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Splice sites play a crucial role in gene expression, and accurate prediction of these sites in DNA sequences is essential for diagnosing and treating genetic disorders. We address the challenge of splice site prediction by introducing…

Genomics · Quantitative Biology 2023-11-23 Asmita Poddar , Vladimir Uzun , Elizabeth Tunbridge , Wilfried Haerty , Alejo Nevado-Holgado

Change detection (CD) is an essential earth observation technique. It captures the dynamic information of land objects. With the rise of deep learning, convolutional neural networks (CNN) have shown great potential in CD. However, current…

Image and Video Processing · Electrical Eng. & Systems 2022-12-13 Hongjia Chen , Fangling Pu , Rui Yang , Rui Tang , Xin Xu

Background: The expanding research in the field of long non-coding RNAs(lncRNAs) showed abnormal expression of lncRNAs in many complex diseases. Accurately identifying lncRNA-disease association is essential in understanding lncRNA…

Quantitative Methods · Quantitative Biology 2020-06-24 Manu Madhavan , Gopakumar G

Computational approaches to drug discovery can reduce the time and cost associated with experimental assays and enable the screening of novel chemotypes. Structure-based drug design methods rely on scoring functions to rank and predict…

Machine Learning · Statistics 2020-10-19 Matthew Ragoza , Joshua Hochuli , Elisa Idrobo , Jocelyn Sunseri , David Ryan Koes

Predicting DNA-protein binding is an important and classic problem in bioinformatics. Convolutional neural networks have outperformed conventional methods in modeling the sequence specificity of DNA-protein binding. However, none of the…

Genomics · Quantitative Biology 2021-06-04 Yuhang Guo , Xiao Luo , Liang Chen , Minghua Deng

Protein interactions are important in a broad range of biological processes. Traditionally, computational methods have been developed to automatically predict protein interface from hand-crafted features. Recent approaches employ deep…

Machine Learning · Computer Science 2020-07-21 Yi Liu , Hao Yuan , Lei Cai , Shuiwang Ji

Structure based ligand discovery is one of the most successful approaches for augmenting the drug discovery process. Currently, there is a notable shift towards machine learning (ML) methodologies to aid such procedures. Deep learning has…

Machine Learning · Statistics 2018-06-12 Marta M. Stepniewska-Dziubinska , Piotr Zielenkiewicz , Pawel Siedlecki

As high-throughput biological sequencing becomes faster and cheaper, the need to extract useful information from sequencing becomes ever more paramount, often limited by low-throughput experimental characterizations. For proteins, accurate…

Quantitative Methods · Quantitative Biology 2017-01-31 Xueliang Liu

Due to the lack of a method to efficiently represent the multimodal information of a protein, including its structure and sequence information, predicting compound-protein binding affinity (CPA) still suffers from low accuracy when applying…

Biomolecules · Quantitative Biology 2022-11-28 Binjie Guo , Hanyu Zheng , Haohan Jiang , Xiaodan Li , Naiyu Guan , Yanming Zuo , Yicheng Zhang , Hengfu Yang , Xuhua Wang

Predictive monitoring of business processes is a subfield of process mining that aims to predict, among other things, the characteristics of the next event or the sequence of next events. Although multiple approaches based on deep learning…

Machine Learning · Computer Science 2021-12-24 Efrén Rama-Maneiro , Juan C. Vidal , Manuel Lama

Deep convolutional neural networks (DCNNs) are an influential tool for solving various problems in the machine learning and computer vision fields. In this paper, we introduce a new deep learning model called an Inception- Recurrent…

Computer Vision and Pattern Recognition · Computer Science 2017-04-26 Md Zahangir Alom , Mahmudul Hasan , Chris Yakopcic , Tarek M. Taha

The prevalence of employing attention mechanisms has brought along concerns on the interpretability of attention distributions. Although it provides insights about how a model is operating, utilizing attention as the explanation of model…

Computer Vision and Pattern Recognition · Computer Science 2022-09-16 Tristan Gomez , Suiyi Ling , Thomas Fréour , Harold Mouchère

Random backpropagation (RBP) is a variant of the backpropagation algorithm for training neural networks, where the transpose of the forward matrices are replaced by fixed random matrices in the calculation of the weight updates. It is…

Machine Learning · Computer Science 2017-12-25 Pierre Baldi , Peter Sadowski , Zhiqin Lu

The recurrent neural networks (RNN) can be used to solve the sequence to sequence problem, where both the input and the output have sequential structures. Usually there are some implicit relations between the structures. However, it is hard…

Computer Vision and Pattern Recognition · Computer Science 2016-01-27 Feng Wang , David M. J. Tax

The anatomical location of imaging features is of crucial importance for accurate diagnosis in many medical tasks. Convolutional neural networks (CNN) have had huge successes in computer vision, but they lack the natural ability to…

Computer Vision and Pattern Recognition · Computer Science 2016-11-01 Mohsen Ghafoorian , Nico Karssemeijer , Tom Heskes , Inge van Uden , Clara Sanchez , Geert Litjens , Frank-Erik de Leeuw , Bram van Ginneken , Elena Marchiori , Bram Platel

One of the methods used in image recognition is the Deep Convolutional Neural Network (DCNN). DCNN is a model in which the expressive power of features is greatly improved by deepening the hidden layer of CNN. The architecture of CNNs is…

Computer Vision and Pattern Recognition · Computer Science 2020-07-10 Genta Kobayashi , Hayaru Shouno

Motivation: Receptor-binding proteins (RBPs) initiate viral infection and determine host specificity, serving as key targets for phage engineering and therapy. However, the identification of RBPs is complicated by their extreme sequence…

Genomics · Quantitative Biology 2026-03-17 Xiling Luo , Le Ou-Yang , Yang Shen , Jiaojiao Guan , Dehan Cai , Jun Zhang , Yanni Sun , Jiayu Shang

Although deep convolutional networks have been widely studied for head and neck (HN) organs at risk (OAR) segmentation, their use for routine clinical treatment planning is limited by a lack of robustness to imaging artifacts, low soft…

Computer Vision and Pattern Recognition · Computer Science 2021-03-01 Harini Veeraraghavan , Jue Jiang , Sharif Elguindi , Sean L. Berry , Ifeanyirochukwu Onochie , Aditya Apte , Laura Cervino , Joseph O. Deasy

Attention-based neural networks, such as Transformers, have become ubiquitous in numerous applications, including computer vision, natural language processing, and time-series analysis. In all kinds of attention networks, the attention maps…

Machine Learning · Computer Science 2023-05-01 Yujing Wang , Yaming Yang , Zhuo Li , Jiangang Bai , Mingliang Zhang , Xiangtai Li , Jing Yu , Ce Zhang , Gao Huang , Yunhai Tong

Attention Branch Networks (ABNs) have been shown to simultaneously provide visual explanation and improve the performance of deep convolutional neural networks (CNNs). In this work, we introduce Multi-Scale Attention Branch Networks…

Computer Vision and Pattern Recognition · Computer Science 2023-06-28 Ankit Gupta , Ida-Maria Sintorn
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