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In complex clinical trials, multiple research objectives are often grouped into sets of objectives based on their inherent hierarchical relationships. Consequently, the hypotheses formulated to address these objectives are grouped into…

Methodology · Statistics 2016-11-11 Zhiying Qiu , Wenge Guo , Sanat Sarkar

This paper presents a survey on some recent advances for the type I error rate control in multiple testing methodology. We consider the problem of controlling the $k$-family-wise error rate (kFWER, probability to make $k$ false discoveries…

Methodology · Statistics 2011-03-15 Etienne Roquain

Adjustment of statistical significance levels for repeated analysis in group sequential trials has been understood for some time. Similarly, methods for adjustment accounting for testing multiple hypotheses are common. There is limited…

Methodology · Statistics 2023-11-28 Yujie Zhao , Qi Liu , Linda Z. Sun , Keaven M. Anderson

Statistical learning theory and the Probably Approximately Correct (PAC) criterion are the common approach to mathematical learning theory. PAC is widely used to analyze learning problems and algorithms, and have been studied thoroughly.…

Machine Learning · Computer Science 2024-05-03 Adi Hendel , Meir Feder

Primarily motivated by the drug development process, several publications have now presented methodology for the design of multi-arm multi-stage experiments with normally distributed outcome variables of known variance. Here, we extend…

Methodology · Statistics 2017-12-04 Michael Grayling , James Wason , Adrian Mander

Deep Learning methods are renowned for their performances, yet their lack of interpretability prevents them from high-stakes contexts. Recent model agnostic methods address this problem by providing post-hoc interpretability methods by…

Machine Learning · Computer Science 2021-11-30 Marco Repetto

Simultaneous inference allows for the exploration of data while deciding on criteria for proclaiming discoveries. It was recently proved that all admissible post-hoc inference methods for true discoveries must employ closed testing. In this…

Statistics Theory · Mathematics 2022-03-24 Jinjin Tian , Xu Chen , Eugene Katsevich , Jelle Goeman , Aaditya Ramdas

A reliable deep learning system should be able to accurately express its confidence with respect to its predictions, a quality known as calibration. One of the most effective ways to produce reliable confidence estimates with a pre-trained…

Machine Learning · Computer Science 2024-10-10 Thomas P. Zollo , Zhun Deng , Jake C. Snell , Toniann Pitassi , Richard Zemel

Open-set recognition systems face a neglected failure mode: high-confidence near-known unknowns, which lie outside the known label set but are close enough to known classes that a closed-set classifier accepts them with high confidence. We…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Xi Chen , Yingjun Xiao , Gang Fang

It is quite common in modern research, for a researcher to test many hypotheses. The statistical (frequentist) hypothesis testing framework, does not scale with the number of hypotheses in the sense that naively performing many hypothesis…

Methodology · Statistics 2013-06-26 Jonathan Rosenblatt

The $\gamma$-FDP and $k$-FWER multiple testing error metrics, which are tail probabilities of the respective error statistics, have become popular recently as less-stringent alternatives to the FDR and FWER. We propose general and flexible…

Methodology · Statistics 2016-12-20 Jay Bartroff

In a multiple testing problem where one is willing to tolerate a few false rejections, procedure controlling the familywise error rate (FWER) can potentially be improved in terms of its ability to detect false null hypotheses by…

Statistics Theory · Mathematics 2008-12-18 Sanat K. Sarkar

A statistical test can be seen as a procedure to produce a decision based on observed data, where some decisions consist of rejecting a hypothesis (yielding a significant result) and some do not, and where one controls the probability to…

Statistics Theory · Mathematics 2017-10-19 Aaron McDaid , Zoltan Kutalik , Valentin Rousson

To perform inference after model selection, we propose controlling the selective type I error; i.e., the error rate of a test given that it was performed. By doing so, we recover long-run frequency properties among selected hypotheses…

Statistics Theory · Mathematics 2017-04-19 William Fithian , Dennis Sun , Jonathan Taylor

This research deals with massive multiple hypothesis testing. First regarding multiple tests as an estimation problem under a proper population model, an error measurement called Erroneous Rejection Ratio (ERR) is introduced and related to…

Statistics Theory · Mathematics 2007-06-13 Cheng Cheng

For a high-dimensional linear model with a finite number of covariates measured with error, we study statistical inference on the parameters associated with the error-prone covariates, and propose a new corrected decorrelated score test and…

Methodology · Statistics 2020-01-29 Mengyan Li , Runze Li , Yanyuan Ma

Improved procedures, in terms of smaller missed discovery rates (MDR), for performing multiple hypotheses testing with weak and strong control of the family-wise error rate (FWER) or the false discovery rate (FDR) are developed and studied.…

Statistics Theory · Mathematics 2011-03-10 Edsel A. Peña , Joshua D. Habiger , Wensong Wu

Clustering is part of unsupervised analysis methods that consist in grouping samples into homogeneous and separate subgroups of observations also called clusters. To interpret the clusters, statistical hypothesis testing is often used to…

Methodology · Statistics 2022-10-25 Benjamin Hivert , Denis Agniel , Rodolphe Thiébaut , Boris P Hejblum

Hierarchical inference in (generalized) regression problems is powerful for finding significant groups or even single covariates, especially in high-dimensional settings where identifiability of the entire regression parameter vector may be…

Methodology · Statistics 2021-10-22 Claude Renaux , Peter Bühlmann

Word error rate (WER) as a metric has a variety of limitations that have plagued the field of speech recognition. Evaluation datasets suffer from varying style, formality, and inherent ambiguity of the transcription task. In this work, we…