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Null Hypothesis Significance Testing (NHST) has long been central to the scientific project, guiding theory development and supporting evidence-based intervention and decision-making. Recent years, however, have seen growing awareness of…

Methodology · Statistics 2020-10-16 Fintan Costello , Paul Watts

$P$-values that are derived from continuously distributed test statistics are typically uniformly distributed on $(0,1)$ under least favorable parameter configurations (LFCs) in the null hypothesis. Conservativeness of a $p$-value $P$…

Methodology · Statistics 2023-03-13 Daniel Ochieng , Anh-Tuan Hoang , Thorsten Dickhaus

\citet{Rosenbaum83ps} introduced the notion of the propensity score and discussed its central role in causal inference with observational studies. Their paper, however, caused a fundamental incoherence with an early paper by…

Methodology · Statistics 2022-03-29 Peng Ding , Tianyu Guo

Many genomic experiments, notably microarray experiments seeking to detect differential gene expression, involve calculating a large number of p-values. This leads to the multiple testing problem: when the number of null hypotheses is…

Quantitative Methods · Quantitative Biology 2007-05-23 David R. Bickel

p-hacking occurs when researchers conduct multiple significance tests (e.g., p1;H0,1 and p2;H0,2) and then selectively report tests that yield desirable (usually significant) results (e.g., p2 < 0.05;H0,2) without correcting for multiple…

Other Statistics · Statistics 2026-05-22 Mark Rubin

We describe a modified sequential probability ratio test that can be used to reduce the average sample size required to perform statistical hypothesis tests at specified levels of significance and power. Examples are provided for $z$ tests,…

Methodology · Statistics 2020-12-04 Sandipan Pramanik , Valen E. Johnson , Anirban Bhattacharya

It is possible to obtain a large Bayes Factor (BF) favoring the null hypothesis when both the null and alternative hypotheses have low likelihoods, and there are other hypotheses being ignored that are much more strongly supported by the…

Methodology · Statistics 2019-07-15 Michael Smithson

While Null Hypothesis Significance Testing (NHST) remains a widely used statistical tool, it suffers from several shortcomings in its common usage, such as conflating statistical and practical significance, the formulation of inappropriate…

The asymptotically optimal hypothesis testing problem with the general sources as the null and alternative hypotheses is studied under exponential-type error constraints on the first kind of error probability. Our fundamental philosophy in…

Probability · Mathematics 2007-05-23 Te Sun Han

Sequential estimation of a probability $p$ by means of inverse binomial sampling is considered. For $\mu_1,\mu_2>1$ given, the accuracy of an estimator $\hat{p}$ is measured by the confidence level $P[p/\mu_2\leq\hat{p}\leq p\mu_1]$. The…

Statistics Theory · Mathematics 2010-10-12 Luis Mendo , José M. Hernando

Is it possible for a large sequence of measurements or observations, which support a hypothesis, to counterintuitively decrease our confidence? Can unanimous support be too good to be true? The assumption of independence is often made in…

These notes survey and explore an emerging method, which we call the low-degree method, for predicting and understanding statistical-versus-computational tradeoffs in high-dimensional inference problems. In short, the method posits that a…

Statistics Theory · Mathematics 2019-07-29 Dmitriy Kunisky , Alexander S. Wein , Afonso S. Bandeira

The null hypothesis test (NHT) is widely used for validating scientific hypotheses but is actually highly criticized. Although Bayesian tests overcome several criticisms, some limits remain. We propose a Bayesian two-interval test (2IT) in…

Methodology · Statistics 2021-07-06 Nicolas Meyer , Erik-André Sauleau

P-values are a mainstay in statistics but are often misinterpreted. We propose a new interpretation of p-value as a meaningful plausibility, where this is to be interpreted formally within the inferential model framework. We show that, for…

Statistics Theory · Mathematics 2014-10-28 Ryan Martin , Chuanhai Liu

In a recent simulation study, Goodman et al. (2019) compare several methods with regard to their type I and type II error rates in case of a thick null hypothesis that includes all values that are practically equivalent to the point null…

Methodology · Statistics 2022-06-07 Robin Tim Dreher , Leona Hoffmann , Arne Kramer-Sunderbrink , Peter Pütz , Robin Werner

In traditional hypothesis testing one must pre-specify the significance level $\alpha$ to bound the `size' of the test: its probability to falsely reject the hypothesis. Indeed, a data-dependent selection of $\alpha$ would generally distort…

Statistics Theory · Mathematics 2025-12-03 Nick W. Koning

In this paper, we develop invariance-based procedures for testing and inference in high-dimensional regression models. These procedures, also known as randomization tests, provide several important advantages. First, for the global null…

Methodology · Statistics 2023-12-27 Wenxuan Guo , Panos Toulis

When are inferences (whether Direct-Likelihood, Bayesian, or Frequentist) obtained from partial data valid? This paper answers this question by offering a new asymptotic theory about inference with missing data that is more general than…

Statistics Theory · Mathematics 2022-08-09 Julian Morimoto

The main purpose of this paper is to introduce first a new family of empirical test statistics for testing a simple null hypothesis when the vector of parameters of interest are defined through a specific set of unbiased estimating…

Statistics Theory · Mathematics 2014-08-19 Narayanaswamy Balakrishnan , Nirian Martín , Leandro Pardo

A new formulation for the proportion of true null hypotheses $(\pi_0)$, based on the sum of all $p$-values and the average of expected $p$-value under the false null hypotheses has been proposed in the current work. This formulation of the…

Statistics Theory · Mathematics 2020-04-07 Aniket Biswas