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We develop and analyse a discrete, one-dimensional model of cell motility which incorporates the effects of volume filling, cell-to-cell adhesion and chemotaxis. The formal continuum limit of the model is a nonlinear generalisation of the…

Analysis of PDEs · Mathematics 2011-01-14 K. Anguige

We consider an adhesive contact between a thin soft layer on a rigid substrate and a rigid cylindrical indenter ("line contact") with account of the surface tension of the layer. First, it is shown that the boundary condition for the…

Soft Condensed Matter · Physics 2020-02-06 Valentin L. Popov

In this paper we consider 2D nonlocal diffusion models with a finite nonlocal horizon parameter $\delta$ characterizing the range of nonlocal interactions, and consider the treatment of Neumann-like boundary conditions that have proven…

Analysis of PDEs · Mathematics 2019-08-13 Huaiqian You , Xin Yang Lu , Nathaniel Trask , Yue Yu

The nonlocal models of peridynamics have successfully predicted fractures and deformations for a variety of materials. In contrast to local mechanics, peridynamic boundary conditions must be defined on a finite volume region outside the…

Analysis of PDEs · Mathematics 2021-06-29 Mikil Foss , Petronela Radu , Yue Yu

This paper presents some sufficient conditions for the existence of solutions of fractional differential equation with nonlocal multi-point boundary conditions involving Caputo fractional derivative and integral boundary conditions. Our…

Classical Analysis and ODEs · Mathematics 2018-11-28 Faouzi Haddouchi

When a fluid surface adheres to a substrate, the location of the contact line adjusts in order to minimize the overall energy. This adhesion balance implies boundary conditions which depend on the characteristic surface deformation…

Soft Condensed Matter · Physics 2011-11-09 Markus Deserno , Martin M. Mueller , Jemal Guven

We generalize the one-dimensional population model of Anguige \& Schmeiser [1] reflecting the cell-to-cell adhesion and volume filling and classify the resulting equation into the six types. Among these types, we fix one that yields a class…

Analysis of PDEs · Mathematics 2025-08-20 Hyung Jun Choi , Seonghak Kim , Youngwoo Koh

This article deals with a class of chemotaxis systems describing mechanisms from mathematical biology. In the specific, for a rather general class of attraction-repulsion models, with nonlinear productions, diffusion, sensitivities and…

Analysis of PDEs · Mathematics 2023-11-14 Alessandro Columbu , Rafael Diaz Fuentes , Silvia Frassu

We provide a rigorous mathematical framework to establish the limit of a nonlocal model of cell-cell adhesion system to a local model. When the parameter of the nonlocality goes to 0, the system tends to a Cahn-Hilliard system with…

Analysis of PDEs · Mathematics 2023-03-22 José A. Carrillo , Charles Elbar , Jakub Skrzeczkowski

We introduce two different ways of coupling local and nonlocal equations with Neumann boundary conditions in such a way that the resulting model is naturally associated with an energy functional. For these two models we prove that there is…

Analysis of PDEs · Mathematics 2021-12-02 Gabriel Acosta , Francisco Bersetche , Julio Rossi

A rigorous limit procedure is presented which links nonlocal models involving adhesion or nonlocal chemotaxis to their local counterparts featuring haptotaxis and classical chemotaxis, respectively. It relies on a novel reformulation of the…

Analysis of PDEs · Mathematics 2019-11-27 Maria Krasnianski , Kevin Painter , Christina Surulescu , Anna Zhigun

The focus of this work is on the construction of a family of nonlinear absorbing boundary conditions for the Westervelt equation in one and two space dimensions. The principal ingredient used in the design of such conditions is…

Numerical Analysis · Mathematics 2014-08-22 Barbara Kaltenbacher , Igor Shevchenko

We investigate micro-to-macroscopic derivations in two models of living cells, in presence to cell-cell adhesive interactions. We rigorously address two PDE-based models, one featuring non-local terms and another purely local, as a a result…

Probability · Mathematics 2016-01-21 Mikhail Neklyudov , Dario Trevisan

The development of traction-force microscopy, in the past two decades, has created the unprecedented opportunity of performing direct mechanical measurements on living cells as they adhere or crawl on uniform or micro-patterned substrates.…

Biological Physics · Physics 2019-10-25 Luca Giomi

For some spatially nonlocal diffusion models with a finite range of nonlocal interactions measured by a positive parameter $\delta$, we review their formulation defined on a bounded domain subject to various conditions that correspond to…

Analysis of PDEs · Mathematics 2022-12-27 Qiang Du , Xiaochuan Tian , Zhi Zhou

Pattern formation exhibited by a two-dimensional reaction-diffusion system in the fast inhibitor limit is considered from the point of view of interface motion. A dissipative nonlocal equation of motion for the boundary between high and low…

Condensed Matter · Physics 2009-10-22 Dean M. Petrich , Raymond E. Goldstein

In this work, we investigate the dynamics of a non-local model describing spontaneous cell polarisation. It consists in a drift-diffusion equation set in the half-space, with the coupling involving the trace value on the boundary. We…

Analysis of PDEs · Mathematics 2011-05-24 Vincent Calvez , Rhoda Hawkins , Nicolas Meunier , Raphael Voituriez

Motivated by rolling adhesion of white blood cells in the vasculature, we study how cells move in linear shear flow above a wall to which they can adhere via specific receptor-ligand bonds. Our computer simulations are based on a Langevin…

Cell Behavior · Quantitative Biology 2008-04-30 C. B. Korn , U. S. Schwarz

Adhesive contact between a thin elastic sheet and a substrate in a liquid environment arises in a range of biological, physical and technological applications. By considering the dynamics of this process that naturally couples fluid flow,…

Fluid Dynamics · Physics 2015-08-26 Andreas Carlson , Shreyas Mandre , L. Mahadevan

We investigate the long term behavior in terms of finite dimensional global and exponential attractors, as time goes to infinity, of solutions to a semilinear reaction-diffusion equation on non-smooth domains subject to nonlocal Robin…

Dynamical Systems · Mathematics 2016-07-20 Ciprian G. Gal , Mahamadi Warma