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This paper reports on the use of a convolutional neural network (CNN) methodology to analyse fluorescence images of calcium-ion Coulomb crystals in the gas phase. A transfer-learning approach is adopted using the publicly available RESNET50…

Calcium imaging has become a fundamental neural imaging technique, aiming to recover the individual activity of hundreds of neurons in a cortical region. Current methods (mostly matrix factorization) are aimed at detecting neurons in the…

Applications · Statistics 2019-02-11 Gal Mishne , Adam S. Charles

Calcium imaging is one of the most important tools in neurophysiology as it enables the observation of neuronal activity for hundreds of cells in parallel and at single-cell resolution. In order to use the data gained with calcium imaging,…

Neurons and Cognition · Quantitative Biology 2020-04-07 Elke Kirschbaum , Alberto Bailoni , Fred A. Hamprecht

Neurons encode information about the environment through their activity. As animals explore the environment, neurons rapidly acquire selectivity for distinct features of the external world; characterizing how these selectivity patterns…

Calcium imaging allows for the parallel measurement of large neuronal populations in a spatially resolved and minimally invasive manner, and has become a gold-standard for neuronal functionality. While deep generative models have been…

Neurons and Cognition · Quantitative Biology 2025-10-02 Berta Ros , Mireia Olives-Verger , Caterina Fuses , Josep M Canals , Jordi Soriano , Jordi Abante

Visual saliency detection aims at identifying the most visually distinctive parts in an image, and serves as a pre-processing step for a variety of computer vision and image processing tasks. To this end, the saliency detection procedure…

Computer Vision and Pattern Recognition · Computer Science 2017-02-27 Xuanyang Xi , Yongkang Luo , Fengfu Li , Peng Wang , Hong Qiao

With the rapid growth of neuroimaging technologies, a great effort has been dedicated recently to investigate the dynamic changes in brain activity. Examples include time course calcium imaging and dynamic brain functional connectivity. In…

Methodology · Statistics 2020-08-31 Wei Hu , Tianyu Pan , Dehan Kong , Weining Shen

Creating datasets for Neuromorphic Vision is a challenging task. A lack of available recordings from Neuromorphic Vision sensors means that data must typically be recorded specifically for dataset creation rather than collecting and…

Databases · Computer Science 2015-10-20 Garrick Orchard , Ajinkya Jayawant , Gregory Cohen , Nitish Thakor

Neural recordings, returns from radars and sonars, images in astronomy and single-molecule microscopy can be modeled as a linear superposition of a small number of scaled and delayed copies of a band-limited or diffraction-limited point…

Information Theory · Computer Science 2016-05-25 Yuejie Chi

Deducing the structure of neural circuits is one of the central problems of modern neuroscience. Recently-introduced calcium fluorescent imaging methods permit experimentalists to observe network activity in large populations of neurons,…

Applications · Statistics 2011-07-22 Yuriy Mishchencko , Joshua T. Vogelstein , Liam Paninski

We study the question of extracting a sequence of functions $\{\boldsymbol{f}_i, \boldsymbol{g}_i\}_{i=1}^s$ from observing only the sum of their convolutions, i.e., from $\boldsymbol{y} = \sum_{i=1}^s \boldsymbol{f}_i\ast…

Information Theory · Computer Science 2017-11-29 Shuyang Ling , Thomas Strohmer

In this work, we propose a simple yet effective solution to the problem of connectome inference in calcium imaging data. The proposed algorithm consists of two steps. First, processing the raw signals to detect neural peak activities.…

We propose a deconvolution algorithm for images blurred and degraded by a Poisson noise. The algorithm uses a fast proximal backward-forward splitting iteration. This iteration minimizes an energy which combines a \textit{non-linear} data…

Applications · Statistics 2008-12-18 François-Xavier Dupé , Jalal Fadili , Jean Luc Starck

We study noisy calcium imaging data, with a focus on the classification of spike traces. As raw traces obscure the true temporal structure of neuron's activity, we performed a tuned filtering of the calcium concentration using two methods:…

Neurons and Cognition · Quantitative Biology 2024-09-17 Arianna Burzacchi , Nicoletta D'Angelo , David Payares-Garcia , Jorge Mateu

As the availability of imagery data continues to swell, so do the demands on transmission, storage and processing power. Processing requirements to handle this plethora of data is quickly outpacing the utility of conventional processing…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Artyom M. Grigoryan , Sos S. Agaian , Karen Panetta

Ultra-low power local signal processing is a crucial aspect for edge applications on always-on devices. Neuromorphic processors emulating spiking neural networks show great computational power while fulfilling the limited power budget as…

Machine Learning · Computer Science 2021-11-03 Philipp Weidel , Sadique Sheik

Confocal laser-scanning microscopy (CLSM) is one of the most popular optical architectures for fluorescence imaging. In CLSM, a focused laser beam excites the fluorescence emission from a specific specimen position. Some actuators scan the…

Image and Video Processing · Electrical Eng. & Systems 2023-05-10 Alessandro Zunino , Marco Castello , Giuseppe Vicidomini

High-speed optical imaging of dynamic neuronal activity is essential yet challenging in neuroscience. While calcium imaging has been firmly established as a workhorse technique for monitoring neuronal activity, its limited temporal…

Blind deconvolution is a challenging problem, but in low-light it is even more difficult. Existing algorithms, both classical and deep-learning based, are not designed for this condition. When the photon shot noise is strong, conventional…

Image and Video Processing · Electrical Eng. & Systems 2022-11-21 Yash Sanghvi , Abhiram Gnanasambandam , Zhiyuan Mao , Stanley H. Chan

In this paper, we propose a novel design of image deblurring in the form of one-shot convolution filtering that can directly convolve with naturally blurred images for restoration. The problem of optical blurring is a common disadvantage to…

Image and Video Processing · Electrical Eng. & Systems 2019-07-22 Mahdi S. Hosseini , Konstantinos N. Plataniotis