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Purpose of Review Imaging derived fractional flow reserve (FFR) is rapidly evolving beyond conventional computational fluid dynamics (CFD) based pipelines toward machine learning (ML), deep learning (DL), and physics informed approaches…

Medical Physics · Physics 2026-04-08 Tanxin Zhu , Emran Hossen , Chen Zhao , Jingfeng Jiang , Michele Esposito , Jiguang Sun , Weihua Zhou

Deformation modeling of cardiac muscle is an important issue in the field of cardiac analysis. Many approaches have been developed to better estimate the cardiac muscle deformation, and to obtain a practical model to be used in diagnostic…

Computational Engineering, Finance, and Science · Computer Science 2015-12-01 Ahmadreza Baghaie , Hamid Abrishami Moghaddam

The development and progression of abdominal aortic aneurysms (AAA) are related to complex flow patterns and wall-shear-driven mechanobiological stimuli, yet the quantitative relationship between aneurysmal geometry and hemodynamics remains…

We present the meshfree Mixed Collocation Method (MCM) to solve the monodomain model for numerical simulation of cardiac electrophysiology. We apply MCM to simulate cardiac electrical propagation in 2D tissue sheets and 3D tissue slabs as…

Numerical Analysis · Mathematics 2021-10-14 Konstantinos A. Mountris , Esther Pueyo

The numerical treatment of fluid-particle systems is a very challenging problem because of the complex coupling phenomena occurring between the two phases. Although accurate mathematical modelling is available to address this kind of…

Numerical Analysis · Mathematics 2024-03-22 Arash Hajisharifi , Rahul Halder , Michele Girfoglio , Andrea Beccari , Domenico Bonanni , Gianluigi Rozza

The limitations of conventional imaging techniques have hitherto precluded a thorough and formal investigation of the complex morphology of the left ventricular (LV) endocardial surface and its relation to the severity of Coronary Artery…

Computer Vision and Pattern Recognition · Computer Science 2013-02-14 Anirban Mukhopadhyay , Zhen Qian , Suchendra M. Bhandarkar , Tianming Liu , Sarah Rinehart , Szilard Voros

We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion…

Over the past decade, several studies have explored the potential of magnetic resonance fingerprinting (MRF) for the quantification of brain hemodynamics, oxygenation, and perfusion. Recent advances in simulation models and reconstruction…

Signal Processing · Electrical Eng. & Systems 2025-12-16 T. Coudert , A. Delphin , A. Barrier , E L Barbier , B. Lemasson , J M Warnking , T. Christen

Left ventricular ejection fraction (LVEF) is a key indicator of cardiac function and plays a central role in the diagnosis and management of cardiovascular disease. Echocardiography, as a readily accessible and non-invasive imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Shravan Saranyan , Pramit Saha

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…

Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made subject-specific modelling of the cardiovascular system a…

Quantitative Methods · Quantitative Biology 2021-01-18 Mitchel J. Colebank , L. Mihaela Paun , M. Umar Qureshi , Naomi Chesler , Dirk Husmeier , Mette S. Olufsen , Laura Ellwein Fix

This paper introduces an inviscid Computational Fluid Dynamics (CFD) approach for the rapid aerodynamic assessment of Flettner rotor systems on ships. The method relies on the Eulerian flow equations, approximated utilizing a…

Fluid Dynamics · Physics 2025-05-09 Niklas Kühl

In the United States, heart disease is the leading cause of death for both men and women, accounting for 610,000 deaths each year [1]. Physicians use Magnetic Resonance Imaging (MRI) scans to take images of the heart in order to…

Computer Vision and Pattern Recognition · Computer Science 2018-11-22 Ehab Abdelmaguid , Jolene Huang , Sanjay Kenchareddy , Disha Singla , Laura Wilke , Mai H. Nguyen , Ilkay Altintas

Low left ventricular ejection fraction (LEF) frequently remains undetected until progression to symptomatic heart failure, underscoring the need for scalable screening strategies. Although artificial intelligence-enabled electrocardiography…

Machine Learning · Computer Science 2026-04-07 Ya Zhou , Tianxiang Hao , Ziyi Cai , Haojie Zhu , Kejun He , Jia Liu , Xiaohan Fan , Jing Yuan

Prediction of the blood flow characteristics is of utmost importance for understanding the behavior of the blood arterial network, especially in the presence of vascular diseases such as stenosis. Computational fluid dynamics (CFD) has…

Machine Learning · Computer Science 2021-11-11 Mohammad Farajtabar , Mohit Biglarian , Morteza Miansari

Accurate and rapid estimation of hemodynamic metrics, such as pressure and wall shear stress (WSS), is important for assessing the severity of Coronary Artery Disease (CAD). Existing approaches, including invasive Fractional Flow Reserve…

Computational Engineering, Finance, and Science · Computer Science 2026-05-28 Reza Akbarian Bafghi , Sukirt Thakur , Maziar Raissi

A CFD-driven deterministic symbolic identification algorithm for learning explicit algebraic Reynolds-stress models (EARSM) from high-fidelity data is developed building on the frozen-training SpaRTA algorithm of [1]. Corrections for the…

Fluid Dynamics · Physics 2022-03-14 I. Ben Hassan SaÏdi , M. Schmelzer , P. Cinnella , F. Grasso

Background: How can mathematics help us to understand the mechanism of the cardiac motion? The best known approach is to take a mathematical model of the fibered structure, insert it into a more-or-less complex model of cardiac…

Medical Physics · Physics 2014-06-25 Saeed Ranjbar , Mersedeh Karvandi

Thoracic endovascular aortic repair (TEVAR) has developed to be the most effective treatment for aortic diseases. This study aims to evaluate the biomechanical implications of the implanted endograft after TEVAR. We present a novel…

Medical Physics · Physics 2022-01-13 Yonghui Qiao , Le Mao , Ying Ding , Ting Zhu , Kun Luo , Jianren Fan

We propose an integrated electromechanical model of the human heart, with focus on the left ventricle, wherein biophysically detailed models describe the different physical phenomena concurring to the cardiac function. We model the…