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Cell-cell adhesion is widely hypothesised to maintain cohesion within the long streams of follower cells that trail leader subpopulations during collective migration, including in neural crest cell migration, angiogenesis, and cancer cell…

Cell Behavior · Quantitative Biology 2026-04-17 Thomas Jun Jewell , Samuel W. S. Johnson , Ruth E. Baker , Philip K. Maini

Macromolecules can form regular structures on inert surfaces. We have developed a combined empirical and modeling approach to derive the bonding. From experimental scanning tunneling microscopy (STM) images of structures formed on Au(111)…

We consider a parabolic non-local free boundary problem that has been derived as a limit of a bulk-surface reaction-diffusion system which models cell polarization. The authors have justified the well-posedness of this problem and have…

Analysis of PDEs · Mathematics 2023-04-24 Anna Logioti , Barbara Niethammer , Matthias Röger , Juan J. L. Velázquez

Aim of the paper is to study non-local dynamic boundary conditions of reactive-diffusive type for the Laplace equation from analytic and probabilistic point of view. In particular, we provide compact and probabilistic representation of the…

Probability · Mathematics 2024-12-09 Raffaela Capitanelli , Mirko D'Ovidio

We consider a class of nonlocal Cahn-Hilliard equations in a bounded domain $\Omega\subset\mathbb{R}^{d}$ $(d\in\{2,3\})$, subject to a nonlocal kinetic rate dependent dynamic boundary condition. This diffuse interface model describes phase…

Analysis of PDEs · Mathematics 2024-12-11 Maoyin Lv , Hao Wu

We present a single, unified, multi-scale model to study the attachment\detachment dynamics of two deforming, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous fluid medium. The…

Cell Behavior · Quantitative Biology 2015-04-23 Sarthok Sircar , Anthony J. Roberts

We consider the behavior of the nonlocal minimal surfaces in the vicinity of the boundary. By a series of detailed examples, we show that nonlocal minimal surfaces may stick at the boundary of the domain, even when the domain is smooth and…

Analysis of PDEs · Mathematics 2016-03-17 Serena Dipierro , Ovidiu Savin , Enrico Valdinoci

We consider a nonlocal nonlinear model with fractional diffusion motivated by studies of electroconvection phenomena in incompressible viscous fluids. We address the global well-posedness, global regularity and long time dynamics of the…

Analysis of PDEs · Mathematics 2023-10-02 E. Abdo , M. Ignatova

We study the global well-posedness and asymptotic behavior for a semilinear damped wave equation with Neumann boundary conditions, modelling a one-dimensional linearly elastic body interacting with a rigid substrate through an adhesive…

Starting from a mesoscopic description of cell migration and intraspecific interactions we obtain by upscaling an effective reaction-difusion-taxis equation for the cell population density involving spatial nonlocalities in the source term…

Analysis of PDEs · Mathematics 2023-07-31 Maria Eckardt , Christina Surulescu

Based on the development in dealing with nonlocal boundary conditions, we propose a seamless local-nonlocal coupling diffusion model in this paper. In our model, a finite constant interaction horizon is equipped in the nonlocal part and…

Analysis of PDEs · Mathematics 2025-06-24 Yanzun Meng , Zuoqiang Shi

In this paper we consider and generalize a model, recently proposed and analytically investigated in its quasi-stationary approximation by the authors, for visco-elasticity with large deformations and conditional compatibility, where the…

Analysis of PDEs · Mathematics 2024-03-14 Abramo Agosti , Michel Fremond

Realistic examples of reaction-diffusion phenomena governing spatial and spatiotemporal pattern formation are rarely isolated systems, either chemically or thermodynamically. However, even formulations of `open' reaction-diffusion systems…

Pattern Formation and Solitons · Physics 2021-05-14 Andrew L. Krause , Václav Klika , Philip K. Maini , Denis Headon , Eamonn A. Gaffney

The celebrated experiment of Tuval et al. \cite{tuval2005bacterial} showed that the bacteria living a water drop can form a thin layer near the air-water interface, where a so-called chemotaxis-fluid system with physical boundary conditions…

Analysis of PDEs · Mathematics 2024-12-07 Jose Antonio Carrillo , Guangyi Hong , Zhi-an Wang

Lipid bilayer membranes are commonly modeled as area-preserving fluid surfaces that resist bending. There appear to be two schools of thought in the literature concerning the actual area constraint. In some works the total or global area…

Biological Physics · Physics 2015-06-23 Sanjay Dharmavaram , Timothy J. Healey

Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during…

Soft Condensed Matter · Physics 2009-06-10 Thomas R. Weikl , Mesfin Asfaw , Heinrich Krobath , Bartosz Rozycki , Reinhard Lipowsky

Many biological examples of fluid-structure interaction, including the transit of red blood cells through the narrow slits in the spleen and the intracellular trafficking of vesicles into dendritic spines, involve the near-contact of…

Numerical Analysis · Mathematics 2017-12-20 Thomas G. Fai , Chris H. Rycroft

Adhesion bonds between membranes and surfaces are attracted to each other via effective interactions whose origin the entropy loss due to the reduction in the amplitude of the membrane thermal fluctuations in the vicinity of the adhesion…

Soft Condensed Matter · Physics 2015-05-30 Noam Weil , Oded Farago

In this paper we establish existence, uniqueness, and boundedness results for an elliptic variational inequality coupled with a nonlinear ordinary differential equation. Under the general framework, we present a new application modelling…

Analysis of PDEs · Mathematics 2024-06-18 Nadia Skoglund Taki

Existing nonlocal diffusion models are predominantly classified into two categories: bond-based models, which involve a single-fold integral and usually simulate isotropic diffusion, and state-based models, which contain a double-fold…

Numerical Analysis · Mathematics 2024-01-11 Lili Ju , Hao Tian , Junke Lu