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X-ray crystallography is the predominant method for obtaining atomic-scale information about biological macromolecules. Despite the success of the technique, obtaining well diffracting crystals still critically limits going from protein to…
The radioactive glucose analogue 2-deoxy-2-[18F]fluoro-D-glucose (FDG) is widely used to reconstruct glucose metabolism and other biological functions in cells and tissues. The analysis of data on the time course of FDG tracer distribution…
Objective: The design of an Artificial Pancreas (AP) to regulate blood glucose levels requires reliable control methods. Model Predictive Control has emerged as a promising approach for glycemia control. However, model--based control…
Wireless capsule endoscopy (WCE) is a process in which a patient swallows a camera-embedded pill-shaped device that passes through the gastrointestinal (GI) tract, captures and transmits images to an external receiver. WCE devices are…
Control of blood glucose is essential for diabetes management. Current digital therapeutic approaches for subjects with Type 1 diabetes mellitus (T1DM) such as the artificial pancreas and insulin bolus calculators leverage machine learning…
Objective: Numerous glucose prediction algorithm have been proposed to empower type 1 diabetes (T1D) management. Most of these algorithms only account for input such as glucose, insulin and carbohydrate, which limits their performance.…
Rapid diagnosis of gastric cancer is a great challenge for clinical doctors. Dramatic progress of computer vision on gastric cancer has been made recently and this review focuses on advances during the past five years. Different methods for…
Tumor segmentation in medical imaging is crucial and relies on precise delineation. Fluorodeoxyglucose Positron-Emission Tomography (FDG-PET) is widely used in clinical practice to detect metabolically active tumors. However, FDG-PET scans…
Tumor growth is a complex process characterized by uncontrolled cell proliferation and invasion of neighboring tissues. The understanding of these phenomena is of vital importance to establish appropriate diagnosis and therapeutic strategy…
Cancer is a highly heterogeneous condition that can occur almost anywhere in the human body. 18F-fluorodeoxyglucose is an imaging modality commonly used to detect cancer due to its high sensitivity and clear visualisation of the pattern of…
Effective postprandial glucose control is important to glucose management for subjects with diabetes mellitus. In this work, a data-driven meal bolus decision method is proposed without the need of subject-specific glucose management…
A goal of systems biology is to understand the dynamics of intracellular systems. Stochastic chemical kinetic models are often utilized to accurately capture the stochastic nature of these systems due to low numbers of molecules. Collecting…
Radiologists can classify a mammogram as normal or abnormal at better than chance levels after less than a second's exposure to the images. In this work, we combine these radiologists' gist inputs into pre-trained machine learning models to…
The number of studies on deep learning for medical diagnosis is expanding, and these systems are often claimed to outperform clinicians. However, only a few systems have shown medical efficacy. From this perspective, we examine a wide range…
Objective: To develop an automatic image normalization algorithm for intensity correction of images from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) acquired by different MRI scanners with various imaging…
In vivo H nuclear magnetic resonance (NMR) spectroscopy is an important tool for performing non-invasive quantitative assessments of brain tumour glucose metabolism. Brain tumours are considered fast-growth tumours because of their high…
The acid-mediated tumor invasion hypothesis proposes that altered glucose metabolism exhibited by the vast majority of tumors leads to increased acid (H+ ion) production which subsequently facilitates tumor invasion [1-3]. The…
The use of automatic systems in the analysis of medical images has proven to be very useful to radiologists, especially in the framework of screening programs, in which radiologists make their first diagnosis on the basis of images only,…
In this paper, we propose a model of the dynamics of the blood glucose level during an Oral Glucose Tolerance Test (OGTT). This dynamic includes the action of insulin and glucagon in the glucose homeostasis process as the reaction of an…
Dose-response prediction in cancer is an active application field in machine learning. Using large libraries of \textit{in-vitro} drug sensitivity screens, the goal is to develop accurate predictive models that can be used to guide…