear diffusion-adhesion system for bounded initial values with small support. Macroscopic systems of this kind were previously obtained by the authors through upscaling in [32]…

Analysis of PDEs · Mathematics 2025-05-16 Mabel Lizzy Rajendran , Anna Zhigun

We discuss several continuum cell-cell adhesion models based on the underlying microscopic assumptions. We propose an improvement on these models leading to sharp fronts and intermingling invasion fronts between different cell type…

Cell Behavior · Quantitative Biology 2019-01-11 Jose A. Carrillo , Hideki Murakawa , Makoto Sato , Hideru Togashi , Olena Trush

The main purpose of this work is the mathematical modelling of large populations of cells under different deterministic interactions among themselves, in balance with naturally random diffusion. We focus on cell-cell adhesion mechanisms for…

Analysis of PDEs · Mathematics 2025-03-19 Carlo Giambiagi Ferrari , Francisco Guillen-Gonzalez , Mayte Perez-Llanos , Antonio Suarez

In this paper we address the analytical investigation of a model for adhesive contact, which includes nonlocal sources of damage on the contact surface, such as the elongation. The resulting PDE system features various nonlinearities…

Analysis of PDEs · Mathematics 2017-04-04 Elena Bonetti , Giovanna Bonfanti , Riccarda Rossi

We investigate a continuum mechanical model for an adherent cell on two dimensional adhesive micropatterned substrates. The cell is modeled as an isotropic and homogeneous elastic material subject to uniform internal contractile stresses.…

Biological Physics · Physics 2013-12-30 Shiladitya Banerjee , Rastko Sknepnek , M. Cristina Marchetti

We report on the modeling of the dynamics of confined lipid membranes. We derive a thin film model in the lubrication limit which describes an inextensible liquid membrane with bending rigidity confined between two adhesive walls. The…

Soft Condensed Matter · Physics 2018-08-02 Tung B. T. To , Thomas Le Goff , Olivier Pierre-Louis

We study the (generalized) one-dimensional population model developed by Anguige \& Schmeiser [1], which reflects cell-cell adhesion and volume filling under no-flux boundary condition. In this generalized model, depending on the adhesion…

Analysis of PDEs · Mathematics 2024-09-11 Hyung Jun Choi , Seonghak Kim , Youngwoo Koh

We review theoretical results for the adhesion-induced phase behavior of biomembranes. The focus is on models in which the membranes are represented as discretized elastic sheets with embedded adhesion molecules. We present several…

Soft Condensed Matter · Physics 2007-09-25 Thomas R. Weikl , Reinhard Lipowsky

Global existence of very weak solutions to a non-local diffusion-advection-reaction equation is established under no-flux boundary conditions in higher dimensions. The equation features degenerate myopic diffusion and nonlocal adhesion and…

Analysis of PDEs · Mathematics 2024-10-18 Maria Eckardt , Anna Zhigun

In this paper we analyze a new temperature-dependent model for adhesive contact that encompasses nonlocal adhesive forces and damage effects, as well as nonlocal heat flux contributions on the contact surface. The related PDE system…

Analysis of PDEs · Mathematics 2021-04-13 Giovanna Bonfanti , Michele Colturato , Riccarda Rossi

We provide a review of recent advancements in nonlocal continuous models for migration, mainly from the perspective of its involvement in embryonal development and cancer invasion. Particular emphasis is placed on spatial nonlocality…

Analysis of PDEs · Mathematics 2019-11-14 Li Chen , Kevin Painter , Christina Surulescu , Anna Zhigun

A thermodynamically consistent phase-field model is introduced for simulating multicellular deformation, and aggregation under flow conditions. In particular, a Lennard-Jones type potential is proposed under the phase-field framework for…

Numerical Analysis · Mathematics 2022-05-17 Lingyue Shen , Ping Lin , Zhiliang Xu , Shixin Xu

In this paper, we propose two approaches to apply boundary conditions for bond-based peridynamic models. There has been in recent years a renewed interest in the class of so-called non-local models, which include peridynamic models, for the…

Computational Engineering, Finance, and Science · Computer Science 2020-10-02 Serge Prudhomme , Patrick Diehl

In this paper we examine boundary effects in a fractional chemotactic equation derived from a kinetic transport model describing cell movement in response to chemical gradients (chemotaxis). Specifically, we analyze reflecting boundary…

Analysis of PDEs · Mathematics 2025-06-05 Gissell Estrada-Rodriguez , Heiko Gimperlein

The purpose of this work is to propose a non-Markovian and nonlinear model of subdiffusive transport that involves adhesion affects the cells escape rates form position x, with chemotaxis. This leads the escape rates to be dependent on the…

Cell Behavior · Quantitative Biology 2016-03-02 Akram Al-Sabbagh
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