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The classical theory for the meta-analysis of $p$-values is based on the assumption that if the overall null hypothesis is true, then all $p$-values used in a chosen combined test statistic are genuine, i.e., are observations from…

Computation · Statistics 2024-10-08 Rui Santos , M. Fátima Brilhante , Sandra Mendonça

Functional Magnetic Resonance Imaging~(fMRI) is widely used to study activation in the human brain. In most cases, data are commonly used to construct activation maps corresponding to a given paradigm. Results can be very variable, hence…

Applications · Statistics 2022-05-04 Ranjan Maitra

Psychiatric disorders have historically been classified using symptom information alone. With the advent of new technologies that allowed researchers to investigate brain mechanisms more directly, interest in the mechanistic rationale…

Neurons and Cognition · Quantitative Biology 2020-07-02 Lucas Miranda , Riya Paul , Benno Pütz , Bertram Müller-Myhsok

Recent advances in vision-language models (VLMs) reasoning have been largely attributed to the rise of reinforcement Learning (RL), which has shifted the community's focus away from the supervised fine-tuning (SFT) paradigm. Many studies…

Permutation tests are amongst the most commonly used statistical tools in modern genomic research, a process by which p-values are attached to a test statistic by randomly permuting the sample or gene labels. Yet permutation p-values…

Applications · Statistics 2016-03-21 Belinda Phipson , Gordon K. Smyth

Functional magnetic resonance imaging (fMRI) is a powerful tool for investigating human brain function. However, the high cost of data acquisition and the inherent subjectivity of psychiatric rating scales often lead to datasets with small…

Machine Learning · Computer Science 2026-05-29 Jiyao Wang , Peiyu Duan , Nicha C. Dvornek , Lawrence H. Staib , Denis Sukhodolsky , Pamela Ventola , James S. Duncan

Non-markovian Reinforcement Learning (RL) tasks are very hard to solve, because agents must consider the entire history of state-action pairs to act rationally in the environment. Most works use symbolic formalisms (as Linear Temporal Logic…

Machine Learning · Computer Science 2024-08-19 Elena Umili , Francesco Argenziano , Roberto Capobianco

Selective inference (SI) has been actively studied as a promising framework for statistical hypothesis testing for data-driven hypotheses. The basic idea of SI is to make inferences conditional on an event that a hypothesis is selected. In…

Machine Learning · Statistics 2023-12-29 Tomohiro Shiraishi , Daiki Miwa , Vo Nguyen Le Duy , Ichiro Takeuchi

Pathology image analysis is an essential procedure for clinical diagnosis of many diseases. To boost the accuracy and objectivity of detection, nowadays, an increasing number of computer-aided diagnosis (CAD) system is proposed. Among these…

Computer Vision and Pattern Recognition · Computer Science 2021-05-11 Yixin Li , Chen Li , Xiaoyan Li , Kai Wang , Md Mamunur Rahaman , Changhao Sun , Hao Chen , Xinran Wu , Hong Zhang , Qian Wang

Functional magnetic resonance imaging (fMRI) is a non-invasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associations between brain regions, either while study subjects…

Applications · Statistics 2024-03-26 Kun Meng , Ani Eloyan

Supervised Fine-Tuning (SFT) is widely used for task-specific adaptation, yet recent work shows it systematically undermines reasoning generalization. We argue the root cause is not memorization itself, but its target: vanilla SFT drives…

Machine Learning · Computer Science 2026-05-26 Ruiying Peng , Mengyu Yang , Jing Lei , Xiaohui Li , Xueyu Wu , Xinlei Chen

Graph neural networks (GNN) have emerged as a popular tool for modelling functional magnetic resonance imaging (fMRI) datasets. Many recent studies have reported significant improvements in disorder classification performance via more…

Machine Learning · Computer Science 2026-04-27 Yi Hao Chan , Deepank Girish , Sukrit Gupta , Jing Xia , Chockalingam Kasi , Yinan He , Conghao Wang , Jagath C. Rajapakse

Supervised operator learning centers on the use of training data, in the form of input-output pairs, to estimate maps between infinite-dimensional spaces. It is emerging as a powerful tool to complement traditional scientific computing,…

Machine Learning · Computer Science 2024-08-14 Nicholas H. Nelsen , Andrew M. Stuart

Saliency methods are a popular class of feature attribution explanation methods that aim to capture a model's predictive reasoning by identifying "important" pixels in an input image. However, the development and adoption of these methods…

Machine Learning · Computer Science 2022-06-20 Joon Sik Kim , Gregory Plumb , Ameet Talwalkar

Random Forest (RFs) are among the most widely used Machine Learning (ML) classifiers. Even though RFs are not interpretable, there are no dedicated non-heuristic approaches for computing explanations of RFs. Moreover, there is recent work…

Machine Learning · Computer Science 2021-05-24 Yacine Izza , Joao Marques-Silva

Increased availability of data and accessibility of computational tools in recent years have created unprecedented opportunities for scientific research driven by statistical analysis. Inherent limitations of statistics impose constrains on…

Genomics · Quantitative Biology 2016-09-13 Olga A. Vsevolozhskaya , Gabriel Ruiz , Dmitri V. Zaykin

In contrast to conventional, univariate analysis, various types of multivariate analysis have been applied to functional magnetic resonance imaging (fMRI) data. In this paper, we compare two contemporary approaches for multivariate…

Applications · Statistics 2018-02-08 Ethan C. Jackson , James Alexander Hughes , Mark Daley

We are concerned with multiple test problems with composite null hypotheses and the estimation of the proportion $\pi_{0}$ of true null hypotheses. The Schweder-Spj\o tvoll estimator $\hat{\pi}_0$ utilizes marginal $p$-values and only works…

Methodology · Statistics 2020-04-20 Anh-Tuan Hoang , Thorsten Dickhaus

Fisher's randomization test (FRT) delivers exact $p$-values under the strong null hypothesis of no treatment effect on any units whatsoever and allows for flexible covariate adjustment to improve the power. Of interest is whether the…

Methodology · Statistics 2021-05-03 Anqi Zhao , Peng Ding

The prevailing paradigm for training large reasoning models--combining Supervised Fine-Tuning (SFT) with Reinforcement Learning with Verifiable Rewards (RLVR)--is fundamentally constrained by its reliance on high-quality, human-annotated…

Machine Learning · Computer Science 2026-03-24 Yuanfu Wang , Zhixuan Liu , Xiangtian Li , Chaochao Lu , Chao Yang