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Related papers: Ultrafast imaging of cell elasticity with optical …

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The mechanical properties of cells play key roles in their physiology, function, physiological and pathological transformations. Micro-elastography has recently emerged as a promising tool to estimate cellular viscoelastic properties within…

Visualizing elastic waves by noninvasive imaging has been useful for analyzing the mechanical properties of materials and tissues. However, the maximum wave frequency of elastography has been limited to ~10 kHz due to the finite sensitivity…

Applied Physics · Physics 2022-11-22 Xu Feng , Guo-Yang Li , Seok-Hyun Yun

Objective - Shear wave elastography has enriched ultrasound medical imaging with quantitative measurements of tissue stiffness. However, this method still suffers from some limitations due to viscoelasticity, guiding geometry or static…

Soft Condensed Matter · Physics 2023-12-25 Alexandre Delory , Daniel A. Kiefer , Claire Prada , Fabrice Lemoult

Ultrasound shear wave elasticity imaging is a valuable tool for quantifying the elastic properties of tissue. Typically, the shear wave velocity is derived and mapped to an elasticity value, which neglects information such as the shape of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-29 Maximilian Neidhardt , Marcel Bengs , Sarah Latus , Stefan Gerlach , Christian J. Cyron , Johanna Sprenger , Alexander Schlaefer

Rapid mapping of the mechanical properties of soft biological tissues from light microscopy to macroscopic imaging could transform fundamental biophysical research by providing clinical biomarkers to complement in vivo elastography. We here…

Mechanical properties of tissue provide valuable information for identifying lesions. One approach to obtain quantitative estimates of elastic properties is shear wave elastography with optical coherence elastography (OCE). However, given…

Image and Video Processing · Electrical Eng. & Systems 2020-04-30 Maximilian Neidhardt , Marcel Bengs , Sarah Latus , Matthias Schlüter , Thore Saathoff , Alexander Schlaefer

Shear wave elastography involves applying a non-invasive acoustic radiation force to the tissue and imaging the induced deformation to infer its mechanical properties. This work investigates the use of convolutional neural networks to…

Image and Video Processing · Electrical Eng. & Systems 2024-04-29 Remi Delaunay , Yipeng Hu , Tom Vercauteren

Optical coherence elastography (OCE) is a powerful non-invasive imaging technique for high-resolution assessment of tissue elasticity and viscoelasticity. Accurate characterization of viscoelastic properties requires estimating shear wave…

Tissue stiffness is related to soft tissue pathologies and can be assessed through palpation or via clinical imaging systems, e.g., ultrasound or magnetic resonance imaging. Typically, the image based approaches are not suitable during…

Signal Processing · Electrical Eng. & Systems 2025-09-04 Maximilian Neidhardt , Sarah Latus , Tim Eixmann , Gereon Hüttmann , Alexander Schlaefer

Robot-assisted surgery has advantages compared to conventional laparoscopic procedures, e.g., precise movement of the surgical instruments, improved dexterity, and high-resolution visualization of the surgical field. However, mechanical…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Maximilian Neidhardt , Robin Mieling , Sarah Latus , Martin Fischer , Tobias Maurer , Alexander Schlaefer

Traveling-wave optical coherence elastography (OCE) is a promising technique to measure the stiffness of biological tissues. While OCE has been applied to relatively homogeneous samples, tissues with significantly varying elasticity through…

Medical Physics · Physics 2022-01-31 Xu Feng , Guo-Yang Li , Antoine Ramier , Amira M. Eltony , Seok-Hyun Yun

Using shear wave elastography, we measure the changes in the wave speed with the stress produced by a striated muscle during isometric voluntary contraction. To isolate the behaviour of an individual muscle from complementary or…

Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the…

Medical Physics · Physics 2023-07-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

Microrheology, the study of fluids on micron length-scales, promises to reveal insights into cellular biology, including mechanical biomarkers of disease and the interplay between biomechanics and cellular function. Here a…

Ultrasound is a continually developing technology that is broadly used for fast, non-destructive mechanical property detection of hard and soft materials in applications ranging from manufacturing to biomedical. In this study, a novel…

Medical Physics · Physics 2019-10-17 Yuqi Jin , Ezekiel Walker , Arkadii Krokhin , Hyeonu Heo , Tae-Youl Choi , Arup Neogi

It is known that changes in the mechanical properties of tissues are associated with the onset and progression of certain diseases. Ultrasound elastography is a technique to characterize tissue stiffness using ultrasound imaging either by…

Image and Video Processing · Electrical Eng. & Systems 2020-11-22 Hongliang Li , Manish Bhatt , Zhen Qu , Shiming Zhang , Martin C. Hartel , Ali Khademhosseini , Guy Cloutier

This article describes a novel quasi-real time system for quantitative and volumetric measurement of tissue elasticity in the prostate. Tissue elasticity is computed by using a local frequency estimator to measure the three dimensional…

The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography,…

Biological Physics · Physics 2025-07-29 Yuxuan Jiang , Guo-Yang Li , Ruizhi Wang , Xu Feng , Yanhang Zhang , Seok-Hyun Yun

The role and importance of mechanical properties of cells and tissues in cellular function, development as well as disease has widely been acknowledged, however standard techniques currently used to assess them exhibit intrinsic…

Biological Physics · Physics 2019-01-09 Robert Prevedel , Alba Diz-Muñoz , Giancarlo Ruocco , Giuseppe Antonacci

Accurately measuring cell stiffness is challenging due to the invasiveness of traditional methods like atomic force microscopy (AFM) and optical stretching. We introduce a non-invasive off-axis system using holographic imaging and acoustic…

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