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The formation of a collectively moving group benefits individuals within a population in a variety of ways such as ultra-sensitivity to perturbation, collective modes of feeding, and protection from environmental stress. While some…

Biological Physics · Physics 2014-10-28 Shashi Thutupalli , Mingzhai Sun , Filiz Bunyak , Kannappan Palaniappan , Joshua. W. Shaevitz

The bacterium Myxoccocus xanthus produces multicellular protective droplets called fruiting bodies when starved. These structures form initially through the active dewetting of cells into surface-bound droplets, where substantial flows of…

Biological Physics · Physics 2021-11-25 Matthew E. Black , Joshua W. Shaevitz

Colonies of the social bacterium Myxococcus xanthus go through a morphological transition from a thin colony of cells to three-dimensional droplet-like fruiting bodies as a strategy to survive starvation. The biological pathways that…

Myxococcus xanthus is a unicellular organism whose cells possess the ability to move and communicate, leading to the emergence of complex collective properties and behaviours. This has made it an ideal model system to study the emergence of…

Formation of spatial patterns of cells is a recurring theme in biology and often depends on regulated cell motility. Motility of M. xanthus depends on two motility machineries: the S-engine and A-engine. Moving M. xanthus cells can organize…

The soil bacterium Myxococcus xanthus lives in densely packed groups that form dynamic three-dimensional patterns in response to environmental changes, such as droplet-like fruiting bodies during starvation. The development of these…

Biological Physics · Physics 2021-05-26 Katherine Copenhagen , Ricard Alert , Ned S. Wingreen , Joshua W. Shaevitz

Myxococcus xanthus cells self-organize into aligned groups, clusters, at various stages of their lifecycle. Formation of these clusters is crucial for the complex dynamic multi-cellular behavior of these bacteria. However, the mechanism…

Biological Physics · Physics 2016-02-17 Rajesh Balagam , Oleg A. Igoshin

Myxococcus xanthus is a model organism for studying bacterial social behaviors due to its ability to form complex multi-cellular structures. Knowledge of M. xanthus surface gliding motility and the mechanisms that coordinate it are…

We study a two-dimensional crystal composed of active units governed by self-alignment. This mechanism induces a torque that aligns a particle's orientation with its velocity and leads to a phase transition from a disordered to a flocking…

Soft Condensed Matter · Physics 2025-06-17 Marco Musacchio , Alexander P. Antonov , Hartmut Löwen , Lorenzo Caprini

From biofilm and colony formation in bacteria to wound healing and embryonic development in multicellular organisms, groups of living cells must often move collectively. While considerable study has probed the biophysical mechanisms of how…

Biological Physics · Physics 2022-06-08 Benedikt Sabass , Howard A. Stone , Joshua W. Shaevitz

Using a multi-phase field model, we examine how particle deformability, which is a proxy for cell stiffness, affects motility induced phase separation (MIPS). We show that purely repulsive deformable, i.e., squishy, cells phase separate…

Soft Condensed Matter · Physics 2025-02-12 Austin Hopkins , Benjamin Loewe , Michael Chiang , Davide Marenduzzo , M. Cristina Marchetti

Phase separation drives the formation of biomolecular condensates in cells, which comprise many components and sometimes possess multiple phases. The equilibrium physics of phase separation is well understood, but many components in…

Soft Condensed Matter · Physics 2025-08-14 Yicheng Qiang , Chengjie Luo , David Zwicker

Nutritional regulation by ants emerges from a distributed process: food is collected by a small fraction of workers, stored within the crops of individuals, and spreads via local ant-to-ant interactions. The precise individual level…

Populations and Evolution · Quantitative Biology 2021-07-26 Efrat Greenwald , Lior Baltiansky , Ofer Feinerman

In this work, a mathematical model of self-oscillatory dynamics of the metabolism in a cell is studied. The full phase-parametric characteristics of variations of the form of attractors depending on the dissipation of a kinetic membrane…

Adaptation and Self-Organizing Systems · Physics 2018-01-17 V. I. Grytsay , I. V. Musatenko

With the help of a mathematical model, the metabolic process of the Krebs cycle is studied. The autocatalytic processes resulting in both the formation of the self-organization in the Krebs cycle and the appearance of a cyclicity of its…

Molecular Networks · Quantitative Biology 2017-10-26 V. I. Grytsay , I. V. Musatenko

Motivated by observations of the dynamics of {\it Myxococcus xanthus}, we present a self-interacting random walk model that describes the competition between chemokinesis and chemotaxis. Cells are constrained to move in one dimension, but…

Statistical Mechanics · Physics 2016-08-31 Maria R. D'Orsogna , Marc Suchard , Tom Chou

We model an enclosed system of bacteria, whose motility-induced phase separation is coupled to slow population dynamics. Without noise, the system shows both static phase separation and a limit cycle, in which a rising global population…

Statistical Mechanics · Physics 2017-11-08 Tobias Grafke , Michael E. Cates , Eric Vanden-Eijnden

Our knowledge of how individual cells self-organize to form complex multicellular systems is being revolutionized by a data outburst, coming from high-throughput experimental breakthroughs such as single-cell RNA sequencing and spatially…

Cell Behavior · Quantitative Biology 2021-04-20 Gabriel Torregrosa , Jordi Garcia-Ojalvo

Proliferation and motility are ubiquitous drivers of activity in biological systems. Here, we study a dense binary mixture of motile and proliferating particles with exclusively repulsive interactions, where homeostasis in the proliferating…

Soft Condensed Matter · Physics 2025-06-11 Lukas Hupe , Joanna M. Materska , David Zwicker , Ramin Golestanian , Bartlomiej Waclaw , Philip Bittihn

Given a $generic$ two-dimensional conformal field theory (CFT), we propose an analytically solvable setup to study the Floquet dynamics of the CFT, i.e., the dynamics of a CFT subject to a periodic driving. A complete phase diagram in the…

Strongly Correlated Electrons · Physics 2018-05-23 Xueda Wen , Jie-Qiang Wu
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