Related papers: Human Tissues Investigation Using PALS Technique
We present first-principles approaches based on density functional theory for calculating positron states and annihilation characteristics in condensed matter. The treatment of the electron-positron correlation effects (the enhancement of…
New statistical methods were employed to improve the ability to distinguish benign from malignant breast tissue ex vivo in a recent study. The ultimately aim was to improve the intraoperative assessment of positive tumour margins in…
Bound state properties of the negatively charged Ps$^{-}$ ion (or $e^{-} e^{+} e^{-}$) are discussed. The expectation values of operators which correspond to these properties have been determined with the use of the highly accurate wave…
The progression of cancer is associated with different genetic and epigenetic events which result in nano to microscale structural alterations in cells/tissue. However, these structural alterations in the early stage of the disease remain…
Conventional energy filters for x-ray imaging are based on absorbing materials which attenuate low energy photons, sometimes combined with an absorption edge, thus also discriminating towards photons of higher energies. These filters are…
We present a novel method for characterizing mammographic findings using spectral imaging without the use of contrast agent. Within a statistical framework, suspicious findings are analyzed to determine if they are likely to be benign…
Small Angle-X-ray Scattering Tensor Tomography (SAS-TT) is a relatively new, but powerful technique for studying the multiscale architecture of hierarchical structures, which is of particular interest for life science applications.…
Calculations of gamma spectra for positron annihilation on a selection of molecules, including methane and its fluoro-substitutes, ethane, propane, butane and benzene are presented. The annihilation gamma spectra characterise the momentum…
Filtering algorithms for high-dimensional nonlinear non-Gaussian partially observed stochastic processes provide access to the likelihood function and hence enable likelihood-based or Bayesian inference for this methodologically challenging…
Spatial proteomics technologies have transformed our understanding of complex tissue architecture in cancer but present unique challenges for computational analysis. Each study uses a different marker panel and protocol, and most methods…
Positron lifetime spectra were measured in liquid water at temperatures between 0c and 50c. The long lifetime of ortho-positronium atoms (o-Ps) determined by electron pick-off in molecular substances decreases smoothly by 10% as the…
Background: After its first ex-vivo and in-vivo demonstration, Positronium Lifetime Imaging (PLI) has received considerable interest as a potential new diagnostic biomarker. High sensitivity Positron Emission Tomography (PET) systems are…
Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…
Laser illumination of tissue results in a characteristic fluorescence emission spectrum whose features depend on the type of tissue, viz., healthy, adenoma or malignant. Hence measurement of the fluorescence is potentially a rapid and…
We approach to the ortho-positronium (o-Ps) as a relativistic two-body problem in $2+1$ dimensions in which o-Ps is composed of two-oppositely charged particles interacting via an attractive Coulomb force. In addition to separation of…
Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of…
In this article, I present a novel and computational-efficient approach for treatment-response modeling of tumor progression-free survival (PFS) probability using the physical phenomenon of a quantum particle walking on a one-dimensional…
Ultrasound is the second most used modality in medical imaging. It is cost effective, hazardless, portable and implemented routinely in numerous clinical procedures. Nonetheless, image quality is characterized by granulated appearance, poor…
Currently, a large number of stored tissue samples are unavailable for spectroscopic study without the time consuming and destructive process of paraffin removal. Instead, a structurally sensitive technique, sum frequency generation, and a…
Magnetic bottle Time-of-Flight (ToF) spectrometers can measure the energy spectra of all electrons emitted into a 2$\pi$ sr solid angle simultaneously, greatly reducing data collection time. When the detection of the annihilation gamma…