Related papers: Interpretable Deep Learning in Drug Discovery

Neural networks are widely regarded as black-box models, creating significant challenges in understanding their inner workings, especially in natural language processing (NLP) applications. To address this opacity, model explanation…

Because of the pervasive usage of Neural Networks in human sensitive applications, their interpretability is becoming an increasingly important topic in machine learning. In this work we introduce a simple way to interpret the output…

Most deep learning recommendation models operate as black boxes, relying on latent representations that obscure their decision process. This lack of intrinsic interpretability raises concerns in applications that require transparency and…

A variety of methods have been proposed for interpreting nodes in deep neural networks, which typically involve scoring nodes at lower layers with respect to their effects on the output of higher-layer nodes (where lower and higher layers…

Deep learning is currently playing a crucial role toward higher levels of artificial intelligence. This paradigm allows neural networks to learn complex and abstract representations, that are progressively obtained by combining simpler…

Understanding how information is represented in neural networks is a fundamental challenge in both neuroscience and artificial intelligence. Despite their nonlinear architectures, recent evidence suggests that neural networks encode…

With the availability of large databases and recent improvements in deep learning methodology, the performance of AI systems is reaching or even exceeding the human level on an increasing number of complex tasks. Impressive examples of this…

We propose a general framework called Network Dissection for quantifying the interpretability of latent representations of CNNs by evaluating the alignment between individual hidden units and a set of semantic concepts. Given any CNN model,…

Algorithms are powerful and necessary tools behind a large part of the information we use every day. However, they may introduce new sources of bias, discrimination and other unfair practices that affect people who are unaware of it.…

Graph Neural Networks have been widely applied in critical decision-making areas that demand interpretable predictions, leading to the flourishing development of interpretability algorithms. However, current graph interpretability…

End-to-end deep neural networks have achieved remarkable success across various domains but are often criticized for their lack of interpretability. While post hoc explanation methods attempt to address this issue, they often fail to…

In healthcare there is a pursuit for employing interpretable algorithms to assist healthcare professionals in several decision scenarios. Following the Predictive, Descriptive and Relevant (PDR) framework, the definition of interpretable…

This article presents the prediction difference analysis method for visualizing the response of a deep neural network to a specific input. When classifying images, the method highlights areas in a given input image that provide evidence for…

Knowledge extraction is used to convert neural networks into symbolic descriptions with the objective of producing more comprehensible learning models. The central challenge is to find an explanation which is more comprehensible than the…

As interpretability has been pointed out as the obstacle to the adoption of Deep Neural Networks (DNNs), there is an increasing interest in solving a transparency issue to guarantee the impressive performance. In this paper, we demonstrate…

We describe a procedure for explaining neurons in deep representations by identifying compositional logical concepts that closely approximate neuron behavior. Compared to prior work that uses atomic labels as explanations, analyzing neurons…

Neural networks (NNs) have been successfully applied to solve a variety of application problems involving classification and function approximation. Although backpropagation NNs generally predict better than decision trees do for pattern…

Despite their success and widespread adoption, the opaque nature of deep neural networks (DNNs) continues to hinder trust, especially in critical applications. Current interpretability solutions often yield inconsistent or oversimplified…

Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

Despite their great success in recent years, deep neural networks (DNN) are mainly black boxes where the results obtained by running through the network are difficult to understand and interpret. Compared to e.g. decision trees or bayesian…