Related papers: Moonshots for aging
Human space exploration beyond low Earth orbit will involve missions of significant distance and duration. To effectively mitigate myriad space health hazards, paradigm shifts in data and space health systems are necessary to enable…
More than 30 years have passed since the Voyager 2 fly-bys of Uranus and Neptune. I discuss a range of lessons learned from Voyager, broadly grouped into process, planning, and people. In terms of process, we must be open to new concepts:…
The lunar surface has historically been considered an optimal site for a broad range of astronomical telescopes. That assumption, which has come to be somewhat reflexive, is critically examined in this paper and found to be poorly…
Medical investigations focusing on patient survival often generate not only a failure time for each patient but also a sequence of measurements on patient health at annual or semi-annual check-ups while the patient remains alive. Such a…
Recently, we showed that the possibility of an interstellar mission to the closest black hole, while highly speculative and extremely challenging, is not completely unrealistic within the next few decades. Since such a mission might last…
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to…
Chronic disease is a long-lasting condition that can be controlled but not cured. Owing to the portability and continuous action, wearable devices are regarded as promising ways for management and rehabilitation of patients with chronic…
Melanoma is one of the most dangerous forms of cancer. The five-year survival rate is 98% if it is detected early. However, this rate plummets to 63% for regional disease and 17% when tumors have metastasized, that is, spread to distant…
Aging refers to the property of two-time correlation functions to decay very slowly on (at least) two time scales. This phenomenon has gained recent attention due to experimental observations of the history dependent relaxation behavior in…
Interstellar exploration will advance human knowledge and culture in multiple ways. Scientifically, it will advance our understanding of the interstellar medium, stellar astrophysics, planetary science and astrobiology. In addition,…
Mechanical force is tightly connected to human health status, and the occurrence of disease can generally be ascribed to certain loss of force balance. However, the role of mechanical approaches in tumor therapy is largely neglected, while…
Time and its lack of play a central role in our everyday lives. Despite increasing productivity, many people experience time stress, exhaustion and a longing for time affluence, and at the same time, a fear of not being busy enough. All…
The provision of intergenerational care, via the Grandmother Hypothesis, has been implicated in the evolution of post-fertile longevity, particularly in humans. However, if grandmothering does provide fitness benefits, a key question is why…
We propose a method of estimating the Total Loss of Healthy Life Years based on the first exit time theory for a stochastic process, the resulting Health State Function and the Deterioration Function estimated as the curvature of the health…
Widespread population aging has made it critical to understand death rates at old ages. However, studying mortality at old ages is challenging because the data are sparse: numbers of survivors and deaths get smaller and smaller with age. We…
The risk of a catastrophic or existential disaster for our civilization is increasing this century. A significant motivation for a near-term space settlement is the opportunity to safeguard civilization in the event of a planetary-scale…
The age of an individual star cannot be measured, only estimated through mostly model-dependent or empirical methods, and no single method works well for a broad range of stellar types or for a full range in age. This review presents a…
The lunar poles are unique environments of both great scientific and, increasingly, commercial interest. Consequently, a tension exists between the twin objectives of (a) Exploring the lunar poles for both scientific and commercial purposes…
The world is changing fast, and so is the space sector. Planning for large scientific experiments two decades ahead may no longer be the most sensible approach. I develop the argument that large science experiments are becoming comparable…
The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it…