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Large Language Models (LLMs) have achieved remarkable success in various fields, prompting several studies to explore their potential in recommendation systems. However, these attempts have so far resulted in only modest improvements over…

Information Retrieval · Computer Science 2024-09-20 Junyi Chen , Lu Chi , Bingyue Peng , Zehuan Yuan

A pharmacological effect of a drug on cells, organs and systems refers to the specific biochemical interaction produced by a drug substance, which is called its mechanism of action. Drug repositioning (or drug repurposing) is a fundamental…

Machine Learning · Computer Science 2020-05-19 Dehua Chen , Amir Jalilifard , Adriano Veloso , Nivio Ziviani

The quality of machine learning models depends heavily on their training data. Selecting high-quality, diverse training sets for large language models (LLMs) is a difficult task, due to the lack of cheap and reliable quality metrics. While…

Machine Learning · Computer Science 2026-01-30 Robert Istvan Busa-Fekete , Julian Zimmert , Anne Xiangyi Zheng , Claudio Gentile , Andras Gyorgy

Clinical trials need to recruit a sufficient number of volunteer patients to demonstrate the statistical power of the treatment (e.g., a new drug) in curing a certain disease. Clinical trial recruitment has a significant impact on trial…

Machine Learning · Computer Science 2024-07-19 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

Federated medical relation extraction enables multiple clients to train a deep network collaboratively without sharing their raw medical data. In order to handle the heterogeneous label distribution across clients, most of the existing…

Artificial Intelligence · Computer Science 2023-01-16 Chunhui Du , Hao He , Yaohui Jin

Semi-supervised learning is a promising way to reduce the annotation cost for text-classification. Combining with pre-trained language models (PLMs), e.g., BERT, recent semi-supervised learning methods achieved impressive performance. In…

Computation and Language · Computer Science 2022-05-23 Hai-Ming Xu , Lingqiao Liu , Ehsan Abbasnejad

The appearance of a new dangerous and contagious disease requires the development of a drug therapy faster than what is foreseen by usual mechanisms. Many drug therapy developments consist in investigating through different clinical trials…

Quantitative Methods · Quantitative Biology 2020-03-31 Ezequiel Alvarez , Federico Lamagna , Manuel Szewc

Recent progress in Multimodal Large Language Models (MLLMs) have significantly enhanced the ability of artificial intelligence systems to understand and generate multimodal content. However, these models often exhibit limited effectiveness…

Multimedia · Computer Science 2025-12-03 Pengju Xu , Yan Wang , Shuyuan Zhang , Xuan Zhou , Xin Li , Yue Yuan , Fengzhao Li , Shunyuan Zhou , Xingyu Wang , Yi Zhang , Haiying Zhao

Distributed language representation has become the most widely used technique for language representation in various natural language processing tasks. Most of the natural language processing models that are based on deep learning…

Computation and Language · Computer Science 2020-05-11 Martina Toshevska , Frosina Stojanovska , Jovan Kalajdjieski

The practice of fine-tuning Pre-trained Language Models (PLMs) from general or domain-specific data to a specific task with limited resources, has gained popularity within the field of natural language processing (NLP). In this work, we…

Computation and Language · Computer Science 2023-10-31 Samuel Belkadi , Lifeng Han , Yuping Wu , Goran Nenadic

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

Extracting structured medical insights from unstructured clinical text using Natural Language Processing (NLP) remains an open challenge in healthcare, particularly in non-English contexts where resources are scarce. This study presents a…

Artificial Intelligence · Computer Science 2025-11-21 Paulina Tworek , Miłosz Bargieł , Yousef Khan , Tomasz Pełech-Pilichowski , Marek Mikołajczyk , Roman Lewandowski , Jose Sousa

Large Language Models (LLMs) have shown promise in clinical applications through prompt engineering, allowing flexible clinical predictions. However, they struggle to produce reliable prediction probabilities, which are crucial for…

Artificial Intelligence · Computer Science 2024-12-05 Bowen Gu , Rishi J. Desai , Kueiyu Joshua Lin , Jie Yang

Large language models (LLMs) have shown strong ability in generating rich representations across domains such as natural language processing and generation, computer vision, and multimodal learning. However, their application in biomedical…

Genomics · Quantitative Biology 2025-09-30 Luxuan Zhang , Douglas Jiang , Qinglong Wang , Haoqi Sun , Feng Tian

Recently, the performance of Pre-trained Language Models (PLMs) has been significantly improved by injecting knowledge facts to enhance their abilities of language understanding. For medical domains, the background knowledge sources are…

Computation and Language · Computer Science 2021-08-23 Taolin Zhang , Zerui Cai , Chengyu Wang , Minghui Qiu , Bite Yang , Xiaofeng He

In this work, an ontology-based model for AI-assisted medicine side-effect (SE) prediction is developed, where three main components, including the drug model, the treatment model, and the AI-assisted prediction model, of proposed model are…

Artificial Intelligence · Computer Science 2019-10-02 Yuanzhe Yao , Zeheng Wang , Liang Li , Kun Lu , Runyu Liu , Zhiyuan Liu , Jing Yan

Many efforts have been made to facilitate natural language processing tasks with pre-trained language models (LMs), and brought significant improvements to various applications. To fully leverage the nearly unlimited corpora and capture…

Computation and Language · Computer Science 2018-09-11 Liyuan Liu , Xiang Ren , Jingbo Shang , Jian Peng , Jiawei Han

Classifiers are an important and defining feature of the Chinese language, and their correct prediction is key to numerous educational applications. Yet, whether the most popular Large Language Models (LLMs) possess proper knowledge the…

Computation and Language · Computer Science 2025-11-04 Ziqi Zhang , Jianfei Ma , Emmanuele Chersoni , Jieshun You , Zhaoxin Feng

Understanding human preferences is crucial for improving foundation models and building personalized AI systems. However, preferences are inherently diverse and complex, making it difficult for traditional reward models to capture their…

Artificial Intelligence · Computer Science 2025-06-12 Feng Luo , Rui Yang , Hao Sun , Chunyuan Deng , Jiarui Yao , Jingyan Shen , Huan Zhang , Hanjie Chen

The evaluation of large language models (LLMs) has drawn substantial attention in the field recently. This work focuses on evaluating LLMs in a Chinese context, specifically, for Traditional Chinese which has been largely underrepresented…

Computation and Language · Computer Science 2024-04-01 Po-Heng Chen , Sijia Cheng , Wei-Lin Chen , Yen-Ting Lin , Yun-Nung Chen
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