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This article characterizes certain small multistationary chemical reaction networks. We consider the set of fully open networks, those for which all chemical species participate in inflow and outflow, containing one non-flow (reversible or…

Dynamical Systems · Mathematics 2013-01-18 Badal Joshi

It has been argued by Thom and Palm that sparsely-connected neural networks (SCNs) show improved performance over fully-connected networks (FCNs). Super-regular networks (SRNs) are neural networks composed of a set of stacked sparse layers…

Machine Learning · Computer Science 2022-01-06 Andrew W. E. McDonald , Ali Shokoufandeh

Circuits of biological neurons, such as in the functional parts of the brain can be modeled as networks of coupled oscillators. Inspired by the ability of these systems to express a rich set of outputs while keeping (gradients of) state…

Machine Learning · Computer Science 2021-03-16 T. Konstantin Rusch , Siddhartha Mishra

In self-organized criticality (SOC) models, as well as in standard phase transitions, criticality is only present for vanishing external fields $h \to 0$. Considering that this is rarely the case for natural systems, such a restriction…

Adaptation and Self-Organizing Systems · Physics 2022-02-14 Gustavo Menesse , Bóris Marin , Mauricio Girardi-Schappo , Osame Kinouchi

Neural network controllers have become popular in control tasks thanks to their flexibility and expressivity. Stability is a crucial property for safety-critical dynamical systems, while stabilization of partially observed systems, in many…

Systems and Control · Electrical Eng. & Systems 2021-12-08 Fangda Gu , He Yin , Laurent El Ghaoui , Murat Arcak , Peter Seiler , Ming Jin

Continuous-time Markov chains are frequently used as stochastic models for chemical reaction networks, especially in the growing field of systems biology. A fundamental problem for these Stochastic Chemical Reaction Networks (SCRNs) is to…

Probability · Mathematics 2023-04-12 Felipe A. Campos , Simone Bruno , Yi Fu , Domitilla Del Vecchio , Ruth J. Williams

We present a systematic mathematical analysis of the qualitative steady-state response to rate perturbations in large classes of reaction networks. This includes multimolecular reactions and allows for catalysis, enzymatic reactions,…

Dynamical Systems · Mathematics 2017-11-22 Bernhard Brehm , Bernold Fiedler

Reaction-diffusion equations coupled to ordinary differential equations (ODEs) may exhibit spatially low-regular stationary solutions. This work provides a comprehensive theory of asymptotic stability of bounded, discontinuous or…

Analysis of PDEs · Mathematics 2023-05-18 Chris Kowall , Anna Marciniak-Czochra , Finn Münnich

We propose a direct optimization framework for learning reduced and sparse chemical reaction networks (CRNs) from time-series trajectory data. In contrast to widely used indirect methods-such as those based on sparse identification of…

Molecular Networks · Quantitative Biology 2025-08-27 Maurice Filo , Mustafa Khammash

Chemical reaction networks (CRNs) exhibit complex dynamics governed by their underlying network structure. In this paper, we propose a novel approach to study the dynamics of CRNs by representing them on species graphs (S-graphs). By…

Molecular Networks · Quantitative Biology 2024-04-24 Keisuke Sugie , Dimitri Loutchko , Tetsuya J. Kobayashi

Reaction networks have been widely used as generic models in diverse areas of applied sciences, such as biology, chemistry, ecology, epidemiology, and computer science. A reaction network incorporating noisy effects is modeled as a…

Molecular Networks · Quantitative Biology 2026-05-12 Chuang Xu

A major challenge in structured prediction is to represent the interdependencies within output structures. When outputs are structured as sequences, linear-chain conditional random fields (CRFs) are a widely used model class which can learn…

Machine Learning · Computer Science 2023-08-14 Sean Papay , Roman Klinger , Sebastian Padó

Relu Fully Connected Networks are ubiquitous but uninterpretable because they fit piecewise linear functions emerging from multi-layered structures and complex interactions of model weights. This paper takes a novel approach to piecewise…

Machine Learning · Computer Science 2021-11-23 Jasdeep Singh Grover , Harsh Minesh Domadia , Raj Anant Tapase , Grishma Sharma

Which reaction networks, when taken with mass-action kinetics, have the capacity for multiple steady states? There is no complete answer to this question, but over the last 40 years various criteria have been developed that can answer this…

Dynamical Systems · Mathematics 2015-08-21 Badal Joshi , Anne Shiu

Stochastic reaction networks are mathematical models with a wide range of applications in biochemistry, ecology, and epidemiology, and are often complex to analyze. Except for some special cases, it is generally difficult to predict how the…

Probability · Mathematics 2026-04-02 Daniele Cappelletti , Giulio Cuniberti , Paola Siri

This paper is concerned with programming adaptive linear neural networks (ALNNs) using chemical reaction networks (CRNs) equipped with mass-action kinetics. Through individually programming the forward propagation and the backpropagation of…

Dynamical Systems · Mathematics 2022-04-14 Yuzhen Fan , Xiaoyu Zhang , Chuanhou Gao

Stability is a fundamental property of dynamical systems, yet to this date it has had little bearing on the practice of recurrent neural networks. In this work, we conduct a thorough investigation of stable recurrent models. Theoretically,…

Machine Learning · Computer Science 2019-03-05 John Miller , Moritz Hardt

Reaction networks are commonly used to model the evolution of populations of species subject to transformations following an imposed stoichiometry. This paper focuses on the efficient characterisation of dynamical properties of Discrete…

Discrete Mathematics · Computer Science 2013-07-15 Loïc Paulevé , Gheorghe Craciun , Heinz Koeppl

The fundamental decomposition of a chemical reaction network (CRN) is induced by partitioning the reaction set into "fundamental classes". It was the basis of the Higher Deficiency Algorithm for mass action systems of Ji and Feinberg, and…

Dynamical Systems · Mathematics 2020-08-13 Bryan S. Hernandez

Proposals for molecular communication networks as part of a future internet of bio-nano-things have become more intricate and the question of practical implementation is gaining more importance. One option is to apply detailed chemical…

Emerging Technologies · Computer Science 2024-11-20 Alexander Wietfeld , Marina Wendrich , Sebastian Schmidt , Wolfgang Kellerer