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We demonstrate 'differential dynamic microscopy' (DDM) for the fast, high throughput characterization of the dynamics of active particles. Specifically, we characterize the swimming speed distribution and the fraction of motile cells in…

Quantitative Methods · Quantitative Biology 2011-07-12 Laurence G. Wilson , Vincent A. Martinez , Jana Schwarz-Linek , J. Tailleur , Peter N. Pusey , Gary Bryant , Wilson C. K. Poon

The stoichiometry of metabolic networks usually gives rise to a family of conservation laws for the aggregate concentration of specific pools of metabolites, which not only constrain the dynamics of the network, but also provide key insight…

Molecular Networks · Quantitative Biology 2013-09-11 A. De Martino , D. De Martino , R. Mulet , A. Pagnani

Cell-free protein synthesis (CFPS) systems are an attractive to complement the usual cell-based synthesis of proteins, especially for screening approaches. The literature describes a wide variety of CFPS systems, but their performance is…

Biomolecules · Quantitative Biology 2023-03-14 Jascha Rolf , Julian Handke , Frank Burzinski , Stephan Luetz , Katrin Rosenthal

Bacteria sense a diverse range of environmental analytes with high sensitivity and temporal resolution. Engineering and synthetic biology approaches enabled harnessing this capability through development of whole-cell biosensors that…

Analysis of flow cytometry data is an essential tool for clinical diagnosis of hematological and immunological conditions. Current clinical workflows rely on a manual process called gating to classify cells into their canonical types. This…

Machine Learning · Statistics 2017-11-29 Disi Ji , Eric Nalisnick , Padhraic Smyth

The swimming properties of an E. coli-type model bacterium are investigated by mesoscale hy- drodynamic simulations, combining molecular dynamics simulations of the bacterium with the multiparticle particle collision dynamics method for the…

Soft Condensed Matter · Physics 2016-08-23 Jinglei Hu , Mingcheng Yang , Gerhard Gompper , Roland G. Winkler

Microswimmers such as E. Coli bacteria accumulate and exhibit an intriguing dynamics near walls, governed by hydrodynamic and steric interactions. Insight into the underlying mechanisms and predominant interactions demand a detailed…

Soft Condensed Matter · Physics 2020-07-03 S. Mahdiyeh Mousavi , Gerhard Gompper , Roland G. Winkler

An accurate method for enumerating pathogen indicators, such as Escherichia coli (E. coli), and Salmonella spp. is important for assessing the safety of compost samples. This study aimed to determine the occurrence of pathogen indicators in…

Quantitative Methods · Quantitative Biology 2014-04-15 N. M. Sunar , D. I. Stewart , E. I. Stentiford , L. A. Flecther

We provide a Galton--Watson model for the growth of a bacterial population in the presence of antibiotics. We assume that bacterial cells either die or duplicate, and the corresponding probabilities depend on the concentration of the…

Applications · Statistics 2021-04-26 Anita Bogdanov , Péter Kevei , Máté Szalai , Dezső Virok

In microbial studies, samples are often treated under different experimental conditions and then tested for microbial survival. A technique, dating back to the 1880's, consists of diluting the samples several times and incubating each…

Applications · Statistics 2020-03-23 J Andrés Christen , Al Parker

The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as ``anomalous diffusion''. Fluorescence Correlation Spectroscopy (FCS) is a powerful method to…

Quantitative Methods · Quantitative Biology 2024-07-18 Nathan Quiblier , Jan-Michael Rye , Pierre Leclerc , Henri Truong , Abdelkrim Hannou , Laurent Héliot , Hugues Berry

We use moving light patterns to control the motion of {\it Escherichia coli} bacteria whose motility is photo-activated. Varying the pattern speed controls the magnitude and direction of the bacterial flux, and therefore the accumulation of…

Raman spectroscopy is a promising tool for microbial identification, yet its implementation in microbiology and clinical workflow is still restricted due to the accompanying additional preparation required to focus on microbial signals.…

Quantitative Methods · Quantitative Biology 2026-03-19 Jeong Hee Kim , Jia Dong , Marissa Morales , Loza Tadesse

Flow cytometry is a cornerstone technique in medical and biological research, providing crucial information about cell size and granularity through forward scatter (FSC) and side scatter (SSC) signals. Despite its widespread use, the…

Optics · Physics 2024-08-29 Jaepil Jo , Herve Hugonnet , Mahn Jae Lee , YongKeun Park

Clot formation is a common complication in extracorporeal circuits. In this paper we describe a novel method for clot formation analysis using image processing. We assembled a closed extracorporeal circuit and circulated blood at varying…

Computer Vision and Pattern Recognition · Computer Science 2013-04-02 Omid David , Rabin Gerrah

Electrochemical CO2 reduction offers a method to use renewable electricity to convert CO2 into CO and other carbon-based chemical building blocks. While nearly all studies rely on a CO2 feed, we show herein that aqueous bicarbonate…

Cells swimming in confined environments are attracted by surfaces. We measure the steady-state distribution of smooth-swimming bacteria (Escherichia coli) between two glass plates. In agreement with earlier studies, we find a strong…

Soft Condensed Matter · Physics 2008-10-02 Allison P. Berke , Linda Turner , Howard C. Berg , Eric Lauga

The dynamics of growth of bacterial populations has been extensively studied for planktonic cells in well-agitated liquid culture, in which all cells have equal access to nutrients. In the real world, bacteria are more likely to live in…

Populations and Evolution · Quantitative Biology 2017-11-01 Xinxian Shao , Andrew Mugler , Justin Kim , Ha Jun Jeong , Bruce Levin , Ilya Nemenman

Centrifugation is a widespread laboratory technique used to separate mixtures into fractions characterized by a specific size, weight or density. We demonstrate that centrifugation can be also used to separate swimming cells having…

Soft Condensed Matter · Physics 2014-11-07 Claudio Maggi , Alessia Lepore , Jacopo Solari , Alessandro Rizzo , Roberto Di Leonardo

Integrating optical diffraction tomography with imaging flow cytometry enables label-free quantifications of the three-dimensional (3D) morphology and hemoglobin content of red blood cells (RBCs) in their natural form. Self-rotation of RBCs…

Medical Physics · Physics 2023-09-28 Yu-Hsiang Chang , Yang-Hsien Lin , Kung-Bin Sung
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