Related papers: Continuum gating current models computed with cons…
The physical mechanism underlying the voltage-dependent gating of K channels is usually addressed theoretically using molecular dynamics simulations.However, besides being computationally very expensive, this approach is presently unable to…
Experiments on single ionic channels have contributed to a large extent to our current view on the function of cell membrane. In these experiments the main observables are the physical quantities: ionic concentration, membrane electrostatic…
We develop a method for calculation of charge transfer statistics of persistent current in nanostructures in terms of the cumulant generating function (CGF) of transferred charge. We consider a simply connected one-dimensional system (a…
Synthetic lipid membranes can display channel-like ion conduction events even in the absence of proteins. We show here that these events are voltage-gated with a quadratic voltage dependence as expected from electrostatic theory of…
Electrical signaling via voltage-gated ion channels depends upon the function of the voltage sensor (VS), identified with the S1-S4 domain of voltage-gated K channels. Here we investigate some physical aspects of the sliding-helix model of…
Electrical signaling via voltage-gated ion channels depends upon the function of a voltage sensor (VS), identified with the S1-S4 domain in voltage-gated K+ channels. Here we investigate some energetic aspects of the sliding-helix model of…
Voltage gated channel proteins cooperate in the transmission of membrane potentials between nerve cells. With the recent progress in atomic-scaled biological chemistry it has now become established that these channel proteins provide highly…
The effect of electronic current on the atomic motion still poses many open questions, and several mechanisms are at play. Recently there has been focus on the importance of the current-induced non-conservative forces (NC) and Berry-phase…
Experiments measuring currents through single protein channels show unstable currents. Channels switch between 'open' or 'closed' states in a spontaneous stochastic process called gating. Currents are either (nearly) zero or at a definite…
Emulate the gating mechanism of ionic channels in neurons, we present a mathematical model for the time constant of dynamical systems. Our model is an analytical continues function. The analyses give evidence that one can adjust the…
We consider an exactly tractable model of the Kramers type for the voltage-dependent gating dynamics of single ion channels. It is assumed that the gating dynamics is caused by the thermally activated transitions in a bistable potential.…
Experiments measuring currents through single protein channels show unstable currents, a phenomena called the gating of a single channel. Channels switch between an 'open' state with a well defined single amplitude of current and 'closed'…
Quantum calculations on the voltage sensing domain (VSD) of the Kv1.2 potassium channel (pdb: 3Lut)have been carried out on a 904 atoms subset of the VSD, plus 24 water molecules. Side chains pointing away from the center of the VSD were…
A new scattering approach for correlated one-dimensional systems is developed. The adiabatic contact to charge reservoirs is encoded in time-dependent boundary conditions. The conductance matrix for an arbitrary gated wire, respecting…
The persistent current in small isolated rings enclosing magnetic flux is the current circulating in equilibrium in the absence of an external excitation. While initially studied in superconducting and normal metals, recently, atomic…
The physiology of voltage gated ion channels is complex and insights into their gating mechanism is incomplete. Their function is best represented by Markov models with relatively large number of distinct states that are connected by…
The non-selective voltage activated cation channel from the human red cells, which is activated at depolarizing potentials, has been shown to exhibit counter-clockwise gating hysteresis. We have analyzed the phenomenon with the simplest…
Chiral active matter, which breaks both parity symmetry and time-reversal symmetry, is ubiquitous in living systems. Here, we introduce a minimal two-dimensional chiral active lattice gas by incorporating stochastic, biased local rotations.…
In nonequilibrium systems with uncoupled currents, the thermodynamic affinity determines the direction of currents, quantifies dissipation, and constrains current fluctuations. However, these properties of the thermodynamic affinity do not…
Graphene flow sensors hold great prospects for applications, but also encounter many difficulties, such as unwanted electrochemical phenomena, low measurable signal and limited dependence on the flow direction. This study proposes a novel…