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This study creates a physiologically realistic virtual patient database (VPD), representing the human arterial system, for the primary purpose of studying the affects of arterial disease on haemodynamics. A low dimensional representation of…

Medical Physics · Physics 2021-08-05 Gareth Jones , Jim Parr , Perumal Nithiarasu , Sanjay Pant

Cardiovascular waveforms contain information for clinical diagnosis. By "learning" and organizing the subtle change of waveform morphology from large amounts of raw waveform data, unsupervised manifold learning helps delineate a…

Quantitative Methods · Quantitative Biology 2019-12-03 Shen-Chih Wang , Hau-Tieng Wu , Po-Hsun Huang , Cheng-Hsi Chang , Chien-Kun Ting , Yu-Ting Lin

We investigate through high resolution 3D simulations the nonlinear evolution of compressible magnetohydrodynamic flows subject to the Kelvin-Helmholtz instability. We confirm in 3D flows the conclusion from our 2D work that even apparently…

Astrophysics · Physics 2009-10-31 Dongsu Ryu , T. W. Jones , Adam Frank

For the clarification of the routes to elasto-inertial turbulence (EIT), it is essential to understand how viscoelasticity modulates coherent flow structures including the longitudinal vortices. We focused on a rotating plane Couette flow…

Fluid Dynamics · Physics 2019-09-11 Tomohiro Nimura , Takuya Kawata , Takahiro Tsukahara

Mathematical models are widely recognized as a valuable tool for cardiovascular diagnosis and the study of circulatory diseases, especially to obtain data that require otherwise invasive measurements. To correctly simulate body…

Flow in channels and ducts with adjoining cavities are common in natural and engineered systems. Here we report numerical and experimental results of 3D confined cavity flow, identifying critical conditions in the recirculating flow…

Fluid Dynamics · Physics 2021-01-19 Reem Khojah , Darren Lo , Fiona Tang , Dino Di Carlo

We investigate the behaviour of accelerating contact lines in an unsteady quasi-capillary channel flow. The configuration consists of a liquid column that moves along a vertical 2D channel, open to the atmosphere and driven by a controlled…

Fluid Dynamics · Physics 2022-05-11 Manuel Ratz , Domenico Fiorini , Alessia Simonini , Christian Cierpka , Miguel A. Mendez

Wall-driven flow in square cavity has been studied extensively, yet it is more frequently for the rectangular cavity flow occurring in practical problems, and some flow characteristics about rectangular cavity have not been fully…

Fluid Dynamics · Physics 2022-11-10 Xiuqiao Xiang , Baochang Shi

Surface distortions to an otherwise planar channel flow introduce vorticity perturbations. We examine this scenario in viscoelastic fluids, and identify new mechanisms by which significant vorticity perturbations can be generated in both…

Fluid Dynamics · Physics 2021-10-11 Jacob Page , Tamer A. Zaki

We performed numerical simulations of blood flow in arteries with a variable stiffness and cross-section at rest using a finite volume method coupled with a hydrostatic reconstruction of the variables at the interface of each mesh cell. The…

Numerical Analysis · Mathematics 2015-09-15 Olivier Delestre , Arthur Ghigo , Jose-Maria Fullana , Pierre-Yves Lagrée

Atherosclerosis is a state wherein plaque (fat, cholesterol, and different substances) develops inside the veins that in the end prompts carotid artery stenosis which is a phase of narrowing in the huge courses situated on either side of…

Medical Physics · Physics 2021-08-03 Nihal Ahmed , Ashfaq Ahmed , Sakan Binte Imran

$\textbf{Purpose:}$ To develop a new method for free-breathing 3D extracellular volume (ECV) mapping of the whole heart at 3T. $\textbf{Methods:}$ A free-breathing 3D cardiac ECV mapping method was developed at 3T. T1 mapping was performed…

Large Eddy Simulation (LES) with dynamic sub-grid scale eddy viscosity model has been applied to numerically investigate the evolution of complicated flow structures in supersonic base flow with mass bleed. Mean flow properties obtained…

Fluid Dynamics · Physics 2021-02-15 Pratik Das , Ashoke De

A minimal model for mechanical motion of the left ventricle is proposed. The model assumes the left ventricle to be a harmonic oscillator with two distinct phases, simulating the systolic and diastolic phases, at which both the amplitude…

Medical Physics · Physics 2007-05-23 S. Dubi , C. Dubi , Y. Dubi

Flow fluctuations have recently emerged as a promising hemodynamic metric for understanding the rupture risk of intracranial aneurysms. Several investigations have reported in the literature corresponding flow instabilities using…

Fluid Dynamics · Physics 2023-06-05 Feng Huang , Seyed Ali Hosseini , Gabor Janiga , Dominique Thévenin

Background: Despite the recent advances in computational fluid dynamics (CFD) techniques applied to blood flow within the left atrium (LA), the relationship between atrial geometry, flow patterns, and blood stasis within the left atrial…

Automatic segmentation of the left ventricle (LV) in late gadolinium enhanced (LGE) cardiac MR (CMR) images is difficult due to the intensity heterogeneity arising from accumulation of contrast agent in infarcted myocardium. In this paper,…

Image and Video Processing · Electrical Eng. & Systems 2022-05-24 Dong Wei , Ying Sun , Sim-Heng Ong , Ping Chai , Lynette L. Teo , Adrian F. Low

In this work, we present a coupled 3D-1D model of solid tumor growth within a dynamically changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the model includes erosion of the extracellular matrix,…

Tissues and Organs · Quantitative Biology 2021-06-23 Marvin Fritz , Prashant K. Jha , Tobias Köppl , J. Tinsley Oden , Andreas Wagner , Barbara Wohlmuth

The clinical application of patient-specific modelling of the heart can provide valuable insights in supplementing and advancing methods of diagnosis as well as helping to devise the best possible therapeutic approach for each individual…

Medical Physics · Physics 2023-08-03 Sebastian Skatulla , Carlo Sansour , Mary Familusi , Jagir Hussan , Ntobeko Ntusi

The propagation characteristics of fluid vortices, particularly monopoles and dipoles, in a homogeneous viscoelastic fluid were reported in a recent publication [ Phys. Plasmas 23, 013707 (2016)]. In that study, a dusty plasma was modeled…

Fluid Dynamics · Physics 2025-05-13 Vipul B. Rohit , Vikram S. Dharodi , Sharad K. Yadav
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