Related papers: Sources of Variance in Two-Photon Microscopy Neuro…
The glow of a starry night sky, the smell of a freshly brewed cup of coffee or the sound of ocean waves breaking on the beach are representations of the physical world that have been created by the dynamic interactions of thousands of…
Neural systems can be modeled as networks of functionally connected neural elements. The resulting network can be analyzed using mathematical tools from network science and graph theory to quantify the system's topological organization and…
Over the past decade, techniques enabling bidirectional modulation of neuronal activity with single cell precision have rapidly advanced in the form of two-photon optogenetic stimulation. Unlike conventional electrophysiological approaches…
Two-photon imaging of calcium indicators allows simultaneous recording of responses of hundreds of neurons over hours and even days, but provides a relatively indirect measure of their spiking activity. Existing deconvolution algorithms…
Multi-photon emitters are a sought-after resource in quantum photonics. Nonlinear interactions between a multi-level atomic system and a coherent drive can lead to resonant two-photon emission, but harvesting light from this process has…
Coherent control is extended to macroscopic processes under continuous pulsed laser irradiation. Here, this approach is used to analyze the experimentally measured two-photon phase control of currents emanating from a living brain cells…
The interferometer is one of the most important devices for revealing the nature of light and for precision optical metrology. Though lots of experiments were performed for probing photons behaviors in various configurations, a complete…
Light-sheet fluorescence microscopy (LSFM) enables real-time whole-brain functional imaging in zebrafish larvae. Conventional one photon LSFM can however induce undesirable visual stimulation due to the use of visible excitation light. The…
A modified double slit experiment of light was implemented. In the experiment, a spatial shape filter is used to manipulate the shape of cross section of laser beam. When this modified laser beam was shined on the double slit, the intensity…
High-speed optical imaging of dynamic neuronal activity is essential yet challenging in neuroscience. While calcium imaging has been firmly established as a workhorse technique for monitoring neuronal activity, its limited temporal…
Neuroimaging has profoundly enhanced our understanding of the human brain by characterizing its structure, function, and connectivity through modalities like MRI, fMRI, EEG, and PET. These technologies have enabled major breakthroughs…
Double-slits provide incoming photons with a choice. Those that survive the passage have chosen from two possible paths which interfere to distribute them in a wave-like manner. Such wave-particle duality continues to be challenged and…
Conventional visualization media such as MRI prints and computer screens are inherently two dimensional, making them incapable of displaying true 3D volume data sets. By applying only transparency or intensity projection, and ignoring…
A major open challenge in neuroscience is the ability to measure and perturb neural activity in vivo from well-defined neural sub-populations at cellular resolution anywhere in the brain. However, limitations posed by scattering and…
We demonstrate fluorescence imaging by two-photon excitation without scanning in biological specimens as previously described by Hwang and co-workers, but with an increased field size and with framing rates of up to 100 Hz. During…
The intricate nature of the brain necessitates the application of advanced probing techniques to comprehensively study and understand its working mechanisms. Neurophotonics offers minimally invasive methods to probe the brain using optics…
The mammalian brain is a densely interconnected network that consists of millions to billions of neurons. Decoding how information is represented and processed by this neural circuitry requires the ability to capture and manipulate the…
A number of questions in systems biology such as understanding how dynamics of neuronal networks are related to brain function require the ability to capture the functional dynamics of large cellular populations at high speed. Recently,…
Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be…
The purpose of this paper is to study the interaction between a two-level system and two continuous-mode photons. Two scenarios are investigated: Case 1, how a two-level system changes the pulse shapes of two input photons propagating in a…