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Stimulated Raman scattering (SRS) microscopy is a highly sensitive chemical imaging technique. However, the broader application of SRS has been limited by two key challenges: the reliance on low-noise but bulky solid-state laser sources and…

We demonstrate sensitive high-resolution stimulated Raman measurements of hydrogen using a hollow-core photonic crystal fiber (HC-PCF). The Raman transition is pumped by a narrow linewidth (<50 kHz) 1064 nm continuous-wave (CW) fiber laser.…

Optics · Physics 2015-06-16 Philip G. Westergaard , Mikael Lassen , Jan C. Petersen

Label-free microscopy exploits light scattering to obtain a three-dimensional image of biological tissues. However, light propagation is affected by aberrations and multiple scattering, which drastically degrade the image quality and limit…

In the realm of healthcare, label-free sensing is a vital component for various applications. Micro-photonic technology presents a promising avenue to pursue pivotal goals. With the use of this technology, healthcare professionals and…

Optics · Physics 2024-04-24 Giuseppina Simone

Raman spectroscopy is one of the key techniques in the study of vibrational modes and molecular structures. In Coherent Anti-Stokes Raman Scattering (CARS) spectroscopy, a molecular vibrational spectrum is resolved via the third-order…

Optics · Physics 2010-12-02 Ori Katz , Jonathan M. Levitt , Eran Grinvald , Yaron Silberberg

Second Harmonic Generation Microscopy (SHG) is generally acknowledged as a powerful tool for the label-free 3D visualization of tissues and advanced materials, with one of its most popular applications being collagen imaging. Although the…

We study coherent anti-Stokes Raman spectroscopy in air-filled anti-resonance hollow-core photonic crystal fiber, otherwise known as 'revolver' fiber. We compare the vibrational coherent anti-Stokes Raman signal of N$_2$, at 2331 cm$^{-1}$,…

High-quality microresonators can greatly enhance light-matter interactions and are excellent platforms for studying nonlinear optics. Wavelength conversion through nonlinear processes is the key to many applications of integrated optics.…

Optics · Physics 2024-06-27 Yuxuan He , Xiongshuo Yan , Jiangwei Wu , Xiangmin Liu , Yuping Chen , Xianfeng Chen

We investigate lensless endoscopy using coherent beam combining and aperiodic multicore fibers (MCF). We show that diffracted orders, inherent to MCF with periodically arranged cores, dramatically reduce the field of view (FoV) and that…

Soft robotic instruments could navigate delicate, tortuous anatomy more safely than rigid tools, but clinical adoption is limited by insufficient tip functionalization and real-time feedback at the tissue interface. Few sensing and…

Holographic wavefront manipulation enables converting hair-thin multimode optical fibres into minimally invasive lensless imaging instruments conveying much higher information densities than conventional endoscopes. Their most prominent…

The integration of stimulated Raman scattering (SRS) and second order nonlinearity in non-centrosymmetric photonic microresonators presents a highly promising solution for developing on-chip coherent light sources with exceptional bandwidth…

In this letter, we present a high pulse energy Raman laser at 1946 nm wavelength directly pumped with a 1533 nm custom-made fiber laser. The Raman laser is based on the stimulated Raman scattering (SRS) in an 8-meter carbon dioxide (CO2)…

The emergence of label-free microscopy techniques has significantly improved our ability to precisely characterize biochemical targets, enabling non-invasive visualization of cellular organelles and tissue organization. Each label-free…

Optics · Physics 2024-05-08 Lang Wang , Maxine Xii , Ali Pezeshki , Randy Bartels

Optical coherence tomography (OCT) microscope (OCM) uses a high-numerical-aperture objective to achieve cellular-level lateral resolution. However, its practical imaging depth range is limited by the depth of focus (DOF). Although…

Raman spectroscopy reveals chemically specific information and provides label-free insight into the molecular world. However, the signals are intrinsically weak and call for enhancement techniques. Here, we demonstrate Purcell enhancement…

Raman scattering, an inelastic scattering mechanism, provides information about molecular excitation energies and can be used to identify chemical compounds. Albeit being a powerful analysis tool, especially for label-free biomedical…

For several centuries, far-field optical microscopy has remained a key instrument in many scientific disciplines including physical, chemical and biomedical research. Nonetheless, far-field imaging has many limitations: the spatial…

Optics · Physics 2020-01-27 Lyubov V. Amitonova , Johannes F. de Boer

We present an approach for two-dimensional (2D) imaging through a single single-mode or multimode fiber without the need for scanners. A random scattering medium placed next to the distal end of the fiber is used to encode the collected…

Optics · Physics 2014-11-04 Sylwia M. Maliszewska , Ori Katz , Mathias Fink , Sylvain Gigan

Due to their sub picosecond temporal resolution, coherent Raman spectroscopies have been proposed as a viable extension of Spontaneous Raman (SR) thermometry, to determine dynamics of mode specific vibrational energy content during out of…

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