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Historically, patient datasets have been used to develop and validate various reconstruction algorithms for PET/MRI and PET/CT. To enable such algorithm development, without the need for acquiring hundreds of patient exams, in this paper we…

We present a novel approach for benchmarking and validating quantitative phase tomography (QPT) systems using three-dimensional microphantoms. These microphantoms, crafted from biological and imaging data, replicate the optical and…

Cone beam computed tomography (CBCT) for breast imaging has potential to replace conventional mammograms. However, concerns over dose and image quality prevent CBBCT systems from the clinical trial phase to next stage. The time of flight…

Medical Physics · Physics 2021-02-01 Ignacio O. Romero , Changqing Li

Fluorescence microscopy is widely employed for the analysis of living biological samples; however, the utility of the resulting recordings is frequently constrained by noise, temporal variability, and inconsistent visualisation of signals…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Hassan Eshkiki , Sarah Costa , Mostafa Mohammadpour , Farinaz Tanhaei , Christopher H. George , Fabio Caraffini

We consider different approaches to simulate a modern X-ray beamline. Several methodologies with increasing complexity are applied to discuss the relevant parameters that quantify the beamline performance. Parameters such as flux,…

To reconstruct a radioactive tracer distribution with positron emission tomography (PET), the background attenuation correction is needed to eliminate image artifacts. Recent research shows that time-of-flight (TOF) PET data determine the…

Medical Physics · Physics 2013-12-30 Qingsong Yang , Wenxiang Cong , Ge Wang

A Python package for the analysis of dark-field X-ray microscopy (DFXM) and rocking curve imaging (RCI) data is presented. \textit{darfix} provides a set of data processing and visualization tools that can be either imported as library…

X-ray images play a vital role in the intraoperative processes due to their high resolution and fast imaging speed and greatly promote the subsequent segmentation, registration and reconstruction. However, over-dosed X-rays superimpose…

Image and Video Processing · Electrical Eng. & Systems 2024-08-01 Lixing Tan , Shuang Song , Kangneng Zhou , Chengbo Duan , Lanying Wang , Huayang Ren , Linlin Liu , Wei Zhang , Ruoxiu Xiao

We report the first experimental test of an analytic image reconstruction algorithm for optical tomography with large data sets. Using a continuous-wave optical tomography system with 10^8 source-detector pairs, we demonstrate the…

Medical Physics · Physics 2007-05-23 Zheng-Min Wang , George Y. Panasyuk , Vadim A. Markel , John C. Schotland

Biological soft tissues encountered in clinical and pre-clinical imaging mainly consist of light element atoms, and their composition is nearly uniform with little density variation. Thus, x-ray attenuation imaging suffers from low image…

Medical Physics · Physics 2011-06-28 Wenxiang Cong , Atsushi Momose , Ge Wang

With the increasing complexity of external beam therapy, so-called "end-to-end" tests are intended to cover all steps from therapy planning to follow-up to fulfill the high demands on quality assurance. As magnetic resonance imaging (MRI)…

In this paper we propose a new joint model for the reconstruction of tomography data under limited angle sampling regimes. In many applications of Tomography, e.g. Electron Microscopy and Mammography, physical limitations on acquisition…

Synchrotron radiation-based X-ray microtomography is uniquely suited for post mortem three-dimensional visualization of organs such as the mouse brain. Tomographic imaging of the entire mouse brain with isotropic cellular resolution…

In this article, we demonstrate the viability of highly monochromatic full-field X-ray absorption near edge structure based tomography using a laboratory-scale Johann-type X-ray absorption spectrometer based on a conventional X-ray tube…

Instrumentation and Detectors · Physics 2022-10-04 Ari-Pekka Honkanen , Simo Huotari

In conventional x-ray ptychography, diffraction data is collected by scanning a sample through a monochromatic, and spatially coherent, x-ray beam. A high-resolution image is then retrieved using an iterative algorithm. Combined with a scan…

Optics · Physics 2025-08-26 Wiebe Stolp , Silvia Cipiccia , Darren Batey , Matthieu Boone

Implementation of real-time, continuous, and three-dimensional imaging (4D intervention guidance) would be a quantum leap for minimally-invasive medicine. It allows guidance during interventions by assessing the spatial position of…

Medical Physics · Physics 2016-10-17 Sönke Bartling , Marc Kachelrieß

Flow instabilities such as Haines jumps in porous media are common phenomena that occur on sub-second timescales. X-rays are particularly suitable for investigating these processes because they provide non-destructive three-dimensional…

In ghost imaging schemes information about an object is extracted by measuring the correlation between a beam that passed the object and a reference beam. We present a spatial averaging technique that substantially improves the imaging…

Quantum Physics · Physics 2009-11-10 M. Bache , E. Brambilla , A. Gatti , L. A. Lugiato

Recently, there has been increased attention towards 3D imaging using single-pixel single-photon detection (also known as temporal data) due to its potential advantages in terms of cost and power efficiency. However, to eliminate the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-28 Tingqin Lai , Xiaolin Liang , Yi Zhu , Xinyi Wu , Lianye Liao , Xuelin Yuan , Ping Su , Shihai Sun

X-ray computed tomography (CT) is widely utilized in the medical, industrial, and other fields to nondestructively generate three-dimensional structural images of objects. However, CT images are often affected by various artifacts, with…

Medical Physics · Physics 2025-05-27 Yang Zou , Meili Qi , Jianhua Zhang , Difei Zhang , Shuwei Wang , Jiale Zhang , Shengkun Yao , Huaidong Jiang
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