English
Related papers

Related papers: A solid approach to biopharmaceutical stabilisatio…

200 papers

Recent experiments have reported lower critical solution temperature (LCST) phase behavior of aqueous solutions of proteins induced by multivalent ions, where the solution phase separates upon heating. This phenomenon is linked to complex…

Soft Condensed Matter · Physics 2021-12-21 Anil Kumar Sahoo , Frank Schreiber , Roland R. Netz , Prabal K. Maiti

We investigate the finite-temperature phase diagram of polar molecules confined in a quasi-two-dimensional geometry by a harmonic potential along the polarization axis. We employ Quantum Monte Carlo simulations to explore the strongly…

Quantum Gases · Physics 2026-05-19 Vinicius Zampronio , Matteo Ciardi , Fabio Cinti

In this study we synthesized thin films of titanium oxide doped with thulium and/or ytterbium to modify the incident spectrum on the solar cells. This could be achieved either by photoluminescence up-converting devices, or down-converting…

$\alpha$-Li$_3$PS$_4$ is a promising solid-state electrolyte with the highest ionic conductivity among its polymorphs. However, its formation presents a thermodynamic paradox: the $\alpha$-phase is the equilibrium phase at high temperature…

We experimentally demonstrate stable trapping and controlled manipulation of silica microspheres in a structured optical beam consisting of a dark focus surrounded by light in all directions - the so-called Dark Focus Tweezer. Results from…

Cryopreservation via vitrification requires loading cryoprotective cocktails. Insufficient loading may lead to freezing, precluding successful recovery; overloading is toxic. Yet, existing in situ measurements of cryoprotectant permeation…

Entangled multiphoton states lie at the heart of quantum information, computing, and communications. In recent years, topology has risen as a new avenue to robustly transport quantum states in the presence of fabrication defects, disorder…

DNA-coated colloids can crystallize into a multitude of lattices, ranging from face-centered cubic to diamond and thereby contribute to our understanding of crystallization and open avenues to producing structures with useful photonic…

Soft Condensed Matter · Physics 2026-04-17 Pepijn G. Moerman , Huang Fang , Thomas E. Videbæk , W. Benjamin Rogers , Rebecca Schulman

In this paper, we present a decision support framework for optimizing multiple aspects of vaccine distribution across a multitier cold chain network. We propose two multi-period optimization formulations within this framework: first to…

Physics and Society · Physics 2022-01-12 Shanmukhi Sripada , Ayush Jain , Prasanna Ramamoorthy , Varun Ramamohan

Gallium selenide (GaSe) is a novel two-dimensional material, which belongs to the layered III-VIA semiconductors family and attracted interest recently as it displays single-photon emitters at room temperature and strong optical…

Triethylsilylethynyl anthradithiophene (TESADT) holds considerable promise for organic transistor applications due to the high electrical mobilities attained by post-deposition crystallization using solvent vapour annealing. We have studied…

Materials Science · Physics 2014-04-08 K. Muhieddine , R. W. Lyttleton , J. Badcock , M. A. Loth , J. Stride , J. E. Anthony , A. P. Micolich

Generating entanglement by simply cooling a system into a stationary state which is highly entangled has many advantages. Schemes based on this idea are robust against parameter fluctuations, tolerate relatively large spontaneous decay…

Quantum Physics · Physics 2015-05-28 J. Busch , S. De , S. S. Ivanov , B. T. Torosov , T. P. Spiller , A. Beige

A thorough analysis of the stability of a coupled version of an inter-hemispheric 3-box model of Thermohaline Circulation (THC) is presented. This study follows a similarly structured analysis on an uncoupled version of the same model…

Atmospheric and Oceanic Physics · Physics 2009-11-10 Valerio Lucarini , Peter H. Stone

Deciphering how genes interpret information from the concentration of transcription factors (TFs) within the cell nucleus remains a fundamental question in gene regulation. Recent advancements have unveiled the heterogeneous distribution of…

Biological Physics · Physics 2024-11-07 Rahul Munshi , Jia Ling , Sergey Ryabichko , Eric F Wieschaus , Thomas Gregor

We determine the speed of a crystallisation (or more generally, a solidification) front as it advances into the uniform liquid phase after the system has been quenched into the crystalline region of the phase diagram. We calculate the front…

Soft Condensed Matter · Physics 2013-03-25 A. J. Archer , M. J. Robbins , U. Thiele , E. Knobloch

Protein engineering enables the creation of tailor-made proteins for an array of applications. ImmTACs stand out as promising therapeutics for cancer and other treatments, while also presenting unique challenges for stability, formulation…

Soft Condensed Matter · Physics 2024-06-25 Emily Sakamoto-Rablah , Jordan Bye , Arghya Modak , Andrew Hooker , Shahid Uddin , Jennifer J McManus

Crystallization of proteins, specifically proteins of medical relevance, is performed for various reasons such as to understand the protein structure and to design therapies. Obtaining kinetic constants in rate laws for nucleation and…

Separation and transportation of small particles are important processes in various applications such as the food and pharmaceutical industries. Although mechanical, chemical or electrical methods can provide possible solutions, operational…

Non-linear absorption phenomena induced by controlled irradiation with a femtosecond laser beam can be used to tailor materials properties within the bulk of substrates. One of the most successful applications of this technique is the…

Enhanced stabilisation of protein structures via the presence of inert excipients is a key mechanism adopted both by physiological systems and in biotechnological applications. While the intrinsic stability of proteins is ultimately fixed…

Biomolecules · Quantitative Biology 2023-05-10 Mattia Miotto , Nina Warner , Giancarlo Ruocco , Gian Gaetano Tartaglia , Oren A. Scherman , Edoardo Milanetti