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Herbal compounds present complex toxicity profiles that are often influenced by both intrinsic chemical properties and pharmacokinetics (PK) governing absorption and clearance. In this study, we develop a quantum regression model to predict…

Quantitative Methods · Quantitative Biology 2025-06-26 Don Roosan , Saif Nirzhor , Rubayat Khan

In this paper, we propose a very concise deep learning approach for collaborative filtering that jointly models distributional representation for users and items. The proposed framework obtains better performance when compared against…

Information Retrieval · Computer Science 2015-02-17 Zhang Junlin , Cai Heng , Huang Tongwen , Xue Huiping

In this paper, we propose a novel self-supervised transfer learning method called \underline{\textbf{D}}istribution \underline{\textbf{M}}atching (DM), which drives the representation distribution toward a predefined reference distribution…

Machine Learning · Statistics 2025-07-03 Yuling Jiao , Wensen Ma , Defeng Sun , Hansheng Wang , Yang Wang

Medical imaging studies have collected high dimensional imaging data to identify imaging biomarkers for diagnosis, screening, and prognosis, among many others. These imaging data are often represented in the form of a multi-dimensional…

Applications · Statistics 2017-11-09 Michelle F. Miranda , Hongtu Zhu , Joseph G. Ibrahim

Syndrome differentiation in Traditional Chinese Medicine (TCM) is the process of understanding and reasoning body condition, which is the essential step and premise of effective treatments. However, due to its complexity and lack of…

Machine Learning · Computer Science 2019-01-23 Zeyuan Wang , Josiah Poon , Shiding Sun , Simon Poon

We introduce Chunk-Distilled Language Modeling (CD-LM), an approach to text generation that addresses two challenges in current large language models (LLMs): the inefficiency of token-level generation, and the difficulty of adapting to new…

Computation and Language · Computer Science 2025-01-03 Yanhong Li , Karen Livescu , Jiawei Zhou

Text retrieval is a long-standing research topic on information seeking, where a system is required to return relevant information resources to user's queries in natural language. From classic retrieval methods to learning-based ranking…

Information Retrieval · Computer Science 2022-11-29 Wayne Xin Zhao , Jing Liu , Ruiyang Ren , Ji-Rong Wen

Relevance modeling between queries and items stands as a pivotal component in commercial search engines, directly affecting the user experience. Given the remarkable achievements of large language models (LLMs) in various natural language…

Artificial Intelligence · Computer Science 2025-02-19 Kaixin Wu , Yixin Ji , Zeyuan Chen , Qiang Wang , Cunxiang Wang , Hong Liu , Baijun Ji , Jia Xu , Zhongyi Liu , Jinjie Gu , Yuan Zhou , Linjian Mo

Extracting medication names from handwritten doctor prescriptions is challenging due to the wide variability in handwriting styles and prescription formats. This paper presents a robust method for extracting medicine names using a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-25 Usman Ali , Sahil Ranmbail , Muhammad Nadeem , Hamid Ishfaq , Muhammad Umer Ramzan , Waqas Ali

Understanding how chemical perturbations propagate through biological systems is essential for robust molecular property prediction. While most existing methods focus on chemical structures alone, recent advances highlight the crucial role…

Machine Learning · Computer Science 2025-11-27 Mengran Li , Zelin Zang , Wenbin Xing , Junzhou Chen , Ronghui Zhang , Jiebo Luo , Stan Z. Li

Huge volumes of patient queries are daily generated on online health forums, rendering manual doctor allocation a labor-intensive task. To better help patients, this paper studies a novel task of doctor recommendation to enable automatic…

Computation and Language · Computer Science 2022-03-15 Xiaoxin Lu , Yubo Zhang , Jing Li , Shi Zong

Medication recommendation aims to integrate patients' long-term health records to provide accurate and safe medication combinations for specific health states. Existing methods often fail to deeply explore the true causal relationships…

Information Retrieval · Computer Science 2024-10-31 Shunpan Liang , Xiang Li , Shi Mu , Chen Li , Yu Lei , Yulei Hou , Tengfei Ma

Medical image analysis using supervised deep learning methods remains problematic because of the reliance of deep learning methods on large amounts of labelled training data. Although medical imaging data repositories continue to expand…

Computer Vision and Pattern Recognition · Computer Science 2019-06-11 Euijoon Ahn , Ashnil Kumar , Dagan Feng , Michael Fulham , Jinman Kim

Drug-target interaction (DTI) prediction plays a crucial role in drug discovery, and deep learning approaches have achieved state-of-the-art performance in this field. We introduce an ensemble of deep learning models (EnsembleDLM) for DTI…

Biomolecules · Quantitative Biology 2022-01-19 Po-Yu Kao , Shu-Min Kao , Nan-Lan Huang , Yen-Chu Lin

Large Language Models (LLMs) enable a new form of digital experimentation where treatments combine human and model-generated content in increasingly sophisticated ways. The main methodological challenge in this setting is representing these…

Methodology · Statistics 2025-10-27 Lei Shi , David Arbour , Raghavendra Addanki , Ritwik Sinha , Avi Feller

Cancer claims millions of lives yearly worldwide. While many therapies have been made available in recent years, by in large cancer remains unsolved. Exploiting computational predictive models to study and treat cancer holds great promise…

Quantitative Methods · Quantitative Biology 2022-11-22 Alexander Partin , Thomas S. Brettin , Yitan Zhu , Oleksandr Narykov , Austin Clyde , Jamie Overbeek , Rick L. Stevens

One essential task in information extraction from the medical corpus is drug name recognition. Compared with text sources come from other domains, the medical text is special and has unique characteristics. In addition, the medical text…

Computation and Language · Computer Science 2016-10-07 Sadikin Mujiono , Mohamad Ivan Fanany , Chan Basaruddin

Distributed representations of words learned from text have proved to be successful in various natural language processing tasks in recent times. While some methods represent words as vectors computed from text using predictive model…

Computation and Language · Computer Science 2018-02-20 Abhik Jana , Pawan Goyal

We present a systematic study of medical-domain interpretability in Large Language Models (LLMs). We study how the LLMs both represent and process medical knowledge through four different interpretability techniques: (1) UMAP projections of…

Machine Learning · Computer Science 2026-02-24 Razvan Marinescu , Victoria-Elisabeth Gruber , Diego Fajardo

Deep learning models have become fundamental tools in drug design. In particular, large language models trained on biochemical sequences learn feature vectors that guide drug discovery through virtual screening. However, such models do not…

Biomolecules · Quantitative Biology 2025-03-28 Joseph D. Clark , Tanner J. Dean , Diwakar Shukla