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Related papers: Interpretable Deep Learning in Drug Discovery

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To plan safe maneuvers and act with foresight, autonomous vehicles must be capable of accurately predicting the uncertain future. In the context of autonomous driving, deep neural networks have been successfully applied to learning…

Robotics · Computer Science 2022-08-02 Salar Arbabi , Davide Tavernini , Saber Fallah , Richard Bowden

The thesis explores the role machine learning methods play in creating intuitive computational models of neural processing. Combined with interpretability techniques, machine learning could replace human modeler and shift the focus of human…

Neurons and Cognition · Quantitative Biology 2020-10-20 Ilya Kuzovkin

Advances in machine learning have led to graph neural network-based methods for drug discovery, yielding promising results in molecular design, chemical synthesis planning, and molecular property prediction. However, current graph neural…

Quantitative Methods · Quantitative Biology 2021-07-13 Jiahua Rao , Shuangjia Zheng , Yuedong Yang

While deep neural networks (DNN) have become an effective computational tool, the prediction results are often criticized by the lack of interpretability, which is essential in many real-world applications such as health informatics.…

Computer Vision and Pattern Recognition · Computer Science 2018-05-29 Mengnan Du , Ninghao Liu , Qingquan Song , Xia Hu

Deep neural networks (DNNs) have shown exceptional performances in a wide range of tasks and have become the go-to method for problems requiring high-level predictive power. There has been extensive research on how DNNs arrive at their…

Machine Learning · Computer Science 2023-02-21 Mattias Luber , Anton Thielmann , Benjamin Säfken

Understanding the predictions made by deep learning models remains a central challenge, especially in high-stakes applications. A promising approach is to equip models with the ability to answer counterfactual questions -- hypothetical…

Machine Learning · Computer Science 2025-10-28 Inwoo Hwang , Yushu Pan , Elias Bareinboim

The ability to interpret machine learning model decisions is critical in such domains as healthcare, where trust in model predictions is as important as their accuracy. Inspired by the development of prototype parts-based deep neural…

Machine Learning · Computer Science 2026-03-06 Jacek Karolczak , Jerzy Stefanowski

The current understanding of deep neural networks can only partially explain how input structure, network parameters and optimization algorithms jointly contribute to achieve the strong generalization power that is typically observed in…

Machine Learning · Computer Science 2021-01-28 Francesco Craighero , Fabrizio Angaroni , Alex Graudenzi , Fabio Stella , Marco Antoniotti

Not only are Deep Neural Networks (DNNs) black box models, but also we frequently conceptualize them as such. We lack good interpretations of the mechanisms linking inputs to outputs. Therefore, we find it difficult to analyze in…

Machine Learning · Computer Science 2020-06-29 Christopher Snyder , Sriram Vishwanath

Interpreting the inner workings of deep learning models is crucial for establishing trust and ensuring model safety. Concept-based explanations have emerged as a superior approach that is more interpretable than feature attribution…

Machine Learning · Computer Science 2023-07-17 Mara Graziani , Laura O' Mahony , An-Phi Nguyen , Henning Müller , Vincent Andrearczyk

Still under debate is the question of whether machine learning is capable of going beyond black-box modeling for complex physical systems. We investigate the generalizing and interpretability properties of learning algorithms. To this end,…

Statistical Mechanics · Physics 2019-02-18 C. Casert , T. Vieijra , J. Nys , J. Ryckebusch

During the last decade, deep neural networks (DNN) have demonstrated impressive performances solving a wide range of problems in various domains such as medicine, finance, law, etc. Despite their great performances, they have long been…

Machine Learning · Computer Science 2020-10-13 Jiechieu Kameni Florentin Flambeau , Tsopze Norbert

With the advent of highly predictive but opaque deep learning models, it has become more important than ever to understand and explain the predictions of such models. Existing approaches define interpretability as the inverse of complexity…

Graph Neural Networks (GNNs) have shown great ability in modeling graph-structured data for various domains. However, GNNs are known as black-box models that lack interpretability. Without understanding their inner working, we cannot fully…

Machine Learning · Computer Science 2022-10-06 Enyan Dai , Suhang Wang

Providing explanations for deep neural networks (DNNs) is essential for their use in domains wherein the interpretability of decisions is a critical prerequisite. Despite the plethora of work on interpreting DNNs, most existing solutions…

Machine Learning · Computer Science 2021-01-26 Xinyang Zhang , Ren Pang , Shouling Ji , Fenglong Ma , Ting Wang

Interpretability of Deep Neural Networks has become a major area of exploration. Although these networks have achieved state of the art accuracy in many tasks, it is extremely difficult to interpret and explain their decisions. In this work…

Computer Vision and Pattern Recognition · Computer Science 2022-04-05 Akshay Badola , Cherian Roy , Vineet Padmanabhan , Rajendra Lal

Despite substantial efforts, neural network interpretability remains an elusive goal, with previous research failing to provide succinct explanations of most single neurons' impact on the network output. This limitation is due to the…

Machine Learning · Computer Science 2024-02-01 Simon C. Marshall , Jan H. Kirchner

In the context of classification problems, Deep Learning (DL) approaches represent state of art. Many DL approaches are based on variations of standard multi-layer feed-forward neural networks. These are also referred to as deep networks.…

Machine Learning · Computer Science 2023-11-21 Andrea Apicella , Francesco Isgrò , Roberto Prevete

Foundation models are powerful yet often opaque in their decision-making. A topic of continued interest in both neuroscience and artificial intelligence is whether some neurons behave like grandmother cells, i.e., neurons that are…

Machine Learning · Computer Science 2026-01-08 Ricardo Knauer , Erik Rodner

Deep neural networks are effective feature extractors but they are prohibitively large for deployment scenarios. Due to the huge number of parameters, interpretability of parameters in different layers is not straight-forward. This is why…

Computation and Language · Computer Science 2021-12-23 Saeed Damadi