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Microtubules are inherently dynamic sub-cellular filamentuous polymers that are spatially organized within the cell by motor proteins which cross-link and move microtubules. In-vitro microtubule motility assays, in which motors attached to…

Quantitative Methods · Quantitative Biology 2020-01-22 Samira Masoudi , Cameron H. G. Wright , Nazanin Rahnavard , Jay C. Gatlin , John S. Oakey

Active filaments, such as microtubules with attached cargo-carrying motor proteins, are important dynamic structures for fluid transport in and around living cells. The mathematical models of active filaments appearing in the literature…

Fluid Dynamics · Physics 2025-08-19 Ilteber R. Ozdemir , Bethany Clarke , Yongyun Hwang , Eric E. Keaveny

We report an extensive and systematic investigation of the multi-point and multi-time correlation functions to reveal the spatio-temporal structures of dynamic heterogeneities in glass-forming liquids. Molecular dynamics simulations are…

Soft Condensed Matter · Physics 2013-01-04 Kang Kim , Shinji Saito

We study the dynamics of a tunable 2D active nematic liquid crystal composed of microtubules and kinesin motors confined to an oil-water interface. Kinesin motors continuously inject mechanical energy into the system through ATP hydrolysis,…

Soft Condensed Matter · Physics 2019-09-10 Linnea M Lemma , Stephen J Decamp , Zhihong You , Luca Giomi , Zvonimir Dogic

We use optical trapping to continuously bend an isolated microtubule while simultaneously measuring the applied force and the resulting filament strain, thus allowing us to determine its elastic properties over a wide range of applied…

Biological Physics · Physics 2018-07-24 Edvin Memet , Feodor Hilitski , Margaret A Morris , Walter J Schwenger , Zvonimir Dogic , L Mahadevan

The dynamics of microcapsules in steady shear flow was studied using a theoretical approach based on three variables: The Taylor deformation parameter $\alpha_{\rm D}$, the inclination angle $\theta$, and the phase angle $\phi$ of the…

Soft Condensed Matter · Physics 2015-05-18 Hiroshi Noguchi

Active nematics are out-of-equilibrium systems in which energy injection at the microscale drives emergent collective behaviors, from spontaneous flows to active turbulence. While the dynamics of these systems have been extensively studied,…

Soft Condensed Matter · Physics 2025-04-15 Ahmet Umut Akduman , Yusuf Sariyar , Giuseppe Negro , Livio Nicola Carenza

The formation, maintenance and reorganization of the cytoskeletal filament network is essential for a number of cellular processes. While the crucial role played by active forces generated by motor proteins has been studied extensively,…

Biological Physics · Physics 2019-01-30 Sougata Guha , Subhadip Ghosh , Ignacio Pagonabarraga , Sudipto Muhuri

The dynamic behavior of microtubules in solution can be strongly modified by interactions with walls or other structures. We examine here a microtubule growth model where the increase in size of the plus-end is perturbed by collisions with…

Soft Condensed Matter · Physics 2010-09-29 Vladimir A. Baulin , Carlos M. Marques , Fabrice Thalmann

Anisotropic macromolecules exposed to non-equilibrium (active) noise are very common in biological systems, and an accurate understanding of their anisotropic dynamics is therefore crucial. Here, we experimentally investigate the dynamics…

Soft Condensed Matter · Physics 2020-07-08 Mehdi Shafiei Aporvari , Mustafa Utkur , Emine Ulku Saritas , Giovanni Volpe , Joakim Stenhammar

We provide a minimal model for an active nematic film in contact with both a solid substrate and a passive isotropic fluid, and explore its dynamics in one and two dimensions using a combination of hybrid Lattice Boltzmann simulations and…

Soft Condensed Matter · Physics 2017-02-16 Matthew L. Blow , Marco Aqil , Benno Liebchen , Davide Marenduzzo

Active solids such as cell collectives, colloidal clusters, and active metamaterials exhibit diverse collective phenomena, ranging from rigid body motion to shape-changing mechanisms. The nonlinear dynamics of such active materials remains…

Soft Condensed Matter · Physics 2024-06-21 Claudio Hernández-López , Paul Baconnier , Corentin Coulais , Olivier Dauchot , Gustavo Düring

Intracellular transport of vesicular cargos, organelles, and other macromolecules is an essential process to move large items through a crowded, and inhomogeneous cellular environment. In an effort to dissect the fundamental effects of…

Biomolecules · Quantitative Biology 2014-09-12 Leslie Conway , Jennifer L. Ross

Active dynamic processes of cells are largely driven by the cytoskeleton, a complex and adaptable semiflexible polymer network, motorized by mechanoenzymes. Small dimensions, confined geome- tries and hierarchical structures make it…

Biological Physics · Physics 2017-08-23 Jannes Gladrow , Chase P. Broedersz , Christoph F. Schmidt

Motor proteins drive persistent motion and self-organisation of cytoskeletal filaments. However, state-of-the-art microscopy techniques and continuum modelling approaches focus on large length and time scales. Here, we perform…

Soft Condensed Matter · Physics 2024-06-03 Gerrit Vliegenthart , Arvind Ravichandran , Marisol Ripoll , Thorsten Auth , Gerhard Gompper

Because of consuming energy to drive their motion, systems of active colloids are intrinsically out of equilibrium. In the past decade, a variety of intriguing dynamic patterns have been observed in systems of active colloids, and they…

Soft Condensed Matter · Physics 2020-04-16 Zhan Ma , Mingcheng Yang , Ran Ni

The concept of creating all-mechanical soft microrobotic systems has great potential to address outstanding challenges in biomedical applications, and introduce more sustainable and multifunctional products. To this end, magnetic fields and…

Applied Physics · Physics 2022-05-26 Murat Kaynak , Amit Dolev , Mahmut Selman Sakar

We study the hydrodynamic behavior of three dimensional (3D) incompressible collections of self-propelled entities in contact with a momentum sink in a state with non-zero average velocity, hereafter called 3D easy-plane incompressible…

Soft Condensed Matter · Physics 2018-10-31 Leiming Chen , Chiu Fan Lee , John Toner

Collective behaviour in suspensions of microswimmers is often dominated by the impact of long-ranged hydrodynamic interactions. These phenomena include active turbulence, where suspensions of pusher bacteria at sufficient densities exhibit…

Soft Condensed Matter · Physics 2019-08-27 Dora Bardfalvy , Henrik Nordanger , Cesare Nardini , Alexander Morozov , Joakim Stenhammar

Kinesin is a molecular motor that transports cargo along microtubules. The results of many {\it in vitro} experiments on kinesin-1 are described by kinetic models \cite{Clancy11} in which one transition corresponds to the forward motion and…

Statistical Mechanics · Physics 2018-05-30 Gert Knoops , Carlo Vanderzande
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