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Stem cells are characterized by their ability to self-renew, as well as to differentiate and give rise to new populations of cells. Stem cell divisions are crucial for generative processes that occur during early development, and later in…
The self-organization of cells into complex tissues relies on a tight coordination of cell behavior. Identifying the cellular processes driving tissue growth is key to understanding the emergence of tissue forms and devising targeted…
A comparison theorem for the isoperimetric profile on the universal cover of surfaces evolving by normalised Ricci flow is proven. For any initial metric, a model comparison is constructed that initially lies below the profile of the…
We consider pattern formation using reaction-diffusion equation on various non-uniformly curved surfaces. We explore how, in general, curvature and, in particular the domain shape would affect the pattern formation in these geometries. As…
Cellular rearrangements, as primary sources of tissue fluidization, facilitate topological transitions during tissue morphogenesis. We study the role of intrinsic cell properties such as cell polarity and cell-cell adhesion in shaping…
The main objective of this study is to understand how geometric hyper-ideal circle patterns can be constructed from given combinatorial angle data. We design a hybrid method consisting of a topological/deformation approach augmented with a…
In random tiling and dimer models we can get various limit shapes which gives the boundaries between different types of phases. The shape fluctuations at these boundaries give rise to universal limit laws, in particular the Airy process. We…
We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective…
In order to study a one-dimensional analogue of the spontaneous curvature model for two-component lipid bilayer membranes we consider planar curves that are made of a material with two phases. Each phase induces a preferred curvature to the…
During development, spatio-temporal patterns ranging from checkerboard to engulfing occur with precise proportions of the respective cell fates. Key developmental regulators are intracellular transcriptional interactions and intercellular…
The surfaces of growing biological tissues, swelling gels, and compressed rubbers do not remain smooth, but frequently exhibit highly localized inward folds. We reveal the morphology of this surface folding in a novel experimental setup,…
We use boundary-integral methods to compute the time-dependent deformation of a drop of dielectric fluid immersed in another dielectric fluid in a uniform electric field E. Steady state theory predicts, when the permittivity ratio, \beta,…
We show that a capillary surface in a solid cone, that is, a surface that has constant mean curvature and the boundary of surface meets the boundary of the cone with a constant angle, is radially graphical if the mean curvature is…
The spread of a particular trait in a cell population often is modelled by an appropriate system of ordinary differential equations describing how the sizes of subpopulations of the cells with the same genome change in time. On the other…
In a previous work arXiv:physics/0611108v2, it was shown that the volume spanned by a molecular system in its conformational space can be effectively bounded by a polyhedral cone, this cone is described by means of a simple combinatorial…
Discrete analogs of extrema of curvature and generalizations of the four-vertex theorem to the case of polygons and polyhedra are suggested and developed. For smooth curves and polygonal lines in the plane, a formula relating the number of…
If a droplet is placed on a substrate with a conical shape it spontaneously starts to spread in the direction of a growing fibre radius. We describe this capillary spreading dynamics by developing a lubrication approximation on a cone and…
Cellular automata generate spatially extended, temporally persistent emergent structures from local update rules. No general method derives the mechanisms of that generation from the rule itself; existing tools reconstruct structure from…
Cells actively regulate their size during the cell cycle to maintain volume homeostasis across generations. While various mathematical models of cell size regulation have been proposed to explain how this is achieved, relating these models…
Growth and folding in one-layered model tissue sheets are studied in a stochastic, lattice-free single cell model which considers the discrete cellular structure of the tissue, and a coarse grained analytical approach. The polarity of the…