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As for many motile micro-algae, the freshwater species Chlamydomonas reinhardtii can detect light sources and adapt its motile behavior in response. Here, we show that suspensions of photophobic cells can be unstable to density…

Large ensembles of interacting, out-of-equilibrium agents are a paradigm of active matter. Their constituents' intrinsic activity may entail the spontaneous separation into localized phases of high and low densities. Motile microbes,…

The phase transition kinetics in three phase systems was investigated using the numerically efficient cell dynamics method. A phasefield model with a simple analytical free energy and single order parameter was used to study the kinetics…

Materials Science · Physics 2010-03-23 Masao Iwamatsu

The combination of single cells to form doublets is regarded as the rate-limiting step of flocculation and requires the presence of surface proteins in active form. The process of activation of the flocculation proteins of yeast cells is…

Biological Physics · Physics 2007-05-23 Silvia Stan , Florin Despa

Adhesion-independent migration is a prominent mode of cell motility in confined environments, yet the physical principles that guide such movement remain incompletely understood. We present a phase-field model for simulating the motility of…

The sustenance of life depends on the high degree of organization that prevails through different levels of living organisms, from subcellular structures such as biomolecular complexes and organelles to tissues and organs. The physical…

Soft Condensed Matter · Physics 2019-01-14 Hanieh Falahati , Amir Haji-Akbari

The present work continues studies of the mathematical model of a metabolic process of the Krebs cycle. We study the dependence of its cyclicity on the cell respiration intensity determined by the formation level of carbon dioxide. We…

Other Quantitative Biology · Quantitative Biology 2018-04-13 V. I. Grytsay , I. V. Musatenko

Based on symmetry consideration of migration and shape deformations, we formulate phenomenologically the dynamics of cell crawling in two dimensions. Forces are introduced to change the cell shape. The shape deformations induce migration of…

Biological Physics · Physics 2016-03-23 Takao Ohta , Mitsusuke Tarama , Masaki Sano

A phase field approach is proposed to model the chemotaxis of Dictyostelium discoideum. In this framework, motion is controlled by active forces as determined by the Meinhardt model of chemical dynamics which is used to simulate directional…

Biological Physics · Physics 2023-03-01 Yunsong Zhang , Herbert Levine , Yanxiang Zhao

Active soft matter frequently shows motility-induced phase separation (MIPS), where self-propelled particles condensate into clusters with an inner liquid-like structure. Such activity may also result in motility-induced crystallization…

Soft Condensed Matter · Physics 2026-02-24 Max Philipp Holl , Alina Barbar Steinberg , Uwe Thiele

Under hard-agar and nutrient-rich conditions, a cell of $Bacillus$ $subtilis$ grows as a single filament owing to the failure of cell separation after each growth and division cycle. The self-elongating filament of cells shows sequential…

Soft Condensed Matter · Physics 2015-10-16 Ryojiro Honda , Jun-ichi Wakita , Makoto Katori

Self-propelled particles include both self-phoretic synthetic colloids and various micro-organisms. By continually consuming energy, they bypass the laws of equilibrium thermodynamics. These laws enforce the Boltzmann distribution in…

Soft Condensed Matter · Physics 2015-04-15 Michael E. Cates , Julien Tailleur

We develop the hydrodynamic theory of dry, polar ordered, active matter (``flocking") with autochemotaxis; i.e., self-propelled entities moving in the same direction, each emitting a substance which attracts the others (e.g., ants). We find…

Soft Condensed Matter · Physics 2024-01-22 Maxx Miller , John Toner

Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…

Tissues and Organs · Quantitative Biology 2023-03-08 Nen Saito , Shuji Ishihara

A crowd of nonequilibrium entities can show phase transition behaviors that are prohibited in conventional equilibrium setups. An interesting question is whether similar activity-driven phase transitions also occur in pure quantum systems.…

Statistical Mechanics · Physics 2022-06-28 Kyosuke Adachi , Kazuaki Takasan , Kyogo Kawaguchi

Cells control the size and organization of biomolecular condensates formed by liquid-liquid phase separation (LLPS), but multiple mechanisms likely contribute to this control and remain to be fully elucidated. Here we propose a…

Biological Physics · Physics 2026-04-10 Le Qiao , Peter Gispert , Lukas S. Stelzl , Friederike Schmid

Bacterial swarming is a rapid mass-migration, in which thousands of cells spread collectively to colonize a surface. Physically, swarming is a natural example of active particles that use energy to generate motion. Accordingly,…

Soft Condensed Matter · Physics 2019-11-14 Avraham Be`er , Bella Ilkanaiv , Renan Gross , Daniel B. Kearns , Sebastian Heidenreich , Markus Bär , Gil Ariel

We have modeled the metabolic process running in aerobic cells as open nonlinear dissipative systems. The map of metabolic paths and the general scheme of a dissipative system participating in the transformation of steroids are constructed.…

Other Quantitative Biology · Quantitative Biology 2020-06-09 V. I. Grytsay , A. G. Medentsev , A. Yu. Arinbasarova

This work continues the study of the earlier constructed mathematical model of the metabolic process running in a cell. We will consider auto-oscillations arising on the level of enzyme-substrate interactions in the nutrient and respiratory…

Chaotic Dynamics · Physics 2017-07-27 V. I. Grytsay , I. V. Musatenko

We experimentally study a periodically driven many-body localized system realized by interacting fermions in a one-dimensional quasi-disordered optical lattice. By preparing the system in a far-from-equilibrium state and monitoring the…

Quantum Gases · Physics 2017-05-24 Pranjal Bordia , Henrik Lüschen , Ulrich Schneider , Michael Knap , Immanuel Bloch