Open problems in ageing science: A roadmap for biogerontology
Abstract
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorized into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers, and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website (www.longevityknowledge.app). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology.
Keywords
Cite
@article{arxiv.2507.18602,
title = {Open problems in ageing science: A roadmap for biogerontology},
author = {Angelo Talay and Aleksey V. Belikov and Paul Ka Po To and Hamid H. Alfatemi and Uri Alon and Joris Deelen and Collin Y. Ewald and David Gems and Vera Gorbunova and Jan Gruber and Sara Hägg and John Hemming and Steve Horvath and Alaattin Kaya and Caitlin J. Lewis and Andrea Maier and Maria B Marinova and Graham Pawelec and Shahaf Peleg and Suresh Rattan and Morten Scheibye-Knudsen and Tomas Schmauck-Medina and Vardan Saroyan and Andrei Seluanov and Alexandra Stolzing and Emma Teeling and Robert W. Williams and Todd White and Maximilian Unfried and João Pedro de Magalhães},
journal= {arXiv preprint arXiv:2507.18602},
year = {2025}
}