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Constructing atomic models from cryo-electron microscopy (cryo-EM) maps is a crucial yet intricate task in structural biology. While advancements in deep learning, such as convolutional neural networks (CNNs) and graph neural networks…

Quantitative Methods · Quantitative Biology 2024-11-01 Xin , Ma , Dong Si

Positive-Unlabeled (PU) learning addresses classification problems where only a subset of positive examples is labeled and the remaining data is unlabeled, making explicit negative supervision unavailable. Existing PU methods often rely on…

Machine Learning · Computer Science 2026-01-26 Vasileios Sevetlidis , George Pavlidis , Antonios Gasteratos

Biomedical image segmentation is critical for precise structure delineation and downstream analysis. Traditional methods often struggle with noisy data, while deep learning models such as U-Net have set new benchmarks in segmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Shuo Zhao , Yu Zhou , Jianxu Chen

The CYGNO experiment employs an optical-readout Time Projection Chamber (TPC) to search for rare low-energy interactions using finely resolved scintillation images. While the optical readout provides rich topological information, it…

Discovering the 3D atomic structure of molecules such as proteins and viruses is a fundamental research problem in biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising vision-based technique for structure estimation which…

Computer Vision and Pattern Recognition · Computer Science 2016-11-18 Marcus A. Brubaker , Ali Punjani , David J. Fleet

Positive-unlabeled learning (PU learning) is known as a special case of semi-supervised binary classification where only a fraction of positive examples are labeled. The challenge is then to find the correct classifier despite this lack of…

Statistics Theory · Mathematics 2022-01-19 Olivier Coudray , Christine Keribin , Pascal Massart , Patrick Pamphile

Positive-Unlabeled (PU) learning is an analog to supervised binary classification for the case when only the positive sample is clean, while the negative sample is contaminated with latent instances of positive class and hence can be…

Machine Learning · Computer Science 2020-06-09 Dmitry Ivanov

We consider the situation in which a user has collected a small set of documents on a cohesive topic, and they want to retrieve additional documents on this topic from a large collection. Information Retrieval (IR) solutions treat the…

Computation and Language · Computer Science 2021-01-18 Alon Jacovi , Gang Niu , Yoav Goldberg , Masashi Sugiyama

Weakly supervised semantic segmentation has witnessed great achievements with image-level labels. Several recent approaches use the CLIP model to generate pseudo labels for training an individual segmentation model, while there is no…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Bingfeng Zhang , Siyue Yu , Yunchao Wei , Yao Zhao , Jimin Xiao

Over the last decade, scanning transmission electron microscopy (STEM) has emerged as a powerful tool for probing atomic structures of complex materials with picometer precision, opening the pathway toward exploring ferroelectric,…

Data Analysis, Statistics and Probability · Physics 2021-12-23 Ayana Ghosh , Christopher T. Nelson , Mark Oxley , Xiaohang Zhang , Maxim Ziatdinov , Ichiro Takeuchi , Sergei V. Kalinin

Cellular electron cryo-tomography enables the 3D visualization of cellular organization in the near-native state and at submolecular resolution. However, the contents of cellular tomograms are often complex, making it difficult to…

Quantitative Methods · Quantitative Biology 2017-12-29 Xiangrui Zeng , Miguel Ricardo Leung , Tzviya Zeev-Ben-Mordehai , Min Xu

In this paper, the concept of representation learning based on deep neural networks is applied as an alternative to the use of handcrafted features in a method for automatic visual inspection of corroded thermoelectric metallic pipes. A…

Computer Vision and Pattern Recognition · Computer Science 2019-05-30 Daniel Vriesman , Alessandro Zimmer , Alceu S. Britto , Alessandro L. Koerich

Motivation: Cellular Electron CryoTomography (CECT) enables 3D visualization of cellular organization at near-native state and in sub-molecular resolution, making it a powerful tool for analyzing structures of macromolecular complexes and…

Quantitative Methods · Quantitative Biology 2017-04-14 Min Xu , Xiaoqi Chai , Hariank Muthakana , Xiaodan Liang , Ge Yang , Tzviya Zeev-Ben-Mordehai , Eric Xing

Positive-unlabeled learning (PUL) aims at learning a binary classifier from only positive and unlabeled training data. Even though real-world applications often involve imbalanced datasets where the majority of examples belong to one class,…

Machine Learning · Statistics 2024-03-12 Emilio Dorigatti , Jann Goschenhofer , Benjamin Schubert , Mina Rezaei , Bernd Bischl

Accurate in silico modeling of the antigen processing pathway is crucial to enable personalized epitope vaccine design for cancer. An important step of such pathway is the degradation of the vaccine into smaller peptides by the proteasome,…

Quantitative Methods · Quantitative Biology 2022-10-31 Emilio Dorigatti , Bernd Bischl , Benjamin Schubert

Positive-unlabeled learning refers to the process of training a binary classifier using only positive and unlabeled data. Although unlabeled data can contain positive data, all unlabeled data are regarded as negative data in existing…

Machine Learning · Computer Science 2021-03-09 Daiki Tanaka , Daiki Ikami , Kiyoharu Aizawa

In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer

Recent advances in the synthesis of polar molecular materials have produced practical alternatives to ferroelectric ceramics, opening up exciting new avenues for their incorporation into modern electronic devices. However, in order to…

Quantitative analysis of cell nuclei in microscopic images is an essential yet challenging source of biological and pathological information. The major challenge is accurate detection and segmentation of densely packed nuclei in images…

Quantitative Methods · Quantitative Biology 2019-11-14 Linqing Feng , Jun Ho Song , Jiwon Kim , Soomin Jeong , Jin Sung Park , Jinhyun Kim

Particle tracking is a fundamental task in digital microscopy. Recently, machine-learning approaches have made great strides in overcoming the limitations of more classical approaches. The training of state-of-the-art machine-learning…