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Dynamic treatment regimes are sequential decision rules that adapt treatment according to individual time-varying characteristics and outcomes to achieve optimal effects, with applications in precision medicine, personalized…

Methodology · Statistics 2025-10-24 Yuanshan Gao , Yang Bai , Yifan Cui

A common concern when a policymaker draws causal inferences from and makes decisions based on observational data is that the measured covariates are insufficiently rich to account for all sources of confounding, i.e., the standard no…

Methodology · Statistics 2023-10-25 Tao Shen , Yifan Cui

The traditional k nearest neighbor (kNN) approach uses a distance formula within a spherical region to determine the k closest training observations to a test sample point. However, this approach may not work well when test point is located…

Machine Learning · Statistics 2024-02-19 Amjad Ali , Zardad Khan , Dost Muhammad Khan , Saeed Aldahmani

Algorithms often carry out equally many computations for "easy" and "hard" problem instances. In particular, algorithms for finding nearest neighbors typically have the same running time regardless of the particular problem instance. In…

Data Structures and Algorithms · Computer Science 2020-03-25 Daniel LeJeune , Richard G. Baraniuk , Reinhard Heckel

We develop a mathematical framework to define an optimal individualized treatment rule (ITR) within the context of prioritized outcomes in a randomized controlled trial. Our optimality criterion is based on the framework of generalized…

Methodology · Statistics 2025-06-17 François Petit , Gérard Biau , Raphaël Porcher

We study the consistency of the $k$-nearest neighbor regressor under complex survey designs. While consistency results for this algorithm are well established for independent and identically distributed data, corresponding results for…

Machine Learning · Statistics 2026-03-19 Caren Hasler

Treatment effect estimation is of high-importance for both researchers and practitioners across many scientific and industrial domains. The abundance of observational data makes them increasingly used by researchers for the estimation of…

Machine Learning · Statistics 2023-06-22 Niki Kiriakidou , Christos Diou

The $k$-nearest neighbor ($k$-NN) algorithm is one of the most popular methods for nonparametric classification. However, a relevant limitation concerns the definition of the number of neighbors $k$. This parameter exerts a direct impact on…

Machine Learning · Computer Science 2024-09-10 Alexandre Luís Magalhães Levada , Frank Nielsen , Michel Ferreira Cardia Haddad

Precision medicine is currently a topic of great interest in clinical and intervention science. One way to formalize precision medicine is through a treatment regime, which is a sequence of decision rules, one per stage of clinical…

Methodology · Statistics 2016-06-07 Yichi Zhang , Eric B. Laber , Anastasios Tsiatis , Marie Davidian

The weighted k-nearest neighbors algorithm is one of the most fundamental non-parametric methods in pattern recognition and machine learning. The question of setting the optimal number of neighbors as well as the optimal weights has…

Machine Learning · Statistics 2017-01-26 Oren Anava , Kfir Y. Levy

Trustworthiness in model predictions is crucial for safety-critical applications in the real world. However, deep neural networks often suffer from the issues of uncertainty estimation, such as miscalibration. In this study, we propose…

Computation and Language · Computer Science 2025-02-07 Wataru Hashimoto , Hidetaka Kamigaito , Taro Watanabe

A dynamic treatment regime is a sequence of treatment decision rules tailored to an individual's evolving status over time. In precision medicine, much focus has been placed on finding an optimal dynamic treatment regime which, if followed…

Other Statistics · Statistics 2025-10-13 Chunyu Wang , Brian DM Tom

Considerable recent work has focused on methods for analyzing experiments which exhibit treatment interference -- that is, when the treatment status of one unit may affect the response of another unit. Such settings are common in…

Methodology · Statistics 2023-07-31 Samirah Alzubaidi , Michael J. Higgins

The k-nearest-neighbor method performs classification tasks for a query sample based on the information contained in its neighborhood. Previous studies into the k-nearest-neighbor algorithm usually achieved the decision value for a class by…

Machine Learning · Computer Science 2018-12-10 Chengsheng Mao , Bin Hu , Lei Chen , Philip Moore , Xiaowei Zhang

Precision medicine involves developing individualized treatment regimes (ITRs) which allow for treatment decisions to be tailored to patient characteristics. Naturally, the identification of the optimal regime, that is, the rule which…

Methodology · Statistics 2025-09-30 Misha Dolmatov , Erica E. M. Moodie , David A. Stephens , Dipankar Bandyopadhyay

A treatment regime is a function that maps individual patient information to a recommended treatment, hence explicitly incorporating the heterogeneity in need for treatment across individuals. Patient responses are dichotomous and can be…

Machine Learning · Statistics 2016-07-07 Yingfei Wang , Warren Powell

Nearest neighbor is a popular class of classification methods with many desirable properties. For a large data set which cannot be loaded into the memory of a single machine due to computation, communication, privacy, or ownership…

Machine Learning · Statistics 2019-11-01 Xingye Qiao , Jiexin Duan , Guang Cheng

The k Nearest Neighbors (kNN) method has received much attention in the past decades, where some theoretical bounds on its performance were identified and where practical optimizations were proposed for making it work fairly well in high…

Machine Learning · Computer Science 2016-06-14 Aleksander Lodwich , Faisal Shafait , Thomas Breuel

k Nearest Neighbor (kNN) method is a simple and popular statistical method for classification and regression. For both classification and regression problems, existing works have shown that, if the distribution of the feature vector has…

Statistics Theory · Mathematics 2019-10-24 Puning Zhao , Lifeng Lai

Nearest neighbor methods are a popular class of nonparametric estimators with several desirable properties, such as adaptivity to different distance scales in different regions of space. Prior work on convergence rates for nearest neighbor…

Machine Learning · Computer Science 2014-07-03 Kamalika Chaudhuri , Sanjoy Dasgupta
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