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The growing interest in human-grade total body positron emission tomography (PET) systems has also application in small animal research. Due to the existing limitations in human-based studies involving drug development and novel treatment…

Learning to segmentation without large-scale samples is an inherent capability of human. Recently, Segment Anything Model (SAM) performs the significant zero-shot image segmentation, attracting considerable attention from the computer…

Image and Video Processing · Electrical Eng. & Systems 2023-12-22 Chuanfei Hu , Tianyi Xia , Shenghong Ju , Xinde Li

Pathology is the study of microscopic inspection of tissue, and a pathology diagnosis is often the medical gold standard to diagnose disease. Pathology images provide a unique challenge for computer-vision-based analysis: a single pathology…

Purpose: Proton vertebral body sparing craniospinal irradiation (VBS CSI) treats the thecal sac while avoiding the anterior vertebral bodies in effort to reduce myelosuppression and growth inhibition. However, robust treatment planning…

Spectral imaging is a method in medical x-ray imaging to extract information about the object constituents by the material-specific energy dependence of x-ray attenuation. Contrast-enhanced spectral imaging has been thoroughly investigated,…

Medical Physics · Physics 2021-01-26 Erik Fredenberg , Magnus Aslund , Bjorn Cederstrom , Mats Lundqvist , Mats Danielsson

In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a side effect after the irradiation of healthy tissues and organs…

The space-borne antimatter experiment PAMELA has recently reported a surprising rise in the positron to electron ratio at high energies. It has also recently been found that electromagnetic radiative corrections in some cases may boost the…

Astrophysics · Physics 2010-04-06 Lars Bergstrom , Torsten Bringmann , Joakim Edsjo

Tissue biopsy evaluation in the clinic is in need of quantitative disease markers for diagnosis and, most importantly, prognosis. Among the new technologies, quantitative phase imaging (QPI) has demonstrated promise for histopathology…

The excesses in the electron and positron spectra observed by many experiments, such as PAMELA and AMS-02, have sparked significant theoretical investigation. It is not easy to distinguish the two primary hypotheses dark matter…

High Energy Astrophysical Phenomena · Physics 2024-11-07 Xing-Jian Lv , Xiao-Jun Bi , Kun Fang , Peng-Fei Yin , Meng-Jie Zhao

A key focus in current cancer research is the discovery of cancer biomarkers that allow earlier detection with high accuracy and lower costs for both patients and hospitals. Blood samples have long been used as a health status indicator,…

Genomics · Quantitative Biology 2018-12-24 Xi Chen , Jin Xie , Qingcong Yuan

We developed simulation methodology to assess eventual therapeutic efficiency of exogenous multiparametric changes in a four-component cellular system described by the system of ordinary differential equations. The method is numerically…

Tissues and Organs · Quantitative Biology 2018-06-05 Denis Horváth , Branislav Brutovsky

While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for precision oncology. Here, we present PAST, a pan-cancer…

Quantitative Methods · Quantitative Biology 2025-07-10 Changchun Yang , Haoyang Li , Yushuai Wu , Yilan Zhang , Yifeng Jiao , Yu Zhang , Rihan Huang , Yuan Cheng , Yuan Qi , Xin Guo , Xin Gao

In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-shifting interferometer, built onto a phase-contrast microscope, with white-light illumination. As one of the most sensitive quantitative phase…

Optics · Physics 2020-12-17 Xi Chen , Mikhail E. Kandel , Gabriel Popescu

The distribution of produced isotopes during proton therapy can be imaged with Positron Emission Tomography (PET) to verify dose delivery. However, biological washout, driven by tissue-dependent processes such as perfusion and cellular…

In the article by Ma~\emph{et al.}~[Phys.~Rev.~A {\bf 94}, 052709 (2016)], $\gamma$-ray spectra for positron annihilation on molecules were calculated in the independent-particle approximation with the positron wavefunction set to unity.…

Atomic Physics · Physics 2017-03-22 D. G. Green , G. F. Gribakin

In outside the body HIFU treatment that focused ultrasound beams hit severely with cancer tissue layer especially the soft one, at the time of passage of the body different layers as long as they want to reach tumor, put their own way…

We present measurements and theoretical modeling demonstrating the capability of Doppler Broadened annihilation gamma Spectroscopy (DBS) to provide element-specific information from the topmost atomic layer of surfaces that are either clean…

Mechanical strain and stress play a major role in biological processes such as wound healing or morphogenesis. To assess this role quantitatively, fixed or live images of tissues are acquired at a cellular precision in large fields of…

Tissues and Organs · Quantitative Biology 2019-06-12 M. Durande , S. Tlili , T. Homan , B. Guirao , F. Graner , H. Delanoë-Ayari

Particle beams focused to micrometer-sized spots play a crucial role in forefront research using low-energy positrons. Their expedient and wide application, however, requires highly-resolved, fast beam diagnostics. We have developed two…

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