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Endoscopic optical coherence tomography (OCT) is a valuable tool for providing diagnostic images of internal organs and guiding interventions in real time. Miniaturized OCT endoscopes are essential for imaging small and convoluted luminal…

Instrumentation and Detectors · Physics 2023-11-28 Chao Xu , Xin Guan , Syeda Aimen Abbasi , Neng Xia , To Ngai , Li Zhang , Ho-Pui Ho , Sze Hang Calvin Ng , Wu Yuan

We develop a curvilinear invariant set of the diffusion tensor which may be applied to Diffusion Tensor Imaging measurements on tissues and porous media. This new set is an alternative to the more common invariants such as fractional…

Biological Physics · Physics 2014-01-03 Robin A. Damion , Aleksandra Radjenovic , Eileen Ingham , Zhongmin Jin , Michael E. Ries

The latest applications in ultrafast quantum metrology require bright, broadband bi-photon sources with one of the photons in the mid-infrared and the other in the visible to near infrared. However, existing sources based on bulk crystals…

Bilateral filtering (BF) is one of the most classical denoising filters, however, the manually initialized filtering kernel hampers its adaptivity across images with various characteristics. To deal with image variation (i.e.,…

Computer Vision and Pattern Recognition · Computer Science 2019-12-24 Feihong Liu , Jun Feng , Pew-Thian Yap , Dinggang Shen

Fast, volumetric imaging over large scales has been a long-standing goal in biological microscopy. Scanning techniques such as fluorescence confocal microscopy can acquire 2D images at high resolution and high speed, but extending the…

Two-Photon Microscopy has become an invaluable tool for biological and medical research, providing high sensitivity, molecular specificity, inherent three-dimensional sub-cellular resolution and deep tissue penetration. In terms of imaging…

Wavefront shaping is a powerful method to refocus light through a scattering medium. Its application to large spectral bandwidths or multiple wavelengths refocusing for nonlinear bio-imaging in-depth is however limited by spectral…

Two-Photon Laser-Scanning Microscopy is a powerful tool for exploring biological structure and function because of its ability to optically section through a sample with a tight focus. While it is possible to obtain 3D image stacks by…

Biological Physics · Physics 2020-01-08 Courtney Johnson , Jack Exell , Jonathon Kuo , Kevin Welsher

Focusing light through dynamically varying heterogeneous media is a sought-after goal with important applications ranging from free-space communication to nano-surgery. The underlying challenge is to control the optical wavefront with a…

Ring-core optical fibers have been designed to carry orbital angular momentum modes. We demonstrate the imaging of these modes, individually identifying modes separated temporally by only 30~ps. A single-pixel camera operating in the…

Optics · Physics 2019-08-23 Steven D. Johnson , Zelin Ma , Miles Padgett , Siddharth Ramachandran

In this work we demonstrate 3D imaging using two-photon excitation through a 20 cm long multimode optical fiber (MMF) of 350 micrometers diameter. The imaging principle is similar to single photon fluorescence through a MMF, except that a…

Optics · Physics 2016-01-20 Edgar E. Morales-Delgado , Demetri Psaltis , Christophe Moser

We demonstrate focusing and imaging through a scattering medium noninvasively by using wavefront shaping. Our concept is based on utilizing the spatial fluorescence contrast which naturally exists in the hidden target object. By scanning…

Optics · Physics 2019-07-25 Anat Daniel , Dan Oron , Yaron Silberberg

All coronagraphic instruments for exoplanet high-contrast imaging need wavefront correction systems to reject optical aberrations and create sufficiently dark holes. Since the most efficient wavefront correction algorithms (controllers and…

Instrumentation and Methods for Astrophysics · Physics 2018-10-09 He Sun , N. Jeremy Kasdin , Robert Vanderbei

Achieving atomic resolution in electron microscopy has historically been hindered by spherical aberration, a fundamental limitation of conventional electron lenses. Its correction typically requires complex assemblies of electromagnetic…

Fluorescent observation of cells generally suffers from the limited axial resolution due to the elongated point spread function of the microscope optics. Consequently, three-dimensional imaging results in axial resolution being several…

Adaptive optics is a strategy to compensate for sample-induced aberrations in microscopy applications. Generally, it requires the presence of "guide stars" in the sample to serve as localized reference targets. We describe an implementation…

Due to limited size and imperfect of the optical components in a spectrometer, aberration has inevitably been brought into two-dimensional multi-fiber spectrum image in LAMOST, which leads to obvious spacial variation of the point spread…

Instrumentation and Methods for Astrophysics · Physics 2020-10-28 Jiali Xu , Qian Yin , Ping Guo , Xin Zheng

Tissue stiffness is related to soft tissue pathologies and can be assessed through palpation or via clinical imaging systems, e.g., ultrasound or magnetic resonance imaging. Typically, the image based approaches are not suitable during…

Signal Processing · Electrical Eng. & Systems 2025-09-04 Maximilian Neidhardt , Sarah Latus , Tim Eixmann , Gereon Hüttmann , Alexander Schlaefer

Photonic flatbands offer promising light-matter interaction due to their unique slow-light nature. In recent years, flatbands have also attracted significant interest in optical engineering because of their angle-insensitive resonant…