Related papers: Moonshots for aging
In this paper, we affirm our earlier findings of evidence for a limit to human lifespan. In particular, we assess the analyses in extreme value theory (EVT) performed by Rootz\'en and Zholud. We find that their criticisms of our work are…
Throughout history, for reasons of health, well known personalities have opted not to eat to satiety - to under-eat - with known benefits. Here, for the benefits of under-eating a very simple explanation is offered and discussed in some…
This study attempts to establish a basis for understanding how methods used in research in solar physics have evolved since World War II (WWII). The goal is to begin to explore if and how the changing research environment affects the…
We study the dynamics of an age-structured population in which the life expectancy of an offspring may be mutated with respect to that of its parent. When advantageous mutation is favored, the average fitness of the population grows…
Searching for extraterrestrial life and supporting human life in space are traditionally regarded as separate challenges. However, there are significant benefits to an approach that treats them as different aspects of the same essential…
There is growing interest in the possibility that the resource base of the Solar System might in future be used to supplement the economic resources of our own planet. As the Earth's closest celestial neighbour, the Moon is sure to feature…
Aging is a universal consequence of life, yet researchers have identified no universal theme. This manuscript considers aging from the perspective of entropy, wherein things fall apart. We first examine biological information change as a…
The lunar surface is a compelling location for large, distributed optical facilities, with significant advantages over orbital facilities for high spatial resolution astrophysics. The serious development of mission concepts is timely…
In these lecture notes I describe some of the main theoretical ideas emerged to explain the aging dynamics. This is meant to be a very short introduction to aging dynamics and no previous knowledge is assumed. I will go through simple…
In many cohorts (such as the UK Biobank) on which Mendelian Randomization studies are routinely performed, data on participants' longevity is inadequate as the majority of participants are still living. To nevertheless estimate effects on…
The long-term sustainability of research software is a critical challenge, as it usually suffers from poor maintainability, lack of adaptability, and eventual obsolescence. This paper proposes a novel approach to addressing this issue by…
Motivated by recent research of aging in E. coli, we explore the effects of aging on bacterial fitness. The disposable soma theory of aging was developed to explain how differences in lifespans and aging rates could be linked to life…
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These…
Some human mission trajectories to Mars include flybys of Venus. These flybys provide opportunities to practice deep space human operations, and offer numerous safe-return-to-Earth options, before committing to longer and lower-cadence…
Maintaining physical activity is essential for older adults' health and well-being, yet participation remains low. Traditional paper-based and in-person interventions have been effective but face scalability issues. Smartphone apps offer a…
From the basic impact of nutrient intake on health maintenance to the psychosocial benefits of mealtime, great advancements in nutritional sciences for support of human space travel have occurred over the past 60 years. Nutrition in space…
Well protected human and laboratory animal populations with abundant resources are evolutionary unprecedented. Physical approach, which takes advantage of their extensively quantified mortality, establishes that its dominant fraction yields…
Many science missions require an unobstructed view of space and a stable thermal environment but lack the technical or programmatic resources to reach orbits that satisfy these needs. This paper presents a high Earth orbit in 2:1 resonance…
Two decades ago, astronomers began detecting planets orbiting stars other than our Sun, so-called exoplanets. Since that time, the rate of detections and the sensitivity to ever-smaller planets has improved dramatically with several…
Our view of the microbial world and its impact on human health is changing radically with the ability to sequence uncultured or unculturable microbes sampled directly from their habitats, ability made possible by fast and cheap next…