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Precision medicine seeks to discover an optimal personalized treatment plan and thereby provide informed and principled decision support, based on the characteristics of individual patients. With recent advancements in medical imaging, it…

Methodology · Statistics 2023-04-26 Xinyi Li , Michael R. Kosorok

We study the problem of a decision maker who must provide the best possible treatment recommendation based on an experiment. The desirability of the outcome distribution resulting from the policy recommendation is measured through a…

Econometrics · Economics 2022-04-06 Anders Bredahl Kock , David Preinerstorfer , Bezirgen Veliyev

Causal decomposition analysis provides a way to identify mediators that contribute to health disparities between marginalized and non-marginalized groups. In particular, the degree to which a disparity would be reduced or remain after…

Methodology · Statistics 2021-09-16 Soojin Park , Suyeon Kang , Chioun Lee

We study the problem of learning to choose from m discrete treatment options (e.g., news item or medical drug) the one with best causal effect for a particular instance (e.g., user or patient) where the training data consists of passive…

Machine Learning · Statistics 2017-08-02 Nathan Kallus

The article deals with the issue of modification of metric classification algorithms. In particular, it studies the algorithm k-Nearest Neighbours for its application to sequential data. A method of generalization of metric classification…

Machine Learning · Computer Science 2016-12-19 Roman Samarev , Andrey Vasnetsov , Elizaveta Smelkova

The interference model has been widely used and studied in block experiments where the treatment for a particular plot has effects on its neighbor plots. In this paper, we study optimal circular designs for the proportional interference…

Statistics Theory · Mathematics 2015-07-31 Kang Li , Wei Zheng , Mingyao Ai

This paper investigates the optimal ergodic sublinear convergence rate of the relaxed proximal point algorithm for solving monotone variational inequality problems. The exact worst case convergence rate is computed using the performance…

Optimization and Control · Mathematics 2019-07-15 Guoyong Gu , Junfeng Yang

Identifying causal effects is a key problem of interest across many disciplines. The two long-standing approaches to estimate causal effects are observational and experimental (randomized) studies. Observational studies can suffer from…

Machine Learning · Computer Science 2024-07-09 Sepehr Elahi , Sina Akbari , Jalal Etesami , Negar Kiyavash , Patrick Thiran

Perhaps the most straightforward classifier in the arsenal or machine learning techniques is the Nearest Neighbour Classifier -- classification is achieved by identifying the nearest neighbours to a query example and using those neighbours…

Machine Learning · Computer Science 2021-08-10 Padraig Cunningham , Sarah Jane Delany

The current body of research on developing optimal treatment strategies often places emphasis on intention-to-treat analyses, which fail to take into account the compliance behavior of individuals. Methods based on instrumental variables…

Methodology · Statistics 2024-02-21 Cuong T. Pham , Kevin G. Lynch , James R. McKay , Ashkan Ertefaie

A dynamic treatment regime is a sequence of medical decisions that adapts to the evolving clinical status of a patient over time. To facilitate personalized care, it is crucial to assess the probability of each available treatment option…

Methodology · Statistics 2024-11-05 Jiefeng Bi , Matteo Borrotti , Bernardo Nipoti

Successive quadratic approximations, or second-order proximal methods, are useful for minimizing functions that are a sum of a smooth part and a convex, possibly nonsmooth part that promotes regularization. Most analyses of iteration…

Optimization and Control · Mathematics 2019-01-25 Ching-pei Lee , Stephen J. Wright

Motivated by the mode estimation problem of an unknown multivariate probability density function, we study the problem of identifying the point with the minimum k-th nearest neighbor distance for a given dataset of n points. We study the…

Machine Learning · Statistics 2020-10-27 Anirudh Singhal , Subham Pirojiwala , Nikhil Karamchandani

The problem of scheduling unrelated machines has been studied since the inception of algorithmic mechanism design \cite{NR99}. It is a resource allocation problem that entails assigning $m$ tasks to $n$ machines for execution. Machines are…

Computer Science and Game Theory · Computer Science 2022-04-21 Yansong Gao , Jie Zhang

We investigate approximating joint distributions of random processes with causal dependence tree distributions. Such distributions are particularly useful in providing parsimonious representation when there exists causal dynamics among…

Information Theory · Computer Science 2011-01-27 Christopher J. Quinn , Todd P. Coleman , Negar Kiyavash

We address composite optimization problems, which consist in minimizing the sum of a smooth and a merely lower semicontinuous function, without any convexity assumptions. Numerical solutions of these problems can be obtained by proximal…

Optimization and Control · Mathematics 2024-02-14 Alberto De Marchi

We propose, analyze, and test a proximal-gradient method for solving regularized optimization problems with general constraints. The method employs a decomposition strategy to compute trial steps and uses a merit function to determine step…

Optimization and Control · Mathematics 2026-01-16 Frank E. Curtis , Xiaoyi Qu , Daniel P. Robinson

Metric based comparison operations such as finding maximum, nearest and farthest neighbor are fundamental to studying various clustering techniques such as $k$-center clustering and agglomerative hierarchical clustering. These techniques…

Data Structures and Algorithms · Computer Science 2021-05-13 Raghavendra Addanki , Sainyam Galhotra , Barna Saha

There is an increasing body of evidence suggesting that exact nearest neighbour search in high-dimensional spaces is affected by the curse of dimensionality at a fundamental level. Does it necessarily mean that the same is true for k…

Machine Learning · Statistics 2021-02-18 Vladimir Pestov

Spectral statistics of quantum systems have been studied in detail using the nearest neighbour level spacings, which for generic chaotic systems follows random matrix theory predictions. In this work, the probability density of the closest…

Chaotic Dynamics · Physics 2019-01-23 Shashi C. L. Srivastava , Arul Lakshminarayan , Steven Tomsovic , Arnd Bäcker
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