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Confocal and multi-photon microscopy are widely used for in-vivo fluorescence imaging of biological tissues such as the brain, offering non-invasive access up to ~1 mm depth without major loss in performance. A recently-developed…

Quantitative phase microscopy (QPM) is a label-free technique that enables to monitor morphological changes at subcellular level. The performance of the QPM system in terms of spatial sensitivity and resolution depends on the coherence…

The photo-kinetics of fluorescent molecules have enabled the circumvention of far-field optical diffraction-limit. Despite its enormous potential, the necessity to label the sample may adversely influence the delicate biology under…

Optical imaging through scattering media is a fundamental challenge in many applications. Recently, substantial breakthroughs such as imaging through biological tissues and looking around corners have been obtained by the use of…

Optics · Physics 2020-07-09 Tomer Yeminy , Ori Katz

Raman lasers based on bulk diamond are a valuable resource for generating coherent light in wavelength regimes where no common laser diodes are available. Nevertheless, the widespread use of such lasers is limited by their high threshold…

We propose to use high numerical aperture single mode optical fibers like photonic crystal fiber for lensless in-line holographic microscopy. Highly divergent beam helps to overcome the spatial sampling limitation of the image sensor. In…

Optics · Physics 2020-07-01 Sanjeev Kumar , Manjunatha Mahadevappa , Pranab K. Dutta

The paper provides a comprehensive study on Raman spectroscopy versatility as a fast and non destructive tool for the prediction of the mechanical properties of SiC fibers derived from a polymeric precursor (NLM, Hi, Hi-S, SA and Sylramic…

Materials Science · Physics 2016-08-14 Gwénael Gouadec , Philippe Colomban

The HERMES high-resolution spectrograph project aims at exploiting the specific potential of small but flexible telescopes in observational astrophysics. The optimised optical design of the spectrograph is based on the well-proven concept…

A major open challenge in neuroscience is the ability to measure and perturb neural activity in vivo from well-defined neural sub-populations at cellular resolution anywhere in the brain. However, limitations posed by scattering and…

Biological Physics · Physics 2017-11-10 Shay Ohayon , Antonio Miguel Caravaca-Aguirre , Rafael Piestun , James J. DiCarlo

Label-free characterization of biological specimens seeks to supplement existing imaging techniques and avoid the need for contrast agents that can disturb the native state of living samples. Conventional label-free optical imaging…

Magnetic Resonance Imaging (MRI) is the gold standard in countless diagnostic procedures, yet hardware complexity, long scans, and cost preclude rapid screening and point-of-care use. We introduce Imageless Magnetic Resonance Diagnosis…

We propose a novel technique of microscopy to overcome the effects of both scattering and limitation of the accessible depth due to the objective working distance. By combining Laser Optical Feedback Imaging (LOFI) with Acoustic Photon…

We consider quantum interference effects in carrier and photocurrent excitation in graphene using coherent electromagnetic field components at frequencies $\omega$ and $2\omega$. The response of the material at the fundamental frequency…

Mesoscale and Nanoscale Physics · Physics 2014-09-24 J. Rioux , J. E. Sipe , Guido Burkard

Modern materials science requires efficient processing and characterization techniques for low dimensional systems. Raman spectroscopy is an important non-destructive tool, which provides enormous information on these materials. This…

Mesoscale and Nanoscale Physics · Physics 2009-11-10 A. Singha , P. Dhar , Anushree Roy

Artificial nanostructures with ultrafine and deep-subwavelength feature sizes have emerged as a paradigm-shifting platform to advanced light field management, becoming a key building block for high-performance integrated optoelectronics and…

Lensless on-chip microscopy has shown great potential for biomedical imaging due to its large-area and high-throughput imaging capabilities. By combining the pixel super-resolution (PSR) technique, it can improve the resolution beyond the…

Image and Video Processing · Electrical Eng. & Systems 2024-09-06 Xuyang Chang , Shaowei Jiang , Yongcun Hu , Liheng Bian

Quantitative phase microscopy (QPM) enables label-free measurement of local optical path length variations, providing critical insight into the structure and dynamics of transparent biological specimens. Here, a highly sensitive lateral…

We describe a new pushbroom hyperspectral imaging device that has no macro moving part. The main components of the proposed hyperspectral imager are a digital micromirror device (DMD), a CMOS image sensor with no filter as the spectral…

Computer Vision and Pattern Recognition · Computer Science 2019-05-22 Reza Arablouei , Ethan Goan , Stephen Gensemer , Branislav Kusy

The vibrational and electronic properties of 2-dimensinal (2D) materials can be efficiently tuned by external strain due to their good stretchability. Resonant Raman spectroscopy is a versatile tool to study the physics of phonons,…

Mesoscale and Nanoscale Physics · Physics 2019-06-05 Chaoyu Song , Fengren Fan , Ningning Xuan , Shenyang Huang , Chong Wang , Guowei Zhang , Fanjie Wang , Qiaoxia Xing , Yuchen Lei , Zhengzong Sun , Hua Wu , Hugen Yan

Many essential cellular functions depend on the viscoelastic properties of the cytoplasm. While techniques such as optical tweezers and atomic force microscopy can measure these properties, their reliance on localized probes prevents…

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