Related papers: Results from a Prototype Proton-CT Head Scanner
Positron emission tomography (PET) is a critical tool for diagnosing tumors and neurological disorders but poses radiation risks to patients, particularly to sensitive populations. While reducing injected radiation dose mitigates this risk,…
Delineation of tumors and organs-at-risk permits detecting and correcting changes in the patients' anatomy throughout the treatment, making it a core step of adaptive proton therapy (APT). Although AI-based auto-contouring technologies have…
Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…
Computed Tomography (CT) imaging is one of the most influential diagnostic methods. In clinical reconstruction, an effective energy is used instead of total X-ray spectrum. This approximation causes an accuracy decline. To increase the…
Liquid xenon time projection chambers offer a homogeneous detection medium with excellent intrinsic energy resolution, fast scintillation, and true three-dimensional position sensitivity, making them an attractive alternative to…
The growing interest in human-grade total body positron emission tomography (PET) systems has also application in small animal research. Due to the existing limitations in human-based studies involving drug development and novel treatment…
Dosimetry in BNCT poses significant challenges due to the indirect effect of neutrons interacting with elements within the body and uncertainties associated with the uptake of boron compounds used in clinical practice. Current treatment…
Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…
Ultra low radiation dose in X-ray Computed Tomography (CT) is an important clinical objective in order to minimize the risk of carcinogenesis. Compressed Sensing (CS) enables significant reductions in radiation dose to be achieved by…
Two major challenges in time-of-flight positron emission tomography (TOF-PET) are low spatial resolution and high radioactive dose to the patient, both of which result from limitations in detection technology rather than fundamental…
Photon-Counting Computed Tomography (PCCT) is a novel imaging modality that simultaneously acquires volumetric data at multiple X-ray energy levels, generating separate volumes that capture energy-dependent attenuation properties.…
PET is a functional imaging technique based on detection of annihilation photons following beta decay producing positrons. In this paper, we present the concept of a new PET system for preclinical applications consisting of a ring of twelve…
Accurate proton dose calculation using Monte Carlo (MC) is computationally demanding in workflows like robust optimisation, adaptive replanning, and probabilistic inference, which require repeated evaluations. To address this, we develop a…
Objective: Accurate estimation of SAR is critical to safeguarding vulnerable patients who require an MRI procedure. The increased static field strength and RF duty cycle capabilities in modern MRI scanners mean that systems can easily…
Computed tomography (CT) involves a patient's exposure to ionizing radiation. To reduce the radiation dose, we can either lower the X-ray photon count or down-sample projection views. However, either of the ways often compromises image…
Background: Whereas filtered back projection algorithms for voxel-based CT image reconstruction have noise properties defined by the filter, iterative algorithms must stop at some point in their convergence and do not necessarily produce…
Recent advances in photon detectors have resulted in high-density imaging arrays that offer many performance and cost advantages. In particular, the excellent transit time spread of certain devices show promise to provide tangible benefits…
Proton scattering in some water and tissue equivalent phantom materials was measured to evaluate their simulation accuracy of water and respective human biological tissues. The measurements were performed on the medical facility of the ITEP…
This is a review paper on some of the physics, modeling, and iterative algorithms in proton computed tomography (pCT) image reconstruction. The primary challenge in pCT image reconstruction lies in the degraded spatial resolution resulting…
Objective: To assess the accuracy and computational performance of a stochastic differential equation (SDE)--based model for proton beam dose calculation by benchmarking against Geant4 in simplified phantom geometries. Approach: Building on…